Results 41 to 50 of about 161,013 (302)

Cerebellar dysfunction in rodent models with dystonia, tremor, and ataxia

Dystonia, 2023
Dystonia is a movement disorder characterized by involuntary co- or over-contractions of the muscles, which results in abnormal postures and movements. These symptoms arise from the pathophysiology of a brain-wide dystonia network.
Meike E. van der Heijden, Meike E. van der Heijden, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe   +6 more
doaj   +1 more source

Protective activity of aromatic amines and imines against oxidative nerve cell death [PDF]

, 2001
Oxidative stress is a widespread phenomenon in the pathology of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
Behl, Christian, Beyer, Klaus, Moosmann, Bernd, Skutella, Thomas   +3 more
core   +1 more source

Multifaceted and Age-Dependent Phenotypes Associated With Biallelic PNPLA6 Gene Variants: Eight Novel Cases and Review of the Literature

Frontiers in Neurology, 2022
A wide spectrum of neurodegenerative diseases has been associated with pathogenic variants in the PNPLA6 (patatin-like phospholipase domain-containing protein 6) gene, including spastic paraplegia type 39, Gordon—Holmes, Boucher—Neuhauser, Oliver—Mc ...
Lorenzo Nanetti, Daniela Di Bella, Stefania Magri, Mario Fichera, Elisa Sarto, Anna Castaldo, Alessia Mongelli, Silvia Baratta, Silvia Fenu, Marco Moscatelli, Maria Teresa Bonati, Andrea Martinuzzi, Caterina Mariotti, Franco Taroni   +13 more
doaj   +1 more source

Expression in the human brain of retinoic acid induced 1, a protein associated with neurobehavioural disorders [PDF]

, 2014
Acknowledgements Funding was provided by the Wellcome Trust and Tenovus Scotland. Prof Fragoso is the recipient of a Post Doctoral Science without Borders grant from the Brazilian National Council for Scientific and Technological Development (CNPq, 37450/
Fragoso, Yara Dadalti, McCaffery, Peter, Nanescu, Sonia E., Sementilli, Angelo, Sementilli, Pietro, Shearer, Kirsty D., Stoney, Patrick N.   +6 more
core   +2 more sources

Maturation of Human Pluripotent Stem Cell-Derived Cerebellar Neurons in the Absence of Co-culture

Frontiers in Bioengineering and Biotechnology, 2020
The cerebellum plays a critical role in all vertebrates, and many neurological disorders are associated with cerebellum dysfunction. A major limitation in cerebellar research has been the lack of adequate disease models.
Teresa P. Silva, Teresa P. Silva, Evguenia P. Bekman, Evguenia P. Bekman, Evguenia P. Bekman, Tiago G. Fernandes, Sandra H. Vaz, Sandra H. Vaz, Carlos A. V. Rodrigues, Maria Margarida Diogo, Joaquim M. S. Cabral, Maria Carmo-Fonseca   +11 more
doaj   +1 more source

Terra incognita—cerebellar contributions to neuropsychiatric and cognitive dysfunction in behavioral variant frontotemporal dementia [PDF]

, 2015
Although converging evidence has positioned the human cerebellum as an important relay for intact cognitive and neuropsychiatric processing, changes in this large structure remain mostly overlooked in behavioral variant frontotemporal dementia (bvFTD), a
Emma eDevenney, Emma eDevenney, Glenda M Halliday, Glenda M Halliday, John R Hodges, John R Hodges, John R Hodges, Matthew C Kiernan, Matthew C Kiernan, Michael eHornberger, Michael eHornberger, Michael eHornberger, Rachel H Tan, Rachel H Tan   +13 more
core   +2 more sources

Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution

NeuroImage, 2021
The surface of the human cerebellar cortex is much more tightly folded than the cerebral cortex. Volumetric analysis of cerebellar morphometry in magnetic resonance imaging studies suffers from insufficient resolution, and therefore has had limited ...
Chao J. Liu, William Ammon, Viviana Siless, Morgan Fogarty, Ruopeng Wang, Alessia Atzeni, Iman Aganj, Juan Eugenio Iglesias, Lilla Zöllei, Bruce Fischl, Jeremy D. Schmahmann, Hui Wang   +11 more
doaj   +1 more source

A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials [PDF]

, 2017
There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease.
Agresti, C., Buscarinu, Maria Chiara, Calo', Giorgia, Eleuteri, Cecilia, Ferrari, F., Mechelli, Rosella, Olla, S., Ristori, Giovanni, Romano, Silvia, Salvetti, Marco, Umeton, Renato, Veroni, Chiara   +11 more
core   +2 more sources

Isolated Subtle Neurological Abnormalities in Mild Cognitive Impairment Types [PDF]

, 2020
Background: Isolated, subtle neurological abnormalities (ISNA) are commonly seen in aging and have been related to cerebral small vessel disease (SVD) and subcortical atrophy in neurologically and cognitively healthy aging subjects.
Azzarello, Delia, Camarda, Cecilia, Camarda, Rosolino, Cilluffo, Giovanna, Grassedonio, Emanuele, Pipia, Carmela, Sottile, Gianluca, Torelli, Paola   +7 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source