Results 51 to 60 of about 177,089 (78)

RAS Proteins and Their Regulators in Human Disease

Cell, 2017
Dhirendra K Simanshu, Dwight V Nissley, Frank Mccormick   +2 more
exaly   +2 more sources

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Using geoservices in researching the state of forest ecosystems

Geodesy and Cartography, 2022
The authors propose a means for interdisciplinary cooperation through using geoservices for swapping spatial data. Environmental studies of forest ecosystems often produce results in the form of the mentioned data.
A. Plotnikova, A. O. Kharitonova, D. Ershov, E. Sochilova   +3 more
semanticscholar   +1 more source

ISDM-Rosleskhoz operation and evolution experience

, 2021
The paper marks the 15-th anniversary of the Wildfires Monitoring Information System of the Federal Forestry Agency (ISDM-Rosleskhoz). Creation and development of the system was partaken by many organizations, including the Aerial Forest Protection ...
I. Balashov, E. Loupian, S. Bartalev, M. A. Burtsev, A. Mazurov   +4 more
semanticscholar   +1 more source

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

Cell, 2017
SUMMARY The genetic dependencies of human cancers widely vary. Here, we catalog this heterogeneity and use it to identify functional gene interactions and genotype-dependent liabilities in cancer.
Tim Wang, Bingxu Liu, Arek Kendirli
exaly   +2 more sources

Recirculating aquaculture systems (RAS): Environmental solution and climate change adaptation

, 2021
Considering environmental sustainability and vulnerability to the effects of climate change on fish production, one of the potential adaptation strategies is “Recirculating Aquaculture Systems (RAS)”.
Nesar Ahmed, G. Turchini
semanticscholar   +1 more source

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

Immunity, 2017
Summary The immunosuppressive protein PD‐L1 is upregulated in many cancers and contributes to evasion of the host immune system. The relative importance of the tumor microenvironment and cancer cell‐intrinsic signaling in the regulation of PD‐L1 ...
Matthew A Coelho, Miriam Molina-Arcas, Bradley Spencer-Dene   +2 more
exaly   +2 more sources

Drugging the undruggable RAS: Mission Possible?

Nature Reviews Drug Discovery, 2014
Despite more than three decades of intensive effort, no effective pharmacological inhibitors of the RAS oncoproteins have reached the clinic, prompting the widely held perception that RAS proteins are 'undruggable'.
Adrienne D Cox, Stephen W Fesik, Alec C Kimmelman   +2 more
exaly   +2 more sources

RAS-mediated oncogenic signaling pathways in human malignancies.

Seminars in Cancer Biology, 2019
Abnormally activated RAS proteins are the main oncogenic driver that governs the functioning of major signaling pathways involved in the initiation and development of human malignancies.
A. Q. Khan, S. Kuttikrishnan, K. Siveen, K. Prabhu, Muralitharan Shanmugakonar, H. Al-Naemi, Mohammad Haris, S. Dermime, S. Uddin   +8 more
semanticscholar   +1 more source

Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

Cell, 2021
Juan Guan, Jayanta Debnath, Siyu Feng
exaly  

Targeting RAS signalling pathways in cancer therapy

Nature Reviews. Cancer, 2003
J. Downward
semanticscholar   +1 more source