Results 1 to 10 of about 57,027 (223)
Nature Reviews Disease Primers, 2019 Under the term embryonal tumours, we examine the malignant neoplasms medulloblastomas, CNS-PNETs, AT/RTs, and ETANTRs. The common histological link between them is the small, round, blue cells which appear on H&E stains. They are considered highly malignant tumours (WHO Grade IV), although significant variation of prognosis exists between the ...
Paul A. Northcott +11 more
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Journal of Child Neurology, 2016 Medulloblastoma accounts for nearly 10% of all childhood brain tumors. These tumors occur exclusively in the posterior fossa and have the potential for leptomeningeal spread. Treatment includes a combination of surgery, radiation therapy (in patients >3 years old). Patients >3 years old are stratified based on the volume of postoperative residual
Nathan E, Millard, Kevin C, De Braganca
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Medulloblastoma with extensive nodularity (SHH medulloblastoma) [PDF]
Polish Journal of Pathology, 2018 Medulloblastoma is the most common CNS embryonal tumor and the most common malignant tumor of childhood. Its overall incidence is 1.8 cases per 1 million people, with a childhood incidence of 6 cases per 1 million. 77 percent of patients are less than 19 years old.
Iga Alicja, Fudyma, Nitin R, Wadhwani
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Neurosurgery Clinics of North America, 1990 It is obvious that the past decade has witnessed considerable progress in the management of children with medulloblastoma. Better surgical technique has led to more aggressive surgery with less morbidity. The use of staging has led to reduction in radiation therapy doses in some patients and will, it is hoped, lead to better neuropsychological outcome.
L N, Sutton, R J, Packer, L, Schut
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Metastatic Medulloblastoma [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1974 SUMMARY:The incidence of metastatic medulloblastoma is probably greater than the thirteen documented patients. Case reports of metastatic medulloblastoma must be carefully analysed. We have added two cases which conform to Weiss’ criteria for metastatic disease. The direction and factors influencing spread have been discussed.
D, Parkinson, R T, Ross, C B, Shields
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Pediatric Hematology and Oncology, 1998 Medulloblastomas account for 20% of all primary brain tumors. The vast majority of them are sporadic. Familial medulloblastoma is very rare--only a few cases have been reported worldwide. Most were observed in siblings of the same sex. The affected children presented at various ages and all of them have died, usually within the first 2 years following ...
Moschovi, M +6 more
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Multiomic Medulloblastomas [PDF]
Cancer Cell, 2018 Epigenomics and transcriptomics of medulloblastoma-an important childhood brain tumor-segregate the disease into four clinically relevant subtypes. In this issue of Cancer Cell, Archer et al. and Forget et al. add the proteome to our multiomic map of this disease, revealing posttranscriptional and posttranslational variations with potential therapeutic
Eric P, Rahmann, Richard J, Gilbertson
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Cellular immunotherapy for medulloblastoma
Neuro-Oncology, 2022 AbstractMedulloblastoma (MB) is the most common malignant brain tumor in children, making up ~20% of all primary pediatric brain tumors. Current therapies consist of maximal surgical resection and aggressive radio- and chemotherapy. A third of the treated patients cannot be cured and survivors are often left with devastating long-term side effects ...
Schakelaar, Michael Y +6 more
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Cancer Cell, 2014 Medulloblastoma (MB) is the most common malignant brain tumor in children, where one-third of patients succumb to their disease. This SnapShot describes the classification of MB subgroups, historically by histopathology and currently based on genomic information.
Rusert, Jessica M. +4 more
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Journal of the Pakistan Medical Association, 2020 Medulloblastoma is the most common malignant brain tumour in children and is a major cause of mortality and morbidity, particularly in low- and middle-income countries. It has been risk-stratified on the basis of clinical (age, metastasis and extent of resection) and histological subtypes (classic, desmoplastic and anaplastic).
Naureen, Mushtaq +5 more
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