Paediatric desmoplastic medulloblastoma – Surgical treatment, adjuvant therapy, outcome survival (case series study) [PDF]
Romanian Journal of Neurology, 2020 Background. Desmoplastic medulloblastoma is a common adult cerebellar tumor. It has better than classic medulloblastoma outcome. This is a case series study followed up the cases of paediatric desmoplastic medulloblastoma and their treatment outcome and
Raad Ahmed Hussein +3 more
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RBM5-AS1 promotes radioresistance in medulloblastoma through stabilization of SIRT6 protein
Acta Neuropathologica Communications, 2021 Cancer stem cells (CSCs) contribute to radioresistance in medulloblastoma. Thus, identification of key regulators of medulloblastoma stemness is critical for improving radiotherapy for medulloblastoma.
Chuanying Zhu +3 more
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Analysis of risk factors of medulloblastoma recurrence based on the molecular subgroups
Chinese Journal of Contemporary Neurology and Neurosurgery, 2021 Objective To investigate the recurrence rate and risk factors for the patients with medulloblastoma based on the molecular subgroups. Methods A retrospective study was conducted for the clinicopathological data of 67 medulloblastoma patients who were ...
LIU Hai⁃long +7 more
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PRMT1 is an important factor for medulloblastoma cell proliferation and survival
Biochemistry and Biophysics Reports, 2022 Aberrant expression of protein arginine methyltransferases (PRMTs) has been implicated in a number of brain tumors, but the role of PRMT1 in medulloblastoma, the most common malignant pediatric brain tumor, remains unexplored.
Xiao Gu +8 more
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iScience, 2023 Summary: We show that inactivating AMPK in a genetic medulloblastoma model depletes tumor stem cells and slows progression. In medulloblastoma, the most common malignant pediatric brain tumor, drug-resistant stem cells co-exist with transit-amplifying ...
Daniel Shiloh Malawsky +7 more
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MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence. [PDF]
PLoS ONE, 2010 MicroRNAs (miRNAs) are a class of short non-coding RNAs that regulate cell homeostasis by inhibiting translation or degrading mRNA of target genes, and thereby can act as tumor suppressor genes or oncogenes.
Sujatha Venkataraman +5 more
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Gene expression analyses of the spatio-temporal relationships of human medulloblastoma subgroups during early human neurogenesis. [PDF]
PLoS ONE, 2014 Medulloblastoma is the most common form of malignant paediatric brain tumour and is the leading cause of childhood cancer related mortality. The four molecular subgroups of medulloblastoma that have been identified - WNT, SHH, Group 3 and Group 4 - have ...
Cornelia M Hooper +4 more
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Analytical Cellular Pathology, 2022 Medulloblastoma is one of the most common malignant tumors of the central nervous system in children. Although KIF2B was reported as an oncogene in several malignant tumor types, its role in medulloblastoma has not been studied so far. The PCR results of
Yajun Liu +6 more
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Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth
BMC Cancer, 2011 Background Medulloblastoma is the most common brain tumor in children, and its prognosis is worse than for many other common pediatric cancers. Survivors undergoing treatment suffer from serious therapy-related side effects.
Olson James M +5 more
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Delta-catenin attenuates medulloblastoma cell invasion by targeting EMT pathway
Frontiers in Genetics, 2022 Background: Medulloblastoma is the most common pediatric malignant tumor in central nervous system. Although its prognosis has been improved enormously by the combination treatments with surgery, radiotherapy, and chemotherapy, it still could progress ...
Yuanjun Hu +14 more
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