Results 71 to 80 of about 161,013 (302)

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Paraneoplastic anti-Yo antibody mediated subacute cerebellar degeneration. Case series and literature review

Neurologijos seminarai, 2020
Paraneoplastic neurologic syndromes are a subgroup of diseases due to indirect cytotoxic effects of the immune system on specific brain structures rather than the mass effect itself.
M. Vaišvilas , R. Mameniškienė , A. Barkauskienė   +2 more
doaj   +1 more source

Rehabilitation in patients with cerebellar ataxias

Arquivos de Neuro-Psiquiatria, 2022
Cerebellar ataxias comprise a heterogeneous group of diseases characterized by motor and non-motor symptoms, which can be acquired, degenerative, or have a genetic cause, such as spinocerebellar ataxias (SCA).
Hsin Fen Chien, Marise Bueno Zonta, Janini Chen, Giovana Diaferia, Celiana Figueiredo Viana, Hélio Afonso Ghizoni Teive, José Luiz Pedroso, Orlando Graziani Povoas Barsottini   +7 more
doaj   +1 more source

Combined cerebellar and bilateral cervical posterior spinal artery stroke demonstrated on MRI [PDF]

, 2003
Combined cerebellar and spinal ischemic stroke is a rare, critical condition. We report a patient with combined cerebellar and bilateral posterolateral cervical spinal cord infarction due to bilateral stenosis of the vertebral arteries. MRI is the method
Brückmann, H., Hamann, Gerhard F., Liebetrau, M., Müller-Schunk, S., Reich, P., Scheuerer, W.   +5 more
core   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Clinical and genetic correlation of spinocerebellar ataxia patients: Insights from a tertiary care investigation

Annals of Movement Disorders
INTRODUCTION: Spinocerebellar ataxias (SCAs) are a group of neurodegenerative disorders characterized by progressive cerebellar ataxia and various noncerebellar manifestations.
Bashir Sanie, Atif Kawoosa, Ibrar Ahmed Khan, Sheikh Hilal, Zubair Ul Nazir, Adnan Firdaus Raina   +5 more
doaj   +1 more source

Loss of prostatic acid phosphatase and α-synuclein cause motor circuit degeneration without altering cerebellar patterning.

PLoS ONE, 2019
Prostatic acid phosphatase (PAP), which is secreted by prostate, increases in some diseases such as prostate cancer. PAP is also present in the central nervous system. In this study we reveal that α-synuclein (Snca) gene is co-deleted/mutated in PAP null
Maryam Rahimi-Balaei, Matthew Buchok, Pirkko Vihko, Fiona E Parkinson, Hassan Marzban   +4 more
doaj   +1 more source

Delayed cerebellar ataxia induced by Plasmodium falciparum malaria: A rare complication

Clinical Case Reports, 2023
Key Clinical Message In endemic areas, malaria‐induced cerebellar ataxia should be suspected in patients presenting with neurological disorders including slurred speech, tremors, and a sense of imbalance and dizziness while walking.
Emmanuel Edwar Siddig, Sarah Misbah El‐Sadig, Hala Fathi Eltigani, Ahmed Mudawi Musa, Nouh Saad Mohamed, Ayman Ahmed   +5 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Neurological Disease Modelling for Spinocerebellar Ataxia Using Zebrafish

Journal of Experimental Neuroscience, 2019
The cerebellum integrates sensory information and motor actions. Increasing experimental evidence has revealed that these functions as well as the cerebellar cytoarchitecture are highly conserved in zebrafish compared with mammals. However, the potential
Kazuhiko Namikawa, Alessandro Dorigo, Reinhard W Köster   +2 more
doaj   +1 more source