Results 31 to 40 of about 27,277 (291)

Two tests of peripheral blood by standard methods were negative for Von Hippel-Lindau mutations: A case report

Asian Journal of Surgery, 2023
:: Background: Von Hippel-Lindau disease (VHL) is an autosomal dominant, inherited syndrome with variants in the VHL gene causing predisposition to multi-organ benign and malignant neoplasms.
Bing Deng, Chunguang Liu
doaj   +1 more source

Strategies for the Molecular Classification of Medulloblastoma

Biomedicines
Fifteen years ago, an omic study of medulloblastoma revealed the existence of four groups that are biologically and clinically different. Since then, various molecular classification methods have emerged, each with different diagnostic capabilities ...
Josselen Carina Ramírez-Chiquito, Sergio Juárez-Méndez   +1 more
doaj   +1 more source

Pediatric cerebellar pilomyxoid-spectrum astrocytomas

, 2011
Object Pediatric cerebellar astrocytomas with pilomyxoid features include classic pilomyxoid astrocytomas (PMAs) and intermediate pilomyxoid tumors (IPTs). Since the original description of PMA in 1999, most reports in the literature have described PMAs
Jonathan A. Forbes, Rimal Hanif, Bret C. Mobley, Thomas M. O'Lynnger, Calvin M. Cooper, Mahan Ghiassi, Matthew M. Pearson   +6 more
core   +1 more source

Cerebral neoplasm in L-2-hydroxyglutaric aciduria: Two different presentations

, 2020
Background: L-2-hydroxyglutaric aciduria (L2HGA) is a rare neurometabolic disorder characterized by a slowly progressive clinical course, psychomotor and mental retardation, macrocephaly, dysarthria, seizures, and cerebellar and extrapyramidal findings ...
Ero?lu, Nilgün, Şahin, Sevim, Aydın, Kürşad, Dilber, Beril, Havalı, Cengiz, Cansu, Ali   +5 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Case Report: Frontoparietal Metastasis From a Primary Fallopian Tube Carcinoma

Frontiers in Surgery, 2021
Background: Metastatic brain tumors typically arise from primary malignancies of the lung, kidney, breast, skin, and colorectum. Brain metastases originating from malignancies of the female genital tract are extremely rare. We present a case of fallopian
Anthony I. Jang, Joshua D. Bernstock, David J. Segar, Marcello Distasio, Ursula Matulonis, Wenya Linda Bi   +5 more
doaj   +1 more source

Paraneoplastic cerebellar degeneration associated with lymphoepithelial carcinoma of the tonsil

, 2013
Background: Paraneoplastic cerebellar degeneration (PCD) is a classical tumor-associated, immune-mediated disease typically associated with gynecological malignancies, small-cell lung-cancer or lymphoma.
Helmuth Steinmetz, Steinmetz, Helmuth, Henke, Christian, Christian Henke, Sylvia Hartmann, Marcus Middendorp, Hartmann, Sylvia, Johannes Rieger, Ulf Ziemann, Rieger, Johannes, Middendorp, Marcus, Ziemann, Ulf   +11 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Patterns for Differentiation of Posterior Fossa Neoplasms as Detected by Brain Scans

, 1970
SummaryThe histological characteristics of neoplasms that occur in the posterior cranial fossa can often be predicted by a knowledge of the patient’s age and the specific anatomical location of the tumor.
Frank DeLand, A. EveretteJames, Henry Wagner   +2 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source