Results 21 to 30 of about 273,730 (211)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Avaliação do risco de incêndio em centros urbanos antigos parte I – aplicação do método de ARICA ao centro histórico do Funchal

Territorium: Revista Portuguesa de riscos, prevenção e segurança, 2011
A diferente concepção e materiais usados nas construções antigas fazem com que estas apresentem um risco de incêndio agravado. Tendo como objectivo avaliar o risco de incêndio do centro histórico do Funchal aplicaram-se os métodos de Gretener e ARICA a ...
Rui Figueira, João Paulo C. Rodrigues, António Leça Coelho   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Organización espacial en el Piedemonte Amazónico colombiano: Elemento clave para la cohesión nacional y el desarrollo regional

Cuadernos de Geografía: Revista Colombiana de Geografía, 2003
En este documento se describe y analiza la orgaruzación espacial del piedemonte amazóruco. El documento hace énfasis en cómo esa organización es producto de unas relaciones de dependencia enlre la región y el interior del país, pero también se plantea la
Luis Carlos Jimenez Reyes, Jhon Williams Montoya Garay   +1 more
doaj   +2 more sources

De lo con-céntrico a lo des-centrado. Reflexiones sobre el lugar y el no-lugar en la arquitectura. / From the concentric to the off-center. Reflections on the place and the non-place in architecture.

Revista de Urbanismo, 2012
Se propone, a través de la figura del círculo, abrir una reflexión sobre sus propiedades, su presencia y permanencia lo largo de la historia así como en nuestros días.
Laura Gallardo Frías
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

¿Por qué la gente no usa el Metro? Efectos del transporte en la Zona Metropolitana de la Ciudad de México

Investigaciones Geográficas, 2017
Ese artículo aborda por qué el Metro de la Ciudad de México se usa menos que otros medios de transporte, según datos del 2007 y tambien de 2015. Explicamos esta baja movilidad por factores como la distancia de caminata a las estaciones, la cobertura del ...
Masanori Murata, Javier Delgado Campos, Manuel Suárez Lastra   +2 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

No centro da periferia, a periferia no centro [PDF]

, 2015
Este trabalho se propõe a refl etir sobre a cronotopia, considerando a sua infl uência nas formas de expressão cultural provenientes de espaços urbanos segregados no Brasil. Trata, especifi camente, do funk carioca como expressão cultural integrante do movimento hip hop no Rio de Janeiro.
Paula, Luciane de, Paula, Sandra Leila de   +1 more
openaire  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source