Results 31 to 40 of about 41,471 (240)

Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells.

PLoS ONE, 2019
High morbidity and mortality are common traits of malignant tumours and identification of the cells responsible is a focus of on-going research. Many studies are now reporting the use of antibodies specific to Clusters of Differentiation (CD) cell ...
Jonathan P Robson, Marc Remke, Marcel Kool, Elaine Julian, Andrey Korshunov, Stefan M Pfister, Geoffrey W Osborne, Michael D Taylor, Brandon Wainwright, Brent A Reynolds   +9 more
doaj   +1 more source

Extra-axial Cerebellopontine Angle Adult Medulloblastoma: An Unusual Presentation at an Unusual Site

Indian Journal of Neurosurgery, 2019
Medulloblastoma is a rare adult primary brain tumor and its presence in the cerebellopontine angle (CPA) constitutes an even rarer site for origin. There are only 40 reported cases of CPA medulloblastoma in the literature, with most being intra-axial and
Vishwaraj Ratha, Vikram S. Karmarkar, Chandrashekhar E. Deopujari   +2 more
doaj   +1 more source

Uniformity under in vitro conditions: Changes in the phenotype of cancer cell lines derived from different medulloblastoma subgroups. [PDF]

PLoS ONE, 2017
Medulloblastoma comprises four main subgroups (WNT, SHH, Group 3 and Group 4) originally defined by transcriptional profiling. In primary medulloblastoma tissues, these groups are thought to be distinguishable using the immunohistochemical detection of β-
Petr Chlapek, Karel Zitterbart, Leos Kren, Lenka Filipova, Jaroslav Sterba, Renata Veselska   +5 more
doaj   +1 more source

Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial

, 2015
Purpose: To improve stratification of risk-adapted treatment for non-metastatic (M0), standard-risk medulloblastoma patients by prospective evaluation of biomarkers of reported biological or prognostic significance, alongside clinico-pathological ...
Schwalbe, Ed, Schwalbe, Ed C, Hicks, Debbie, Figarella-Branger, Dominique, Lannering, Birgitta, Clifford, Steven, Nicholson, Sarah, Toole, Kieran O', Lannering, Birgitta,, Clifford, Steven C, zur Mühlen, Anja, Rutkowski, Stefan, O'Toole, Kieran, Goschzik, Tobias, Doz, François, Nicholson, Sarah Leigh, Gustafsson, Göran, Pietsch, Torsten   +17 more
core   +1 more source

Posterior fossa extra-axial variations of medulloblastoma: a pictorial review as a primer for radiologists

Insights into Imaging, 2021
Manifestations of an atypical variant of medulloblastoma of the posterior fossa in extra-axial locations have been reported, and key questions concerning its interpretation have been raised previously. This review illustrated the clinico-radiological and
Abdulaziz M. Al-Sharydah, Abdulrahman Hamad Al-Abdulwahhab, Sari Saleh Al-Suhibani, Wisam M. Al-Issawi, Faisal Al-Zahrani, Faisal Ahmad Katbi, Moath Abdullah Al-Thuneyyan, Tarek Jallul, Faisal Mishaal Alabbas   +8 more
doaj   +1 more source

Ruxolitinib restore chemosensitivity in medulloblastoma resistant cells

, 2022
reservedMedulloblastoma is one of the most common paediatric brain tumor that develops in the cerebellum, with a five-year overall survival under 60%, despite the several clinical therapies.
MIGLIORANZA, PAOLO
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Posterior fossa medulloblastoma in an atypical extra-axial location: A case report

Radiology Case Reports, 2018
Medulloblastoma is the most common posterior fossa tumor of childhood typically within the fourth ventricle. However, extra-axial medulloblastoma in posterior fossa is an uncommon diagnosis.
Elizabeth Presutto, BS, Matthew Chappell, MD, Joseph Fullmer, MD, Sajeev Ezhapilli, MBBS, DNB, DABR   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Chemotherapy reprograms miRNA expression profiles in apoptotic extracellular vesicles from medulloblastoma cells, regulating pro- and anti-proliferative effects on recipient drug-naïve cells

Cell Communication and Signaling
Background Extracellular vesicles (EVs) play a crucial role in intercellular communication. While the effects of EVs released from living or non-dying cancer cells are well characterized, the impact of EVs released from chemotherapy-treated or apoptotic ...
Rosa Mistica C. Ignacio, Helen Forgham, Zerong Ma, Anya Jensen, George Sharbeen, Juanfang Ruan, David S. Ziegler, Maria Tsoli, Phoebe A. Phillips, Chelsea Mayoh, Maria Kavallaris, Joshua McCarroll   +11 more
doaj   +1 more source