Results 31 to 40 of about 40,632 (234)
Isolation and characterization of selenate resistant mutants of Acremonium chrysogenum
Brazilian Archives of Biology and Technology, 1999 Mutants unable to convert exogenous sulfate to sulfite were isolated using the toxic analogue selenate. Three of twenty-eight isolated mutants were chromate sensitive. They showed a possible lesion in the gene that codes the ATP sulfurylase.
Airton Vialta +3 more
doaj +1 more source
KINETICS OF THE HYDROLYSIS OF CEPHALOSPORIN C
The Journal of Antibiotics, 1973 The decomposion rates of cephalosporin C in aqueous buffers and in fermentation broth at 25°C were determined by high pressure liquid chromatography and were found to obey the rate law -dC/dt=[Q.27 (H+) + 0.005 + 500 (OH-)]Cmole.l-1.h-1. In the acidity range from pH 3 to 7 the principal reaction is the slow attack of water on the nucleus.
Johannes Gruner, J. Konecny, E. Felber
openaire +4 more sources
Frontiers in Microbiology, 2021 Non-typhoidal Salmonella (NTS) typically causes self-limiting diarrheal disease but may occasionally lead to invasive infection. This study investigated the epidemiology and antimicrobial resistance of children with NTS infection between 2012 and 2019 ...
Yi-Jung Chang +10 more
doaj +1 more source
The polarography of cephalosporin C derivatives
Journal of Pharmacy and Pharmacology, 1968 Abstract WE report some preliminary measurements on the polarographic reduction of cephalosporin C, cephalothin [7-(2-thienylacetamido)-cephalosporanic acid] and cephaloridine [7-(2-thienylacetamido)-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid betaine]. Green, Page & Staniforth (1965) have shown that cephalosporin C
C T Rhodes, I F Jones, J E Page
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De novo comparative transcriptome analysis of Acremonium chrysogenum: high-yield and wild-type strains of cephalosporin C producer. [PDF]
PLoS ONE, 2014 β-lactam antibiotics are widely used in clinic. Filamentous fungus Acremonium chrysogenum is an important industrial fungus for the production of CPC, one of the major precursors of β-lactam antibiotics.
Yan Liu +5 more
doaj +1 more source
Modelling of substrate access and substrate binding to cephalosporin acylases
Scientific Reports, 2019 Semisynthetic cephalosporins are widely used antibiotics currently produced by different chemical steps under harsh conditions, which results in a considerable amount of toxic waste. Biocatalytic synthesis by the cephalosporin acylase from Pseudomonas sp.
Valerio Ferrario +3 more
doaj +1 more source
Erythropoietic potential of Parquetina nigrescens in cephalosporin-induced anaemia model
Metabolism Open, 2020 Parquetina nigrescens is a folklore plant in Africa, particularly Nigeria, where its consumption is believed to stimulate red blood cells production. On this basis, the erythropoietic potential of the plant was evaluated in Cephalosporin-induced anaemia ...
O.M. Ighodaro +5 more
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Advanced Science, EarlyView.The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan +5 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Objective The optimum duration of prophylactic antibiotics after pancreaticoduodenectomy following preoperative biliary drainage to prevent surgical site infections remains controversial. We evaluate whether a prolonged course of prophylactic antibiotics reduces surgical site infection after pancreaticoduodenectomy following biliary drainage ...
Kyohei Matsumoto +9 more
wiley +1 more source
An Industrial View on Enzymes for the Cleavage of Cephalosporin C
CHIMIA, 1999 The enzymatic cleavage of cephalosporin C (CephC) into 7-aminocephalosporanic acid (7-ACA) and deacetyl-7-aminocephalosporanic acid (HACA), both key intermediates for cephalosporin antibiotics, has now been commercialized on an industrial scale.
Waander Riethorst, Arno Reichert
doaj +2 more sources