Results 221 to 230 of about 1,590,241 (290)

Mechanistic insights into hydroxynaphthoic acid-based suppression of lignin repolymerization.

RSC Sustain
Li C, Eckl MAU, Fitz P, Pielhop T, Vernuccio S.   +4 more
europepmc   +1 more source

CYP82G1 Enzyme Functions as Chromone Hydroxylase in the Biosynthesis of 6-Hydroxy-2-(2-Phenylethyl)chromone in Aquilaria sinensis. [PDF]

Plant Biotechnol J
Wu W, Yan T, Zhao Y, Zhang X, Wilson I, Li G, Wang H, Mei W, Wu R, Sun X, Jiang L, Jiang X, Shao F, Qiu D.   +13 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Urinary volatilomics using liquid-liquid extraction and gas chromatography-mass spectrometry (GC-MS) combined with machine learning algorithms as a tool for diagnosis and surveillance of urothelial bladder cancer. [PDF]

BJC Rep
Deza I, de Lacy Costello B, Drabińska-Fois N, White P, Ratcliffe N, Lazarowicz H, Probert C.   +6 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Performance of a modular robotic cluster matches skilled human operators for complex cell therapy manufacturing tasks. [PDF]

Int J Pharm X
Sadhu S, Schmittlein B, Lares A, Cheng C, Chen X, Bhatia V, Zha W, Wah S, Nayak S, Uboldi M, Yu Y, Wang J, Zhang W, Bhanap PP, Ji Y, Scheffler A, Wilson J, Welch D, Gkitsas-Long N, Retherford AJ, Tunuguntla R, Melocchi A, Girard A, Parietti F, Feldman SA, Esensten JH.   +25 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Applications of Optical Fiber Sensors in Geotechnical Engineering: Laboratory Studies and Field Implementation at the Acropolis of Athens. [PDF]

Sensors (Basel)
Kapogianni E, Sakellariou M.
europepmc   +1 more source

Hendra and Nipah viruses: Biosafety evidence for risk-based containment, inactivation practices, and one health preparedness. [PDF]

One Health
Blacksell SD, Le KK, Selleck PW, Young JR, Kolenchery JB, Paulley JT, Marsh GA, Ward MP, Gleeson LJ.   +8 more
europepmc   +1 more source