The critical role of plasma membrane H+-ATPase activity in cephalosporin C biosynthesis of Acremonium chrysogenum. [PDF]
PLoS ONE, 2020 The filamentous fungus Acremonium chrysogenum is the main industrial producer of cephalosporin C (CPC), one of the major precursors for manufacturing of cephalosporin antibiotics.
Alexander Zhgun +3 more
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Enhancing the production of cephalosporin C through modulating the autophagic process of Acremonium chrysogenum [PDF]
Microbial Cell Factories, 2018 Background Autophagy is used for degradation of cellular components and nutrient recycling. Atg8 is one of the core proteins in autophagy and used as a marker for autophagic detection.
Honghua Li +4 more
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Study on genetic engineering of Acremonium chrysogenum, the cephalosporin C producer [PDF]
Synthetic and Systems Biotechnology, 2016 Acremonium chrysogenum is an important filamentous fungus which produces cephalosporin C in industry. This review summarized the study on genetic engineering of Acremonium chrysogenum, including biosynthesis and regulation for fermentation of ...
Youjia Hu, Baoquan Zhu
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Metabolic engineering of Acremonium chrysogenum for improving cephalosporin C production independent of methionine stimulation [PDF]
Microbial Cell Factories, 2018 Background Cephalosporin C (CPC) produced by Acremonium chrysogenum is one of the most important drugs for treatment of bacterial infectious diseases. As the major stimulant, methionine is widely used in the industrial production of CPC.
Jiajia Liu +3 more
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Statistical optimization and gamma irradiation on cephalosporin C production by Acremonium chrysogenum W42-I [PDF]
AMB Express, 2023 Most antibiotics now used in clinical practice are cephalosporins. Acremonium (A.) chrysogenum W42-I is an intermediate strain out of W42 strain improvement program whose productivity is above that of the wild-type strain to produce the broad-spectrum ...
Asmaa A. Ibrahim +5 more
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Effects of Inhibitors on the Catalysis and Immobilization of Cephalosporin C Acylase [PDF]
Chemical and Biochemical Engineering Quarterly, 2018 Numerous compounds, including weak bases (e.g., glucosamine, ethylenediamine, and pyridine) and weak acids (e.g., bicarbonate, acetate, propionate, and butyrate), were found to inhibit the catalysis of cephalosporin C acylase (CCA), which is a ...
H. Luo +9 more
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A Straightforward Approach to Synthesize 7-Aminocephalosporanic Acid In Vivo in the Cephalosporin C Producer Acremonium chrysogenum [PDF]
Journal of Fungi, 2022 The pharmaceutical industry has developed various highly effective semi-synthetic cephalosporins, which are generated by modifying the side chains of the core molecule 7-aminocephalosporanic acid (7-ACA).
Xuemei Lin +5 more
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Polyamines Upregulate Cephalosporin C Production and Expression of β-Lactam Biosynthetic Genes in High-Yielding Acremonium chrysogenum Strain [PDF]
Molecules, 2021 The high-yielding production of pharmaceutically significant secondary metabolites in filamentous fungi is obtained by random mutagenesis; such changes may be associated with shifts in the metabolism of polyamines.
Alexander A. Zhgun, Mikhail A. Eldarov
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Scaling up production of cephalosporin C by Acremonium chrysogenum W42-I in a fermenter using submerged fermentation [PDF]
AMB ExpressCephalosporins presently stand as the most extensively utilized antibiotic in clinical settings. Acremonium (A.) chrysogenum is the main strain used in the manufacturing of cephalosporin C (CPC), which offers distinct advantages, including a wide-ranging
Asmaa A. Ibrahim +5 more
doaj +2 more sources
Spermidine and 1,3-Diaminopropane Have Opposite Effects on the Final Stage of Cephalosporin C Biosynthesis in High-Yielding Acremonium chrysogenum Strain. [PDF]
Int J Mol Sci, 2022 Zhgun AA, Eldarov MA.
europepmc +3 more sources