Results 11 to 20 of about 27,651 (149)
Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma [PDF]
Translational Oncology, 2019 A subset of poor-prognosis medulloblastoma has genomic amplification of MYC. MYC regulates glutamine metabolism in multiple cellular contexts.
Allison R. Hanaford +9 more
doaj +3 more sources
Adult desmoplastic medulloblastoma
Saudi Journal of Medicine and Medical Sciences, 2017 Medulloblastoma is more common in young age and rare in adult age. Some characteristics that characterize medulloblastoma in adults compared with children: Lateral cerebellar location, heterogeneous signal intensity on magnetic resonance imaging ...
Abdulrahman H Al Anazi +3 more
doaj +3 more sources
Nature Reviews Disease Primers, 2019 Under the term embryonal tumours, we examine the malignant neoplasms medulloblastomas, CNS-PNETs, AT/RTs, and ETANTRs. The common histological link between them is the small, round, blue cells which appear on H&E stains. They are considered highly malignant tumours (WHO Grade IV), although significant variation of prognosis exists between the ...
Paul A, Northcott +11 more
+9 more sources
Paediatric desmoplastic medulloblastoma – Surgical treatment, adjuvant therapy, outcome survival (case series study) [PDF]
Romanian Journal of Neurology, 2020 Background. Desmoplastic medulloblastoma is a common adult cerebellar tumor. It has better than classic medulloblastoma outcome. This is a case series study followed up the cases of paediatric desmoplastic medulloblastoma and their treatment outcome and
Raad Ahmed Hussein +3 more
doaj +1 more source
RBM5-AS1 promotes radioresistance in medulloblastoma through stabilization of SIRT6 protein
Acta Neuropathologica Communications, 2021 Cancer stem cells (CSCs) contribute to radioresistance in medulloblastoma. Thus, identification of key regulators of medulloblastoma stemness is critical for improving radiotherapy for medulloblastoma.
Chuanying Zhu +3 more
doaj +1 more source
Analysis of risk factors of medulloblastoma recurrence based on the molecular subgroups
Chinese Journal of Contemporary Neurology and Neurosurgery, 2021 Objective To investigate the recurrence rate and risk factors for the patients with medulloblastoma based on the molecular subgroups. Methods A retrospective study was conducted for the clinicopathological data of 67 medulloblastoma patients who were ...
LIU Hai⁃long +7 more
doaj +1 more source
Journal of Child Neurology, 2016 Medulloblastoma accounts for nearly 10% of all childhood brain tumors. These tumors occur exclusively in the posterior fossa and have the potential for leptomeningeal spread. Treatment includes a combination of surgery, radiation therapy (in patients >3 years old).
Nathan E, Millard, Kevin C, De Braganca
openaire +3 more sources
PRMT1 is an important factor for medulloblastoma cell proliferation and survival
Biochemistry and Biophysics Reports, 2022 Aberrant expression of protein arginine methyltransferases (PRMTs) has been implicated in a number of brain tumors, but the role of PRMT1 in medulloblastoma, the most common malignant pediatric brain tumor, remains unexplored.
Xiao Gu +8 more
doaj +1 more source
iScience, 2023 Summary: We show that inactivating AMPK in a genetic medulloblastoma model depletes tumor stem cells and slows progression. In medulloblastoma, the most common malignant pediatric brain tumor, drug-resistant stem cells co-exist with transit-amplifying ...
Daniel Shiloh Malawsky +7 more
doaj +1 more source
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. [PDF]
, 2017 SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane ...
Bufalieri, Francesca +18 more
core +8 more sources