Results 11 to 20 of about 41,471 (240)

MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence. [PDF]

PLoS ONE, 2010
MicroRNAs (miRNAs) are a class of short non-coding RNAs that regulate cell homeostasis by inhibiting translation or degrading mRNA of target genes, and thereby can act as tumor suppressor genes or oncogenes.
Sujatha Venkataraman, Irina Alimova, Rong Fan, Peter Harris, Nicholas Foreman, Rajeev Vibhakar   +5 more
doaj   +1 more source

Delta-catenin attenuates medulloblastoma cell invasion by targeting EMT pathway

Frontiers in Genetics, 2022
Background: Medulloblastoma is the most common pediatric malignant tumor in central nervous system. Although its prognosis has been improved enormously by the combination treatments with surgery, radiotherapy, and chemotherapy, it still could progress ...
Yuanjun Hu, Yuanjun Hu, Yuanjun Hu, Sihan Zhu, Sihan Zhu, Rizhen Xu, Manxia Wang, Furong Chen, Zeshun Zhang, Binghong Feng, Jian Wang, Zhongping Chen, Zhongping Chen, Jing Wang, Jing Wang   +14 more
doaj   +1 more source

Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner

, 2023
Extracellular vesicles (EVs) have emerged as pivotal mediators of communication in the tumour microenvironment. More specifically, nanosized extracellular vesicles termed exosomes have been shown to contribute to the establishment of a premetastatic ...
Christine Mitoko, Franziska Linke, Hannah K. Jackson, Ian D. Kerr, Beth Coyle, Linke, Franziska, Macarthur, Donald, Coyle, Beth, Jackson, Hannah K., Kerr, Ian D., Donald Macarthur, Mitoko, Christine   +11 more
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Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo

BMC Cancer, 2011
Background Medulloblastoma is the most common brain tumor in children, and its prognosis is worse than for many other common pediatric cancers. Survivors undergoing treatment suffer from serious therapy-related side effects.
Olson James M, Fawcett Paul T, Maduskuie Victoria, Krauthauser Candice, Lee Seung, Rajasekaran Sigrid A   +5 more
doaj   +1 more source

KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway

Analytical Cellular Pathology, 2022
Medulloblastoma is one of the most common malignant tumors of the central nervous system in children. Although KIF2B was reported as an oncogene in several malignant tumor types, its role in medulloblastoma has not been studied so far. The PCR results of
Yajun Liu, Xi Zhang, Ruihan Pan, Xiaolong Liang, Qichang Liu, Chao Yang, Xu Li   +6 more
doaj   +1 more source

Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma

BMC Cancer, 2019
Background MYC amplification or overexpression is common in Group 3 medulloblastoma and is associated with the worst prognosis. Recently, protein arginine methyl transferase (PRMT) 5 expression has been closely associated with aberrant MYC function in ...
Nagendra K. Chaturvedi, Sidharth Mahapatra, Varun Kesherwani, Matthew J. Kling, Mamta Shukla, Sutapa Ray, Ranjana Kanchan, Naveenkumar Perumal, Timothy R. McGuire, J. Graham Sharp, Shantaram S. Joshi, Don W. Coulter   +11 more
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Rare cases of medulloblastoma with hypermutation

Cancer Reports, 2022
Background Medulloblastoma is the most common malignant brain tumor of childhood and is considered a tumor with low mutational burden (~1 Mut/Mb). Therefore, though the medulloblastoma genomes have been extensively characterized in literature, reports on
Aditi Bagchi, Ian Beddows, Albert Cornelius, Giles W. Robinson, Scott D. Jewell   +4 more
doaj   +1 more source

Medulloblastoma with extensive nodularity (SHH medulloblastoma) [PDF]

Polish Journal of Pathology, 2017
Medulloblastoma is the most common CNS embryonal tumor and the most common malignant tumor of childhood. Its overall incidence is 1.8 cases per 1 million people, with a childhood incidence of 6 cases per 1 million. 77 percent of patients are less than 19 years old.
Iga Alicja, Fudyma, Nitin R, Wadhwani
openaire   +2 more sources

Disseminated medulloblastoma in a child with germline BRCA2 6174delT mutation and without Fanconi anemia

Frontiers in Oncology, 2015
Medulloblastoma, the most common malignant brain tumor in children, occurs with increased frequency in individuals with Fanconi anemia who have biallelic germline mutations in BRCA2.
Jingying eXu, Ashley Sloane Margol, Ashley Sloane Margol, Anju eShukla, Xiuhai eRen, Jonathan L Finlay, Jonathan L Finlay, Mark D Krieger, Mark D Krieger, Floyd H Gilles, Floyd H Gilles, Fergus J Couch, Meraj eAziz, Eric T Fung, Shahab eAsgharzadeh, Shahab eAsgharzadeh, Michael T Barrett, Anat eErdreich-Epstein, Anat eErdreich-Epstein   +18 more
doaj   +1 more source

Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature

Case Reports in Pathology, 2020
Medulloblastoma is an embryonal neuroepithelial tumor that affects mainly childhood and more rarely adults. Medulloblastoma occurring as multiple nodules at diagnosis is a rare and tricky presentation.
Irene Troncon, Angela Guerriero, Sabrina Rossi, Monica Ronzon, Marta Padovan, Caccese Mario, Lucia Zanatta, Luisa Toffolatti, Elisabetta Marton, Giuseppe Lombardi, Angelo Paolo Dei Tos, Giuseppe Canova   +11 more
doaj   +1 more source