Results 11 to 20 of about 85,074 (245)

Comparative Proteomic Analysis of Acremonium chrysogenum Strains: Key Changes Converting the Wild-Type Strain into Antibiotic Cephalosporin C Biofactory [PDF]

Journal of Fungi
Acremonium chrysogenum is the only industrial producer of the antibiotic cephalosporin C (CPC), the starting substance for manufacturing cephalosporins of the first to fifth generations.
Alexander A. Zhgun, Maria V. Dumina, Alexey V. Beletsky, Arthur T. Kopylov, Viktor G. Zgoda   +4 more
doaj   +2 more sources

Multipoint TvDAAO Mutants for Cephalosporin C Bioconversion. [PDF]

Int J Mol Sci, 2019
Atroshenko DL, Shelomov MD, Zarubina SA, Negru NY, Golubev IV, Savin SS, Tishkov VI.   +6 more
europepmc   +3 more sources

The telomere-to-telomere chromosome-scale genome assembly of Acremonium chrysogenum [PDF]

Scientific Data
Acremonium chrysogenum is a notable filamentous fungus recognized for its essential contribution to the pharmaceutical sector through the biosynthesis of cephalosporin C (CPC).
Chao Han, Yiping Zhang, Hengyu Liang, Minliang Chen, Jiahuang Li, Zichun Hua   +5 more
doaj   +2 more sources

Potent β-lactam-based tyrosyl-DNA phosphodiesterase 1 inhibitors identified by a virtual screen [PDF]

Scientific Reports
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an important therapeutic target. We recently reported several crystal structures of TDP1 with small molecules bound within the catalytic pocket. These molecules bind by forming hydrogen bonds with residues of the
Xue Zhi Zhao, Wenjie Wang, Kiall F. Suazo, Md Rasel Al Mahmud, Keli Agama, George T. Lountos, Thorkell Andresson, Yves Pommier, Terrence R. Burke   +8 more
doaj   +2 more sources

Fistulized renal cyst in the stomach: A diagnostic and therapeutic challenge [PDF]

Urology Case Reports
Renal cysts are usually asymptomatic, and superinfection is rare. We report the case of a 90-year-old woman presenting with fever, flank pain, and vomiting. Laboratory tests showed leukocytosis and elevated C-reactive protein.
Ahmed Chaabouni, Hazem Hachicha, Firas Zouari, Mohamed A. Mseddi, Nouri Rebai, Mourad H. Slimen   +5 more
doaj   +2 more sources

Penicillin Binding Protein Substitutions Cooccur with Fluoroquinolone Resistance in Epidemic Lineages of Multidrug-Resistant Clostridioides difficile

mBio, 2023
Clostridioides difficile remains a key cause of healthcare-associated infection, with multidrug-resistant (MDR) lineages causing high-mortality (≥20%) outbreaks.
Kate E. Dingle, Jane Freeman, Xavier Didelot, T. Phuong Quan, David W. Eyre, Jeremy Swann, William D. Spittal, Emma V. Clark, Keith A. Jolley, A. Sarah Walker, Mark H. Wilcox, Derrick W. Crook   +11 more
doaj   +1 more source

Deacetoxycephalosporin C synthase (expandase): Research progress and application potential

Synthetic and Systems Biotechnology, 2021
Cephalosporins play an indispensable role against bacterial infections. Deacetyloxycephalosporin C synthase (DAOCS), also called expandase, is a key enzyme in cephalosporin biosynthesis that epoxides penicillin to form the hexavalent thiazide ring of ...
Xiaofan Niu, Jian Zhang, Xianli Xue, Depei Wang, Lin Wang, Qiang Gao   +5 more
doaj   +1 more source

European intensive care physicians’ experience of infections due to antibiotic-resistant bacteria [PDF]

, 2020
Background Antimicrobial resistance (AMR) compromises the treatment of patients with serious infections in intensive care units (ICUs), and intensive care physicians are increasingly facing patients with bacterial infections with limited or no adequate ...
De Waele, Jan, Friggeri, Arnaud, Garnacho-Montero, José, Gustin, Marie Paule, Jean, Astrid, Kohlenberg, Anke, Lepape, Alain, Monnet, Dominique L., Savey, Anne, Vanhems, Philippe   +9 more
core   +2 more sources

Risk factors for colonization with multidrug-resistant Gram-negative bacteria and Clostridioides difficile in Long Term Care Facilities (LTCFs) residents: the evidence from 27 facilities in a high endemic setting

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionResidency in LTCFs increases the likelihood of colonization with multidrug resistant Gram-negative bacteria (MDR-GNB). We assessed the prevalence and risk factors for enteric colonization by III-generation cephalosporins-resistant and ...
Anna Maria Azzini, Giorgia Be, Giorgia Be, Laura Naso, Lorenza Lambertenghi, Nicola Duccio Salerno, Ilaria Coledan, Ilaria Coledan, Alda Bazaj, Massimo Mirandola, Jessica Miotti, Fulvia Mazzaferri, Simone Accordini, Giuliana Lo Cascio, Giuliana Lo Cascio, Evelina Tacconelli   +15 more
doaj   +1 more source

Antibiotic prophylaxis is associated with subsequent resistant infections in children with an initial extended-spectrum-cephalosporin-resistant Enterobacteriaceae infection [PDF]

, 2017
The objective of this study was to assess the association between previous antibiotic use, particularly long-term prophylaxis, and the occurrence of subsequent resistant infections in children with index infections due to extended-spectrum-cephalosporin ...
Adler, Amanda L, Burnham, Carey-Ann D, Das, Sibani, Elward, Alexis, Kronman, Matthew P, Miles-Jay, Arianna, Newland, Jason G, Qin, Xuan, Selvarangan, Rangaraj, Sullivan, Kaede V, Weissman, Scott J, Zaoutis, Theoklis, Zerr, Danielle M   +12 more
core   +2 more sources