Severe pertussis complicated by pulmonary hypertension in a Moroccan infant: a case report. [PDF]
Belhakim M+6 more
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Cefiderocol "under siege"? Understanding the rise of NDM-mediated resistance to novel agents. [PDF]
Warecki BA+13 more
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Comparison of the efficacy of carbapenems and cephalosporins for postoperative treatment of perforated appendicitis in children. [PDF]
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Patterns of antimicrobial use among hospitalized Veterans with and without a penicillin-class allergy. [PDF]
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Corrigendum: Genomic analysis of carbapenem-resistant <i>Klebsiella pneumoniae</i> blood isolates from nationwide surveillance in South Korea. [PDF]
On Y, Kim JW, Lee J, Yoo JS.
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Associations between antibiotic consumption intensity and extended-spectrum cephalosporin resistance in nursing homes: a retrospective ecological study. [PDF]
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Microbial Degradation of Cephalosporin C
Nature, 1963THE antibiotic, cephalosporin C, is closely related to the penicillin family and displays the same mode of action1. Although cephalosporin C possesses the β-lactam ring—the substrate site of penicillinase action—it is resistant to this enzyme and, in fact, acts as a competitive ...
Joanne F. Newkirk+3 more
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Cephalosporin C undergoes chemical hydrolysis during fermentation at 25°C at a rate of 0.48% per hour to give increasing amounts of 2-(D-4-amino-4-carboxybutyl)thiazole-4-carboxylic acid (compound X). Although the cephalosporin C titer in a fermentation levels off at 160–170h, the total of C+X rises almost linearly up to 200h.
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Cephalosporin C acylase: dream and(/or) reality
Applied Microbiology and Biotechnology, 2013Cephalosporins currently constitute the most widely prescribed class of antibiotics and are used to treat diseases caused by both Gram-positive and Gram-negative bacteria. Cephalosporins contain a 7-aminocephalosporanic acid (7-ACA) nucleus which is derived from cephalosporin C (CephC).
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