Results 261 to 270 of about 67,708 (303)
Some of the next articles are maybe not open access.
2013
Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) molecule; these mutations result in a defect in chloride secretion in epithelial cell layers. The disease is characterized by severe gastrointestinal and pulmonary symptoms, but it is the pulmonary symptoms that dominate the clinical course of the ...
Grassmé, Heike +2 more
openaire +3 more sources
Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) molecule; these mutations result in a defect in chloride secretion in epithelial cell layers. The disease is characterized by severe gastrointestinal and pulmonary symptoms, but it is the pulmonary symptoms that dominate the clinical course of the ...
Grassmé, Heike +2 more
openaire +3 more sources
2015
Are ceramide molecules capable of self-assembling in biological and phospholipid membranes to form ceramide channels: membrane channels capable to translocating proteins through said membranes? A number of papers have been published which support the conclusion that ceramide forms these large channels in membranes.
openaire +2 more sources
Are ceramide molecules capable of self-assembling in biological and phospholipid membranes to form ceramide channels: membrane channels capable to translocating proteins through said membranes? A number of papers have been published which support the conclusion that ceramide forms these large channels in membranes.
openaire +2 more sources
Molecular Dynamics Simulations of Ceramide and Ceramide-Phosphatidylcholine Bilayers
The Journal of Physical Chemistry B, 2017Recent studies in lipid raft formation and stratum corneum permeability have focused on the role of ceramides (CER). In this study, we use the all-atom CHARMM36 (C36) force field to simulate bilayers using N-palmitoylsphingosine (CER16) or α-hydroxy-N-stearoyl phytosphingosine (CER[AP]) in 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) or 1 ...
Eric Wang, Jeffery B. Klauda
openaire +2 more sources
Constituents of ceramide and ceramide monohexoside in rice bran
Chemistry and Physics of Lipids, 1976Abstract Previous studies in our laboratory [1,2] indicated the existence of ceramides and ceramide monochexosides in brown rice grain. More recently, we have obtained evidence for the presence of these and other sphingolipids (ceramide dihexosides and ceramide trihexosides) in rice bran.
Y. Fujino, M. Ohnishi
openaire +1 more source
Ceramide in Chemotherapy of Tumors
Recent Patents on Anti-Cancer Drug Discovery, 2011It is well known that tumor formation arises from the imbalance between cell death and proliferation. For many years, cancer research has engaged an important part of its efforts to find new therapeutic strategies based on cell death induction. One of the predominant ways to kill tumor cells is to trigger apoptosis by chemotherapy.
Dimanche-Boitrel, Marie-Thérèse +2 more
openaire +5 more sources
A micromethod for the determination of ceramide
Journal of Neuroscience Methods, 1982An enzymatic micromethod for the determination of ceramide is presented. The enzyme, E. coli diglyceride kinase was used to phosphorylate ceramide, as well as diglyceride with high specific activity gamma-[32P]ATP, and the two products are differentiated by their alkali stability.
M, Jones, R W, Keenan
openaire +2 more sources
Ceramide and Ceramide 1 Phosphate in the Brain
2011Ceramide (N-acylsphingosine) forms the backbone of all complex sphingolipids. It is composed of the long-chain sphingoid base, sphingosine, in N-linkage to a variety of acyl groups (varying in length from C14 to C26) (Fig. 8.1). In addition to serving as a precursor to complex sphingolipids, ceramide is a potent signaling molecule capable of regulating
openaire +1 more source
Studies on galactosyl ceramide and lactosyl ceramide β-galactosidase
Chemistry and Physics of Lipids, 1974Abstract Galactosyl ceramide and lactosyl ceramide β-galactosidase activity was measured in extracts of previously frozen human brain. Using the assay methods described here, both galactosyl ceramide and lactosyl ceramide gave Michaelis constants of about 20 μM.
openaire +2 more sources
Ceramide synthesis in the epidermis
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014The epidermis and in particular its outermost layer the stratum corneum provides terrestrial vertebrates with a pivotal defensive barrier against water loss, xenobiotics and harmful pathogens. A vital demand for this epidermal permeability barrier is the lipid-enriched lamellar matrix that embeds the enucleated corneocytes.
Mariona, Rabionet +2 more
openaire +2 more sources