Results 1 to 10 of about 40,632 (234)

Scaling up production of cephalosporin C by Acremonium chrysogenum W42-I in a fermenter using submerged fermentation [PDF]

AMB Express
Cephalosporins presently stand as the most extensively utilized antibiotic in clinical settings. Acremonium (A.) chrysogenum is the main strain used in the manufacturing of cephalosporin C (CPC), which offers distinct advantages, including a wide-ranging
Asmaa A. Ibrahim, Ghadir S. El-Housseiny, Khaled M. Aboshanab, Ansgar Stratmann, Mahmoud A. Yassien, Nadia A. Hassouna   +5 more
doaj   +3 more sources

Multipoint TvDAAO Mutants for Cephalosporin C Bioconversion. [PDF]

Int J Mol Sci, 2019
d-amino acid oxidase (DAAO, EC 1.4.3.3) is used in many biotechnological processes. The main industrial application of DAAO is biocatalytic production of 7-aminocephalosporanic acid from cephalosporin C with a two enzymes system. DAAO from the yeast Trigonopsis variabilis (TvDAAO) shows the best catalytic parameters with cephalosporin C among all known
Atroshenko DL, Shelomov MD, Zarubina SA, Negru NY, Golubev IV, Savin SS, Tishkov VI.   +6 more
europepmc   +6 more sources

Biosynthesis of Cephalosporin C [PDF]

Applied Microbiology, 1962
The superiority of d -methionine over l -methionine for stimulation of cephalosporin C synthesis in a crude medium was confirmed. The optimal level of dl -methionine was 0.5%.
Arnold L. Demain, Joanne F. Newkirk
  +6 more sources

Formation of Desacetylcephalosporin C in Cephalosporin C Fermentation [PDF]

Applied Microbiology, 1968
The origin of desacetylcephalosporin C in cephalosporin C fermentation broths was investigated. Esterase activity was detected in cell-free extracts of Cephalosporium acremonium , but these extracts failed to deesterify cephalosporin C. When cephalosporin C was added to sterile and inoculated fermentation media, the
F. M. Huber, Richard H. Baltz, P. G. Caltrider   +2 more
  +6 more sources

Statistical optimization and gamma irradiation on cephalosporin C production by Acremonium chrysogenum W42-I [PDF]

AMB Express, 2023
Most antibiotics now used in clinical practice are cephalosporins. Acremonium (A.) chrysogenum W42-I is an intermediate strain out of W42 strain improvement program whose productivity is above that of the wild-type strain to produce the broad-spectrum ...
Asmaa A. Ibrahim, Ghadir S. El-Housseiny, Khaled M. Aboshanab, Ansgar Startmann, Mahmoud A. Yassien, Nadia A. Hassouna   +5 more
doaj   +2 more sources

A Straightforward Approach to Synthesize 7-Aminocephalosporanic Acid In Vivo in the Cephalosporin C Producer Acremonium chrysogenum [PDF]

Journal of Fungi, 2022
The pharmaceutical industry has developed various highly effective semi-synthetic cephalosporins, which are generated by modifying the side chains of the core molecule 7-aminocephalosporanic acid (7-ACA).
Xuemei Lin, Jan Lambertz, Tim A. Dahlmann, Marc M. Nowaczyk, Burghard König, Ulrich Kück   +5 more
doaj   +2 more sources

Enhancing the production of cephalosporin C through modulating the autophagic process of Acremonium chrysogenum [PDF]

Microbial Cell Factories, 2018
Background Autophagy is used for degradation of cellular components and nutrient recycling. Atg8 is one of the core proteins in autophagy and used as a marker for autophagic detection.
Honghua Li, Pengjie Hu, Ying Wang, Yuanyuan Pan, Gang Liu   +4 more
doaj   +2 more sources

Polyamines Upregulate Cephalosporin C Production and Expression of β-Lactam Biosynthetic Genes in High-Yielding Acremonium chrysogenum Strain [PDF]

Molecules, 2021
The high-yielding production of pharmaceutically significant secondary metabolites in filamentous fungi is obtained by random mutagenesis; such changes may be associated with shifts in the metabolism of polyamines.
Alexander A. Zhgun, Mikhail A. Eldarov
doaj   +2 more sources

Study on genetic engineering of Acremonium chrysogenum, the cephalosporin C producer [PDF]

Synthetic and Systems Biotechnology, 2016
Acremonium chrysogenum is an important filamentous fungus which produces cephalosporin C in industry. This review summarized the study on genetic engineering of Acremonium chrysogenum, including biosynthesis and regulation for fermentation of ...
Youjia Hu, Baoquan Zhu
doaj   +2 more sources

The critical role of plasma membrane H+-ATPase activity in cephalosporin C biosynthesis of Acremonium chrysogenum. [PDF]

PLoS ONE, 2020
The filamentous fungus Acremonium chrysogenum is the main industrial producer of cephalosporin C (CPC), one of the major precursors for manufacturing of cephalosporin antibiotics.
Alexander Zhgun, Mariya Dumina, Ayrat Valiakhmetov, Mikhail Eldarov   +3 more
doaj   +2 more sources