Results 231 to 240 of about 99,790 (306)

Acid ceramidase regulates CD8+ T-cell exhaustion via type I interferon-mediated upregulation of PD-L1. [PDF]

Front Immunol
Hu Z, Abdelrahman H, Elwy A, Kuang F, Dhiman S, Ali S, Marson M, Holnsteiner L, Hamdan TA, Friebus-Kardash J, Wiebeck E, Hansen W, Scheu S, Gulbins E, Lang PA, Lang KS, Lang J.   +16 more
europepmc   +1 more source

SMPD1 as a Potential Prognostic Biomarker in Glioma Is Associated With an Immunosuppressive Microenvironment

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
SMPD1 expression varies across different glioma subtypes and clinical features and is associated with poor prognosis. High SMPD1 levels are linked to an immunosuppressive tumor microenvironment, characterized by suppressed M1 macrophage polarization and enhanced M2‐like signatures.
Yanan Xu, Xing Liu, Boya Xu, Qiuling Li, Luofei Zhang, Cao Li, Zhigang Zhao   +6 more
wiley   +1 more source

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source

Reprogramming offspring liver health: maternal indole supplementation as a preventive strategy against MASLD. [PDF]

EBioMedicine
Mandala A, Undi RB, Janssen RC, Sugino KY, Zhao W, Nelson BN, Teague AM, Patil NY, Zemsky Berry K, Varshney R, Bergman BC, Rudolph MC, Joshi AD, Rajala RVS, Jonscher KR, Friedman JE.   +15 more
europepmc   +1 more source

Dihydromyricetin Regulates PANoptosis to Protect Salmonella Typhimurium‐Infected Weaned Piglets

Food Frontiers, Volume 7, Issue 2, March 2026.
After DHM pretreatment, piglets were subjected to Salmonella infection. Serum and ileocecal samples from the piglets were collected for TUNEL assay, Western blotting analysis, and metabolomics analysis. The results collectively indicated that DHM could protect piglets from Salmonella infection.
Tingting Xiao, Xinyi Tian, YiKun Li, Jie Zhang, Hongcan Huang, Yu‐Xuan Lyu, Baichuan Deng   +6 more
wiley   +1 more source

Regulatory roles of bioactive lipids in vascular homeostasis and remodeling. [PDF]

Med Rev (2021)
Yang J, Xiao H, Zhang Z, Zhang L, Zhang X.   +4 more
europepmc   +1 more source

Nutrigenomics of the Mediterranean Diet: Gene–Diet Interactions and Bioactive Compounds in Cardiovascular Health

Food Frontiers, Volume 7, Issue 2, March 2026.
The Mediterranean diet interacts with genetic and epigenetic backgrounds to modulate nutrigenomic mechanisms, including DNA methylation, histone modification and microRNA regulation. These molecular effects reduce inflammation and oxidative stress, enhance nitric oxide bioavailability and lipid metabolism and translate into improved cardiometabolic ...
Karina Ramírez‐Alarcón, Ana María Labraña, Fernanda Carrasco‐Marín, Pilar Benítez‐Cid, Rafael Zapata‐Lamana, Xavier Capó, Margalida Monserrat‐Mesquida, Antoni Sureda, Héctor Contreras, Francisca Valenzuela‐Mella, Daniel Pacheco Bravo, Daniela Calina, Maria de la Luz Cádiz‐Gurrea, Antonio Segura‐Carretero, William N. Setzer, Javad Sharifi‐Rad, Miquel Martorell   +16 more
wiley   +1 more source

GSK3β promotes p53/Nrf2-dependent expression of the stress response protein REDD2 in retinal Müller glia exposed to hyperlipidemic conditions. [PDF]

Exp Eye Res
VanCleave AM, Sunilkumar S, Toro AL, Kimball SR, Dennis MD.   +4 more
europepmc   +1 more source

Development and in vitro evaluation of chitosan nanoparticles encapsulating Phoenix dactylifera L. (Ajwah) seed extract with supporting in silico molecular docking analysis

Food Biomacromolecules, Volume 3, Issue 1, Page 163-183, March 2026.
Abstract This research describes the engineering of chitosan nanoparticles (CS NPs) via ionic gelation to encapsulate Ajwah seed extract (ASE), repurposing a plant waste product for its documented antioxidant and anticancer potential. Physicochemical analysis confirmed the formation of stable nanoparticles with hydrodynamic diameters between 152.3 and ...
Jailan E. Elhalawani, Amro Shetta, Wael Mamdouh   +2 more
wiley   +1 more source

Increased triacylglyceride and ceramide levels are key for MERS-CoV replication. [PDF]

mSphere
Mitchell HD, Kyle J, Engbrecht K, Berger M, Oxford KL, Sims AC.   +5 more
europepmc   +1 more source