Results 21 to 30 of about 40,632 (234)
Deacetoxycephalosporin C synthase (expandase): Research progress and application potential
Synthetic and Systems Biotechnology, 2021 Cephalosporins play an indispensable role against bacterial infections. Deacetyloxycephalosporin C synthase (DAOCS), also called expandase, is a key enzyme in cephalosporin biosynthesis that epoxides penicillin to form the hexavalent thiazide ring of ...
Xiaofan Niu +5 more
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Effects of Inhibitors on the Catalysis and Immobilization of Cephalosporin C Acylase [PDF]
Chemical and Biochemical Engineering Quarterly, 2018 Numerous compounds, including weak bases (e.g., glucosamine, ethylenediamine, and pyridine) and weak acids (e.g., bicarbonate, acetate, propionate, and butyrate), were found to inhibit the catalysis of cephalosporin C acylase (CCA), which is a ...
H. Luo +9 more
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The X-ray analysis of the structure of cephalosporin C [PDF]
Biochemical Journal, 1961 Dorothy Crowfoot Hodgkin, E. N. Maslen
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Frontiers in Cellular and Infection Microbiology, 2023 IntroductionResidency in LTCFs increases the likelihood of colonization with multidrug resistant Gram-negative bacteria (MDR-GNB). We assessed the prevalence and risk factors for enteric colonization by III-generation cephalosporins-resistant and ...
Anna Maria Azzini +15 more
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Evolution of an acylase active on cephalosporin C [PDF]
Protein Science, 2005 AbstractSemisynthetic cephalosporins are synthesized from 7‐amino cephalosporanic acid, which is produced by chemical deacylation or by a two‐step enzymatic process of the natural antibiotic cephalosporin C. The known acylases take glutaryl‐7‐amino cephalosporanic acid as a primary substrate, and their specificity and activity are too low for ...
Pollegioni L +7 more
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Tetrahedron, 1988 AbstractCell free extracts from Cephalosporium acremonium containing deacetoxy/deacetyl cephalosporin C synthetase activities are shown to convert exomethylene cephalosporin C (I) directly to deacetyl cephalosporin C (II), a precursor in the cephalosporin C (III) biosynthesis.
Baldwin, J +3 more
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Fungal Biology and Biotechnology, 2020 Fungal secondary metabolites are synthesized by complex biosynthetic pathways catalized by enzymes located in different subcellular compartments, thus requiring traffic of precursors and intermediates between them. The β-lactam antibiotics penicillin and
Juan F. Martín
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AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
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Antibiotics, 2022 Background: Overuse of fluoroquinolones has led to concerning rates of resistance, particularly among Gram-negative organisms. They are also highly implicated as a risk factor for Clostridioides difficile infection, and reports of other serious adverse ...
Callyn Mariah Wren +4 more
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7-AMINOCEPHALOSPORANIC ACID – PRODUCTION AND SEPARATION
Studia Universitatis Babes-Bolyai Chemia, 2019 Cephalosporins, a large group of β-lactam antibiotics, contain a 7-aminocephalosporanic acid (7-ACA) nucleus which is derived from cephalosporin C, and substitutions of chemical groups or modifications of 7-ACA side-chains resulting in varying ...
Alexandra TUCALIUC +3 more
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