Results 21 to 30 of about 487,039 (263)

Avaliação do risco de incêndio em centros urbanos antigos parte I – aplicação do método de ARICA ao centro histórico do Funchal

Territorium: Revista Portuguesa de riscos, prevenção e segurança, 2011
A diferente concepção e materiais usados nas construções antigas fazem com que estas apresentem um risco de incêndio agravado. Tendo como objectivo avaliar o risco de incêndio do centro histórico do Funchal aplicaram-se os métodos de Gretener e ARICA a ...
Rui Figueira, João Paulo C. Rodrigues, António Leça Coelho   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

De lo con-céntrico a lo des-centrado. Reflexiones sobre el lugar y el no-lugar en la arquitectura. / From the concentric to the off-center. Reflections on the place and the non-place in architecture.

Revista de Urbanismo, 2012
Se propone, a través de la figura del círculo, abrir una reflexión sobre sus propiedades, su presencia y permanencia lo largo de la historia así como en nuestros días.
Laura Gallardo Frías
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Organización espacial en el Piedemonte Amazónico colombiano: Elemento clave para la cohesión nacional y el desarrollo regional

Cuadernos de Geografía: Revista Colombiana de Geografía, 2003
En este documento se describe y analiza la orgaruzación espacial del piedemonte amazóruco. El documento hace énfasis en cómo esa organización es producto de unas relaciones de dependencia enlre la región y el interior del país, pero también se plantea la
Luis Carlos Jimenez Reyes, Jhon Williams Montoya Garay   +1 more
doaj   +2 more sources

¿Por qué la gente no usa el Metro? Efectos del transporte en la Zona Metropolitana de la Ciudad de México

Investigaciones Geográficas, 2017
Ese artículo aborda por qué el Metro de la Ciudad de México se usa menos que otros medios de transporte, según datos del 2007 y tambien de 2015. Explicamos esta baja movilidad por factores como la distancia de caminata a las estaciones, la cobertura del ...
Masanori Murata, Javier Delgado Campos, Manuel Suárez Lastra   +2 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

No centro da periferia, a periferia no centro [PDF]

, 2015
Este trabalho se propõe a refl etir sobre a cronotopia, considerando a sua infl uência nas formas de expressão cultural provenientes de espaços urbanos segregados no Brasil. Trata, especifi camente, do funk carioca como expressão cultural integrante do movimento hip hop no Rio de Janeiro.
Paula, Luciane de, Paula, Sandra Leila de   +1 more
openaire  

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source