Results 21 to 30 of about 149,559 (362)
New Microbes and New Infections, 2015 Bacterial pellets from Enterobacteriaceae positive blood cultures prepared using ammonium chloride were tested for rapid detection of β-lactamase using the commercial βLACTA test and read after 30 minutes.
Guy Prod'hom +4 more
doaj +1 more source
Beta-Lactam Probability of Target Attainment Success: Cefepime as a Case Study
Antibiotics, 2023 Introduction: Probability of target attainment (PTA) analysis using Monte Carlo simulations has become a mainstay of dose optimization. We highlight the technical and clinical factors that may affect PTA for beta-lactams.
Daniel J. Selig +3 more
doaj +1 more source
Pathogens, 2023 The recommended therapy for severe infections caused by AmpC-inducible Enterobacterales (AmpC-E) typically involves cefepime or carbapenems. In an era of emerging resistance to these antimicrobials, we aim to assess the impact of third-generation ...
Gilles Vossius +8 more
doaj +1 more source
Emerging Infectious Diseases, 2007 The National Antimicrobial Resistance Monitoring System monitors susceptibility among Enterobacteriaceae in humans in the United States. We studied isolates exhibiting decreased susceptibility to quinolones (nalidixic acid MIC >32 µg/mL or ciprofloxacin ...
Jean M. Whichard +8 more
doaj +1 more source
The new fifth-generation cephalosporins – a balance between safety and efficacy [PDF]
Romanian Journal of Pharmaceutical Practice, 2020 Cephalosporins are beta-lactam antibiotics classified into five generations. The newest generation has three representatives: ceftaroline fosamile, the combination ceftolozane/tazobactam (cephalosporin/beta-lactamase inhibitor), and ceftobiprole ...
Aura Rusu, Ioana-Andreea Lungu
doaj +1 more source
SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children [PDF]
, 2018 Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs).
Arasi, Stefania +19 more
core +1 more source
Cephalosporins: A Focus on Side Chains and β-Lactam Cross-Reactivity
Pharmacy, 2019 Cephalosporins are among the most commonly prescribed antibiotic classes due to their wide clinical utility and general tolerability, with approximately 1–3% of the population reporting a cephalosporin allergy.
Saira B. Chaudhry +2 more
semanticscholar +1 more source
The Journal of Clinical Pharmacology, Volume 63, Issue 2, Page 166-171, February 2023., 2023 Abstract ASPECT‐NP, a phase 3 trial of ceftolozane/tazobactam in hospital‐acquired/ventilator‐associated bacterial pneumonia (HABP/VABP), excluded patients with end‐stage renal disease (ESRD). A modeling/simulation approach was undertaken to inform optimal dosing in this population, using previously developed ceftolozane and tazobactam population ...
Hwa‐Ping Feng +7 more
wiley +1 more source
Pharmaceutics, 2021 The aim of this study was to apply molecular epidemiology, antimicrobial surveillance, and PK/PD analysis to guide the antimicrobial treatment of gonococci infections in a region of the north of Spain.
Rodrigo Alonso +7 more
doaj +1 more source
Broad-spectrum β-lactamases among Enterobacteriaceae of animal origin: molecular aspects, mobility and impact on public health [PDF]
, 2010 Broad-spectrum β-lactamase genes (coding for extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases) have been frequently demonstrated in the microbiota of food-producing animals. This may pose a human health hazard since these genes may be present
Butaye, Patrick +7 more
core +1 more source