Results 21 to 30 of about 47,850 (263)

The underpinnings of cerebellar ataxias

Clinical Neurophysiology Practice, 2022
The human cerebellum contains more than 60% of all neurons of the brain. Anatomically, the cerebellum is divided into 10 lobules (I-X). The cerebellar cortex is arranged into three layers: the molecular layer (external), the Purkinje cell layer and the granular layer (internal). Purkinje neurons and interneurons are inhibitory, except for granule cells.
openaire   +3 more sources

Effects of transcranial magnetic stimulation on cerebellar ataxia: A systematic review and meta-analysis

Frontiers in Neurology, 2023
ObjectiveTo determine the effectiveness of transcranial magnetic stimulation in improving cerebellar ataxia.Data sourcesPubMed, EMBASE, the Cochrane Library, Springer, Science Direct, the China National Knowledge Infrastructure (CNKI) and the China ...
Ying Wang, Di Zhang, Ju Wang, Jiang Ma, Li Lu, Song Jin   +5 more
doaj   +1 more source

Progressive Supranuclear Palsy with Predominant Cerebellar Ataxia [PDF]

Journal of Movement Disorders, 2020
Progressive supranuclear palsy (PSP) is characterized by supranuclear gaze palsy, dystonic rigidity of the neck and upper trunk, frequent falls and mild cognitive impairment.
Shoichiro Ando, Masato Kanazawa, Osamu Onodera   +2 more
doaj   +1 more source

Childhood Cerebellar Ataxia [PDF]

Journal of Child Neurology, 2012
Childhood presentations of ataxia, an impairment of balance and coordination caused by damage to or dysfunction of the cerebellum, can often be challenging to diagnose. Presentations tend to be clinically heterogeneous, but key considerations may vary based on the child’s age at onset, the course of illness, and subtle differences in phenotype ...
openaire   +2 more sources

Frequency, characteristics, and immunological accompaniments of ataxia in anti-NMDAR antibody-associated encephalitis

Frontiers in Immunology
IntroductionVery rarely, adult NMDAR antibody-associated encephalitis (NMDAR-E) leads to persistent cerebellar atrophy and ataxia. Transient cerebellar ataxia is common in pediatric NMDAR-E. Immune-mediated cerebellar ataxia may be associated with myelin
Sarah Jesse, Marie Riemann, Hauke Schneider, Marius Ringelstein, Marius Ringelstein, Nico Melzer, Niklas Vogel, Lena Kristina Pfeffer, Manuel A. Friese, Kurt-Wolfram Sühs, Dominica Hudasch, Philipp Schwenkenbecher, Albrecht Günther, Christian Geis, Jonathan Wickel, Martin Lesser, Annika Kather, Frank Leypoldt, Frank Leypoldt, Justina Dargvainiene, Robert Markewitz, Klaus-Peter Wandinger, Franziska S. Thaler, Franziska S. Thaler, Joseph Kuchling, Katharina Wurdack, Lidia Sabater, Lidia Sabater, Carsten Finke, Jan Lewerenz   +29 more
doaj   +1 more source

COQ8A-Ataxia as a Manifestation of Primary Coenzyme Q Deficiency

Metabolites, 2022
COQ8A-ataxia is a mitochondrial disease in which a defect in coenzyme Q10 synthesis leads to dysfunction of the respiratory chain. The disease is usually present as childhood-onset progressive ataxia with developmental regression and cerebellar atrophy ...
Justyna Paprocka, Magdalena Nowak, Piotr Chuchra, Robert Śmigiel   +3 more
doaj   +1 more source

Alcohol induces sensitization to gluten in genetically susceptible individuals: a case control study.

PLoS ONE, 2013
BackgroundThe mechanisms of cerebellar degeneration attributed to prolonged and excessive alcohol intake remain unclear. Additional or even alternative causes of cerebellar degeneration are often overlooked in suspected cases of alcohol-related ataxia ...
Stuart Currie, Nigel Hoggard, Matthew J R Clark, David S Sanders, Iain D Wilkinson, Paul D Griffiths, Marios Hadjivassiliou   +6 more
doaj   +1 more source

Non-progressive cerebellar ataxia and previous undetermined acute cerebellar injury: a mysterious clinical condition

Arquivos de Neuro-Psiquiatria, 2015
Cerebellar ataxias represent a wide group of neurological diseases secondary to dysfunctions of cerebellum or its associated pathways, rarely coursing with acute-onset acquired etiologies and chronic non-progressive presentation.
Wladimir Bocca Vieira de Rezende Pinto, José Luiz Pedroso, Paulo Victor Sgobbi de Souza, Marcus Vinícius Cristino de Albuquerque, Orlando Graziani Povoas Barsottini   +4 more
doaj   +1 more source

Multifaceted and Age-Dependent Phenotypes Associated With Biallelic PNPLA6 Gene Variants: Eight Novel Cases and Review of the Literature

Frontiers in Neurology, 2022
A wide spectrum of neurodegenerative diseases has been associated with pathogenic variants in the PNPLA6 (patatin-like phospholipase domain-containing protein 6) gene, including spastic paraplegia type 39, Gordon—Holmes, Boucher—Neuhauser, Oliver—Mc ...
Lorenzo Nanetti, Daniela Di Bella, Stefania Magri, Mario Fichera, Elisa Sarto, Anna Castaldo, Alessia Mongelli, Silvia Baratta, Silvia Fenu, Marco Moscatelli, Maria Teresa Bonati, Andrea Martinuzzi, Caterina Mariotti, Franco Taroni   +13 more
doaj   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source