Results 21 to 30 of about 110,179 (326)
Beta-Lactam Probability of Target Attainment Success: Cefepime as a Case Study
Antibiotics, 2023 Introduction: Probability of target attainment (PTA) analysis using Monte Carlo simulations has become a mainstay of dose optimization. We highlight the technical and clinical factors that may affect PTA for beta-lactams.
Daniel J. Selig +3 more
doaj +1 more source
Pathogens, 2023 The recommended therapy for severe infections caused by AmpC-inducible Enterobacterales (AmpC-E) typically involves cefepime or carbapenems. In an era of emerging resistance to these antimicrobials, we aim to assess the impact of third-generation ...
Gilles Vossius +8 more
doaj +1 more source
The Journal of Clinical Pharmacology, Volume 63, Issue 2, Page 166-171, February 2023., 2023 Abstract ASPECT‐NP, a phase 3 trial of ceftolozane/tazobactam in hospital‐acquired/ventilator‐associated bacterial pneumonia (HABP/VABP), excluded patients with end‐stage renal disease (ESRD). A modeling/simulation approach was undertaken to inform optimal dosing in this population, using previously developed ceftolozane and tazobactam population ...
Hwa‐Ping Feng +7 more
wiley +1 more source
Emerging Infectious Diseases, 2007 The National Antimicrobial Resistance Monitoring System monitors susceptibility among Enterobacteriaceae in humans in the United States. We studied isolates exhibiting decreased susceptibility to quinolones (nalidixic acid MIC >32 µg/mL or ciprofloxacin ...
Jean M. Whichard +8 more
doaj +1 more source
The new fifth-generation cephalosporins – a balance between safety and efficacy [PDF]
Romanian Journal of Pharmaceutical Practice, 2020 Cephalosporins are beta-lactam antibiotics classified into five generations. The newest generation has three representatives: ceftaroline fosamile, the combination ceftolozane/tazobactam (cephalosporin/beta-lactamase inhibitor), and ceftobiprole ...
Aura Rusu, Ioana-Andreea Lungu
doaj +1 more source
Cephalosporins: A Focus on Side Chains and β-Lactam Cross-Reactivity
Pharmacy, 2019 Cephalosporins are among the most commonly prescribed antibiotic classes due to their wide clinical utility and general tolerability, with approximately 1–3% of the population reporting a cephalosporin allergy.
Saira B. Chaudhry +2 more
semanticscholar +1 more source
Pharmaceutics, 2021 The aim of this study was to apply molecular epidemiology, antimicrobial surveillance, and PK/PD analysis to guide the antimicrobial treatment of gonococci infections in a region of the north of Spain.
Rodrigo Alonso +7 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 39, Issue 1, Page 87-94, January 2023., 2023 Abstract Clinical, laboratory, and microbiological features, clinical outcomes, and pyogenic liver abscess (PLA) prognosis evaluation in non‐liver cancer (Non‐LC) and liver cancer patients treated with transarterial chemoembolization (TACE, LC‐TACE). Clinical data of 48 consecutive PLA patients from January 2016 to December 2020 were retrospectively ...
Yi‐Ming Liu +3 more
wiley +1 more source
Stability and Compatibility Aspects of Drugs: The Case of Selected Cephalosporins
Antibiotics, 2021 Intravenous drug incompatibilities are a common cause of medical errors, contributing to ineffective therapy and even life-threatening events. The co-administration of drugs must always be supported by studies confirming compatibility and thus guarantee ...
Szymon Tomczak +6 more
doaj +1 more source