Results 11 to 20 of about 33,884 (207)
Nature Reviews Disease Primers, 2019 Under the term embryonal tumours, we examine the malignant neoplasms medulloblastomas, CNS-PNETs, AT/RTs, and ETANTRs. The common histological link between them is the small, round, blue cells which appear on H&E stains. They are considered highly malignant tumours (WHO Grade IV), although significant variation of prognosis exists between the ...
Paul A, Northcott +11 more
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Journal of Child Neurology, 2016 Medulloblastoma accounts for nearly 10% of all childhood brain tumors. These tumors occur exclusively in the posterior fossa and have the potential for leptomeningeal spread. Treatment includes a combination of surgery, radiation therapy (in patients >3 years old). Patients >3 years old are stratified based on the volume of postoperative residual
Nathan E, Millard, Kevin C, De Braganca
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Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma
BMC Cancer, 2019 Background MYC amplification or overexpression is common in Group 3 medulloblastoma and is associated with the worst prognosis. Recently, protein arginine methyl transferase (PRMT) 5 expression has been closely associated with aberrant MYC function in ...
Nagendra K. Chaturvedi +11 more
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Case Reports in Pathology, 2020 Medulloblastoma is an embryonal neuroepithelial tumor that affects mainly childhood and more rarely adults. Medulloblastoma occurring as multiple nodules at diagnosis is a rare and tricky presentation.
Irene Troncon +11 more
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Rare cases of medulloblastoma with hypermutation
Cancer Reports, 2022 Background Medulloblastoma is the most common malignant brain tumor of childhood and is considered a tumor with low mutational burden (~1 Mut/Mb). Therefore, though the medulloblastoma genomes have been extensively characterized in literature, reports on
Aditi Bagchi +4 more
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Medulloblastoma with extensive nodularity (SHH medulloblastoma) [PDF]
Polish Journal of Pathology, 2018 Medulloblastoma is the most common CNS embryonal tumor and the most common malignant tumor of childhood. Its overall incidence is 1.8 cases per 1 million people, with a childhood incidence of 6 cases per 1 million. 77 percent of patients are less than 19 years old.
Iga Alicja, Fudyma, Nitin R, Wadhwani
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Frontiers in Oncology, 2015 Medulloblastoma, the most common malignant brain tumor in children, occurs with increased frequency in individuals with Fanconi anemia who have biallelic germline mutations in BRCA2.
Jingying eXu +18 more
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Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era
Frontiers in Oncology, 2020 Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes.
Roberto Carta +18 more
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Neurosurgery Clinics of North America, 1990 It is obvious that the past decade has witnessed considerable progress in the management of children with medulloblastoma. Better surgical technique has led to more aggressive surgery with less morbidity. The use of staging has led to reduction in radiation therapy doses in some patients and will, it is hoped, lead to better neuropsychological outcome.
L N, Sutton, R J, Packer, L, Schut
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Experimental Hematology & Oncology, 2019 Background Medulloblastoma is the most frequently occurring malignant brain tumor in children. Current treatment strategies for medulloblastoma include aggressive surgery, cranio-spinal irradiation and adjuvant chemotherapy.
Shanshan Zhang +7 more
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