Results 31 to 40 of about 27,651 (149)

Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma

BMC Cancer, 2019
Background MYC amplification or overexpression is common in Group 3 medulloblastoma and is associated with the worst prognosis. Recently, protein arginine methyl transferase (PRMT) 5 expression has been closely associated with aberrant MYC function in ...
Nagendra K. Chaturvedi, Sidharth Mahapatra, Varun Kesherwani, Matthew J. Kling, Mamta Shukla, Sutapa Ray, Ranjana Kanchan, Naveenkumar Perumal, Timothy R. McGuire, J. Graham Sharp, Shantaram S. Joshi, Don W. Coulter   +11 more
doaj   +1 more source

Rare cases of medulloblastoma with hypermutation

Cancer Reports, 2022
Background Medulloblastoma is the most common malignant brain tumor of childhood and is considered a tumor with low mutational burden (~1 Mut/Mb). Therefore, though the medulloblastoma genomes have been extensively characterized in literature, reports on
Aditi Bagchi, Ian Beddows, Albert Cornelius, Giles W. Robinson, Scott D. Jewell   +4 more
doaj   +1 more source

Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells [PDF]

, 2018
Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development.
Agnese Po, Andrea Carai, Angela Mastronuzzi, Elisabetta Ferretti, Elisabetta Ferretti, Enrico De Smaele, Evelina Miele, Felice Giangaspero, Felice Giangaspero, Franco Locatelli, Franco Locatelli, Luana Abballe, Marta Moretti, Zein Mersini Besharat   +13 more
core   +9 more sources

Disseminated medulloblastoma in a child with germline BRCA2 6174delT mutation and without Fanconi anemia

Frontiers in Oncology, 2015
Medulloblastoma, the most common malignant brain tumor in children, occurs with increased frequency in individuals with Fanconi anemia who have biallelic germline mutations in BRCA2.
Jingying eXu, Ashley Sloane Margol, Ashley Sloane Margol, Anju eShukla, Xiuhai eRen, Jonathan L Finlay, Jonathan L Finlay, Mark D Krieger, Mark D Krieger, Floyd H Gilles, Floyd H Gilles, Fergus J Couch, Meraj eAziz, Eric T Fung, Shahab eAsgharzadeh, Shahab eAsgharzadeh, Michael T Barrett, Anat eErdreich-Epstein, Anat eErdreich-Epstein   +18 more
doaj   +1 more source

Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature

Case Reports in Pathology, 2020
Medulloblastoma is an embryonal neuroepithelial tumor that affects mainly childhood and more rarely adults. Medulloblastoma occurring as multiple nodules at diagnosis is a rare and tricky presentation.
Irene Troncon, Angela Guerriero, Sabrina Rossi, Monica Ronzon, Marta Padovan, Caccese Mario, Lucia Zanatta, Luisa Toffolatti, Elisabetta Marton, Giuseppe Lombardi, Angelo Paolo Dei Tos, Giuseppe Canova   +11 more
doaj   +1 more source

Machine Learning Decision Tree Models for Differentiation of Posterior Fossa Tumors Using Diffusion Histogram Analysis and Structural MRI Findings. [PDF]

, 2020
We applied machine learning algorithms for differentiation of posterior fossa tumors using apparent diffusion coefficient (ADC) histogram analysis and structural MRI findings.
Aboian, Mariam, Cha, Soonmee, Payabvash, Seyedmehdi, Tihan, Tarik   +3 more
core   +1 more source

A high-throughput screening identifies histone deacetylase inhibitors as therapeutic agents against medulloblastoma

Experimental Hematology & Oncology, 2019
Background Medulloblastoma is the most frequently occurring malignant brain tumor in children. Current treatment strategies for medulloblastoma include aggressive surgery, cranio-spinal irradiation and adjuvant chemotherapy.
Shanshan Zhang, Zhaojian Gong, Peter O. Oladimeji, Duane G. Currier, Qipan Deng, Ming Liu, Taosheng Chen, Yong Li   +7 more
doaj   +1 more source

Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era

Frontiers in Oncology, 2020
Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes.
Roberto Carta, Giada Del Baldo, Evelina Miele, Agnese Po, Zein Mersini Besharat, Francesca Nazio, Giovanna Stefania Colafati, Eleonora Piccirilli, Emanuele Agolini, Martina Rinelli, Mariachiara Lodi, Antonella Cacchione, Andrea Carai, Luigi Boccuto, Luigi Boccuto, Elisabetta Ferretti, Franco Locatelli, Franco Locatelli, Angela Mastronuzzi   +18 more
doaj   +1 more source

Neurodegeneration-associated protein VAPB regulates proliferation in medulloblastoma

Scientific Reports, 2023
VAMP (Vesicle-associated membrane protein)-associated protein B and C (VAPB) has been widely studied in neurodegenerative diseases such as ALS, but little is known about its role in cancer.
Amanda Faria Assoni, Thiago Giove Mitsugi, René Wardenaar, Raiane Oliveira Ferreira, Elisa Helena Farias Jandrey, Gabriela Machado Novaes, Isabela Fonseca de Oliveira Granha, Petra Bakker, Carolini Kaid, Mayana Zatz, Floris Foijer, Oswaldo Keith Okamoto   +11 more
doaj   +1 more source

Using Cystine Knot Proteins as a Novel Approach to Retarget Oncolytic Measles Virus. [PDF]

, 2017
Modified measles virus (MV) has effective oncolytic activity preclinically and is currently being investigated in clinical trials for various types of cancer. We investigated the use of cystine knot proteins (CKPs) to direct MV activity.
Lal, Sangeet, Raffel, Corey
core   +2 more sources