Results 281 to 290 of about 110,293 (352)

Sarcopenia is associated with early postoperative cognitive decline in older adults following hip fracture surgery: a prospective cohort study. [PDF]

BMC Geriatr
Jiang T, Wang P, Wu J, Liang X, Wang Y, Hu X.   +5 more
europepmc   +1 more source

Self‐Assembled Dictamni Cortex Nanoparticles Ameliorate Psoriasis by Epigenetic Modulation of HSP90AB1 and Suppression of the Inflammatory Response

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This study develops self‐assembled Dictamni Cortex (BXP)‐Fe(III) infinite coordination polymer nanoparticles (NB) to improve BXP's solubility and bioavailability for psoriasis. NB transdermally treats psoriasis by targeting the epigenetic regulator CTCF (CCCTC‐binding factor), suppressing HSP90AB1 (heat shock protein 90 alpha family class B member 1 ...
Zhengyi Zhang, Wenqian Du, Xiaojiang Zhang, Hongbo Cui, Baochen Cheng, Xiao Han, Ke He, Tingyi Yin, Xinyi Liu, Ningyi Xian, Ziyang Wang, Meng Liu, Dan Han, Jiankang Liu, Yan Zheng, Ya Wang   +15 more
wiley   +1 more source

Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH. [PDF]

Sci Adv
Yu X, Huang C, Evers M, Liu J, Ting HJ, Zhang S, Chong SY, Tan MS, Wang S, Sayed N, Gao L, Muthiah MD, Soon GST, Wee A, Chow EK, Soh NJH, Pastorin G, Yu VC, Liu B, Dan YY, Torta F, Schiffelers R, Storm G, Wang JW.   +23 more
europepmc   +1 more source

ZDHHC2‐Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao, Wei Li, Yulong Hong, Ruijiang Zeng, Liang Zhu, Lu Yi, Yuan Li, Yinhuai Wang, Haojie Huang, Xuewen Jiang, Xin Jin   +10 more
wiley   +1 more source

Susceptibility to childhood asthma modified by the interactive effects of polycyclic aromatic hydrocarbons exposure and genetic polymorphisms of the aryl hydrocarbon receptor signaling pathway: functional analysis based on lipid metabolism. [PDF]

Respir Res
Tao X, Xu X, Jiang X, Chen M, Bao Y, Cao S, Li L, Yang S, Wu Q.   +8 more
europepmc   +1 more source

Bioinspired Engineering beyond Homeostasis

Advanced Intelligent Systems, Volume 8, Issue 1, January 2026.
This perspective article introduces systems biology as the unifying theoretical framework behind bioinspired engineering. As an example, it explores how disruptions in multiscale biological systems, associated with pathological states, can be viewed as localized failure modes of biological cooperation showing emergent advantages that can inspire ...
Rosalia Moreddu
wiley   +1 more source

Association of plasma ceramides with short-term and lifetime risk of MACE in coronary atherosclerotic heart disease patients: a prospective cohort study. [PDF]

BMJ Open
Li X, Zhang R, Chen X, Bao S, Jiang H.
europepmc   +1 more source

Protein Kinase C Regulates Meiosis in Mammalian Oocytes

BioEssays, Volume 48, Issue 1, January 2026.
Protein kinase C (PKC) participates in the regulation of mammalian oocyte meiosis. PKC is involved in meiosis resumption in prophase I and in the stabilization of meiosis I and meiosis II spindles. PKC stimulates the maturation‐promoting factor during fertilization and stabilizes the mitotic spindle during early embryo development. ABSTRACT The protein
Jaroslav Kalous, Fatima J. Berro, Lucie Nemcova   +2 more
wiley   +1 more source

Impact of C-Terminal PKC Phosphorylation on TRPC6 Current Kinetics. [PDF]

Int J Mol Sci
Keck M, Pöll S, Schmelzer H, Kressmann T, Hermann C, Mederos Y Schnitzler M, Storch U.   +6 more
europepmc   +1 more source

Selection of Host Plasma Membrane Lipids by HIV‐1 Gag Protein

BioEssays, Volume 48, Issue 1, January 2026.
Enrichment of sphingomyelin in the HIV‐1 envelope arises from Gag binding to PI(4,5)P2, which triggers reorganization of plasma membrane sphingomyelin/cholesterol domains through unknown mechanisms. We propose that cholesterol‐mediated interleaflet coupling between sphingomyelin and PI(4,5)P2, rather than interdigitation, underlies Gag‐induced lipid ...
Nario Tomishige, Yves Mély, Toshihide Kobayashi   +2 more
wiley   +1 more source