Results 21 to 30 of about 177,089 (78)

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy

Cells, 2020
The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter- and intra-cellular communication, which regulates fundamental cell functions such as growth, survival, and differentiation.
Ufuk Degirmenci, Mei Wang, Jiancheng Hu
semanticscholar   +1 more source

SPSTL SB RAS Collection of Scantily Used Editions in the Readers Service System

Proceedings of SPSTL SB RAS, 2023
Developing programs of new directions of work with readers in the changing sociocultural conditions is an actual orientation of domestic librarianship policy.
G. Vikhreva, N. V. Makhotina, O. Fedotova   +2 more
semanticscholar   +1 more source

The Average “Portrait” of SPSTL SB RAS Contemporary Reader

Proceedings of SPSTL SB RAS, 2023
The purpose of the article is to actualize the idea readers’ satisfaction with organization of work and quality of library and information services provided by the largest beyond the Urals information institution – State Public Scientific-Technological ...
G. Vikhreva, M. A. Shevchenko
semanticscholar   +1 more source

Farmer Field Schools for Improving Farming Practices and Farmer Outcomes: A Systematic Review

Campbell Systematic Reviews, Volume 10, Issue 1, Page i-335, 2014., 2014
This Campbell systematic review examines the effectiveness of farmer field schools in improving intermediate outcomes (such as knowledge and pesticide use) and final outcomes (such as agricultural yields, incomes and empowerment) in low‐ and middle‐income countries (LMICs), as well as implementation factors associated with programme success and failure.
Hugh Waddington, Birte Snilstveit, Jorge Hombrados, Martina Vojtkova, Daniel Phillips, Philip Davies, Howard White   +6 more
wiley   +1 more source

Prognostic and Predictive Relevance of Primary Tumor Location in Patients With RAS Wild-Type Metastatic Colorectal Cancer Retrospective Analyses of the CRYSTAL and FIRE-3 Trials

JAMA Oncology, 2017
Importance Metastatic colorectal cancer (mCRC) is heterogeneous, and primary tumors arising from different regions of the colon are clinically and molecularly distinct. Objective To examine the prognostic and predictive value of primary tumor location in
S. Tejpar, S. Stintzing, F. Ciardiello, J. Tabernero, E. Cutsem, F. Beier, R. Esser, H. Lenz, V. Heinemann   +8 more
semanticscholar   +1 more source

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

Nature
RAS oncogenes (collectively NRAS, HRAS and especially KRAS) are among the most frequently mutated genes in cancer, with common driver mutations occurring at codons 12, 13 and 611.
M. Holderfield, Bianca J Lee, Jingjing Jiang, A. Tomlinson, Kyle J Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Y. Gindin, Nuntana Dinglasan, Yingyun Wang, L. Lai, Shurui Cai, Lingyan Jiang, N. Nasholm, N. Shifrin, Cristina Blaj, Harshit Shah, James W Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, E. Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, J. Cregg, Yang Liu, Anthony N Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, J. Knox, Jennifer E. Klomp, Jennifer A Roth, M. Rees, Melissa A. Ronan, Antonio Cuevas-Navarro, Feng Hu, P. Lito, David Santamaría, A. Aguirre, Andrew M. Waters, C. Der, Chiara Ambrogio, Zhengping Wang, Adrian L Gill, E. Koltun, J. Smith, D. Wildes, Mallika Singh   +52 more
semanticscholar   +1 more source

Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers

Cancer Discovery
Broad-spectrum inhibition of RAS-GTP with RMC-6236 is active and tolerated at exposures that induce profound tumor regressions in preclinical models of RAS-driven cancers and that can be associated with objective responses in patients with such cancers.
Jingjing Jiang, Lingyan Jiang, B. Maldonato, Yingyun Wang, M. Holderfield, Ida Aronchik, Ian P. Winters, Z. Salman, Cristina Blaj, Marie Ménard, Jens Brodbeck, Zhe Chen, Xing Wei, Michael J Rosen, Y. Gindin, Bianca J Lee, James W Evans, Stephanie Chang, Zhican Wang, Kyle J Seamon, Dylan Parsons, J. Cregg, Abby Marquez, A. Tomlinson, Jason K. Yano, J. Knox, E. Quintana, A. Aguirre, K. Arbour, Abby Reed, W. C. Gustafson, Adrian L Gill, E. Koltun, D. Wildes, J. Smith, Zhengping Wang, Mallika Singh   +36 more
semanticscholar   +1 more source

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Mutants of RAS are major oncogenes and occur in many human cancers, but efforts to develop drugs that directly inhibit the corresponding constitutively active RAS proteins have failed so far.
R. Hillig, B. Sautier, J. Schroeder, D. Moosmayer, A. Hilpmann, C. Stegmann, Nicolas D. Werbeck, H. Briem, U. Boemer, J. Weiske, V. Badock, J. Mastouri, K. Petersen, G. Siemeister, J. Kahmann, D. Wegener, N. Böhnke, K. Eis, Keith Graham, L. Wortmann, F. von Nussbaum, B. Bader   +21 more
semanticscholar   +1 more source

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

Nature Communications, 2020
The first step of RAF activation involves binding to active RAS, resulting in the recruitment of RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction, we present crystal structures of wild-type and oncogenic mutants of ...
T. Tran, A. Chan, L. C. Young, Lakshman K Bindu, Chris Neale, S. Messing, S. Dharmaiah, Troy Taylor, J. Denson, Dominic Esposito, D. Nissley, A. Stephen, F. McCormick, D. Simanshu   +13 more
semanticscholar   +1 more source

A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS

Science, 2019
Organized for action It is becoming increasingly clear that biomolecular condensates, which are concentrations of macromolecules not surrounded by a membrane, are a key organizational structure in eukaryotic cells (see the Perspective by Martin and ...
William Y. C. Huang, Steven Alvarez, Y. Kondo, Young Kwang Lee, J. Chung, Hiu Yue Monatrice Lam, K. Biswas, J. Kuriyan, J. Groves   +8 more
semanticscholar   +1 more source