Results 11 to 20 of about 40,632 (234)

Metabolic engineering of Acremonium chrysogenum for improving cephalosporin C production independent of methionine stimulation [PDF]

Microbial Cell Factories, 2018
Background Cephalosporin C (CPC) produced by Acremonium chrysogenum is one of the most important drugs for treatment of bacterial infectious diseases. As the major stimulant, methionine is widely used in the industrial production of CPC.
Jiajia Liu, Wenyan Gao, Yuanyuan Pan, Gang Liu   +3 more
doaj   +2 more sources

Optimization of Cephalosporin C Acylase Immobilization [PDF]

E3S Web of Conferences, 2019
Cephalosporin C Acylase (CCA), the key biocatalyst in one-step enzymatic production of 7- amino cephalosporanic acid (7-ACA), was immobilized by amino-activated carrier (LX-1000HA) and epoxy-activated carriers (ES-103B, LX-1000EPC), and the activity was ...
Tong Shuangming, Zhu Linlin, Wang Xiaona, LI Xi, Chang Yanhong, Luo Hui   +5 more
doaj   +3 more sources

SOME BIOLOGICAL PROPERTIES OF CEPHALOSPORIN C AND A DERIVATIVE [PDF]

British Journal of Pharmacology and Chemotherapy, 1961
Some biological properties of cephalosporin C and of a pyridinium derivative, “cephalosporin CA (pyridine),” were examined. Staphylococci, both penicillinase‐producing and non‐penicillinase‐producing, and some other bacteria tested, were inhibited by 60 to 125 μg cephalosporin C/ml., and 5 to 20 μg cephalosporin CA (pyridine)/ml.
Matthew Jago, N. G. Heatley
openalex   +5 more sources

The telomere-to-telomere chromosome-scale genome assembly of Acremonium chrysogenum [PDF]

Scientific Data
Acremonium chrysogenum is a notable filamentous fungus recognized for its essential contribution to the pharmaceutical sector through the biosynthesis of cephalosporin C (CPC).
Chao Han, Yiping Zhang, Hengyu Liang, Minliang Chen, Jiahuang Li, Zichun Hua   +5 more
doaj   +2 more sources

Biological Assay of Cephalosporin C [PDF]

Journal of General Microbiology, 1962
SUMMARY: A method of assaying the antibiotic cephalosporin C in low concentration in culture fluids by using a strain of Vibrio cholerae is described. The formation of spheroplasts of the test organism in subinhibitory concentrations of the antibiotic and chemically related compounds is discussed.
Jonathan Bond, R.W. Brimblecombe, R. C. Codner   +2 more
openalex   +4 more sources

Application of Transcriptome Analysis for the Exploration of the Mechanism of Methionine Promoting the Synthesis of Cephalosporin C in Acremonium chrysogenum by Employing a Chemically Defined Medium

Fermentation
To better analyze the biosynthesis mechanism of cephalosporin C (CPC) in Acremonium chrysogenum, single-factor omission experiments and Plackett–Burman (PB) experimental design were employed to identify key components in the chemically defined medium ...
Yifan Li, Zhen Chen, Wei Hong, Tao Feng, Xiwei Tian, Ju Chu   +5 more
doaj   +2 more sources

Potent β-lactam-based tyrosyl-DNA phosphodiesterase 1 inhibitors identified by a virtual screen [PDF]

Scientific Reports
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an important therapeutic target. We recently reported several crystal structures of TDP1 with small molecules bound within the catalytic pocket. These molecules bind by forming hydrogen bonds with residues of the
Xue Zhi Zhao, Wenjie Wang, Kiall F. Suazo, Md Rasel Al Mahmud, Keli Agama, George T. Lountos, Thorkell Andresson, Yves Pommier, Terrence R. Burke   +8 more
doaj   +2 more sources

Distribution of cephalosporin-resistant Campylobacter species isolated from meat sold in Abakaliki, Nigeria [PDF]

Open Veterinary Journal
Background: Campylobacter species have been at the forefront of the field as etiologic agents of foodborne gastroenteritis. The importance of animal proteins, especially contaminated meat, in the transmission of Campylobacteriosis cannot be overstated ...
Nnabuife Bernard Agumah, Mustofa Helmi Effendi, Wiwiek Tyasningsih, Adiana Mutamsari Witaningrum, Emmanuel Nnabuike Ugbo, Onyinyechi Blessing Agumah, Riza Zainuddin Ahmad, Chinekwu Sherridan Nwagwu, Agatha Ifunanya Ugbo, Aswin Rafif Khairullah, Ikechukwu Benjamin Moses, Sheila Marty Yanestria, Katty Hendriana Priscilia Riwu, Wasito Wasito   +13 more
doaj   +2 more sources

Resistance to oxyimino-cephalosporins conferred by an alternative mechanism of hydrolysis by the Acinetobacter-derived cephalosporinase-33 (ADC-33), a class C β-lactamase present in carbapenem-resistant Acinetobacter baumannii (CRAb)

mBio
Antimicrobial resistance in Acinetobacter baumannii is partly mediated by chromosomal class C β-lactamases, the Acinetobacter-derived cephalosporinases (ADCs).
Rachel A. Powers, Bradley J. Wallar, Hannah R. Jarvis, Zoe X. Ziegler, Cynthia M. June, Christopher R. Bethel, Andrea M. Hujer, Magdalena A. Taracila, Susan D. Rudin, Kristine M. Hujer, Fabio Prati, Emilia Caselli, Robert A. Bonomo   +12 more
doaj   +2 more sources

Penicillin Binding Protein Substitutions Cooccur with Fluoroquinolone Resistance in Epidemic Lineages of Multidrug-Resistant Clostridioides difficile

mBio, 2023
Clostridioides difficile remains a key cause of healthcare-associated infection, with multidrug-resistant (MDR) lineages causing high-mortality (≥20%) outbreaks.
Kate E. Dingle, Jane Freeman, Xavier Didelot, T. Phuong Quan, David W. Eyre, Jeremy Swann, William D. Spittal, Emma V. Clark, Keith A. Jolley, A. Sarah Walker, Mark H. Wilcox, Derrick W. Crook   +11 more
doaj   +1 more source