Results 51 to 60 of about 57,027 (223)

The Epigenetics of Medulloblastoma

, 2015
Medulloblastoma is the most common malignant pediatric brain tumor arising in the cerebellum or medulla/brain stem. Despite recent treatment advances, approximately 40% of children experience tumor recurrence and 30% will die from the disease.
Vasileios Stathias, Stathias, Vasileios, Allen, Bryce K, Penas, Clara, Ayad, Nagi G, Clara Penas, Bryce K. Allen, Nagi G. Ayad   +7 more
core   +1 more source

Patient‐reported outcomes and medication errors during oral antitumour therapy in paediatrics: Results from the youngAMBORA care programme

British Journal of Clinical Pharmacology, EarlyView.
Aim Increasing use of oral antitumour therapeutics (OAT) in paediatrics is associated with numerous advantages, but also with error‐prone aspects. Based on the randomized AMBORA trial including adults treated with various OAT, we developed a tailored pharmacological/pharmaceutical care programme for children and their caregivers during OAT treatment ...
Phyllis Lensker, Lisa Cuba, Frank Dörje, Martin F. Fromm, Markus Metzler   +4 more
wiley   +1 more source

Hydrocephalus management pathways in pediatric medulloblastoma: a retrospective cohort study. [PDF]

Front Oncol
Ou Y, Xu Y, Yuan J, Zeng H, Li C, Gong J.   +5 more
europepmc   +3 more sources

The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma

Oncogenic events perturb cerebellar development leading to medulloblastoma, a common childhood brain malignancy. Molecular analyses classify medulloblastoma into the WNT, SHH, Group 3 and Group 4 subgroups.
Strell, Carina, Fukui, Rei, Itoh, Yuka, Morén, Anita, Caja, Laia, Nakada, Ayana, Miyazono, Kohei, Tsuchiya, Maiko, Voytyuk, Olesandr, Swartling, Fredrik J., Bergström, Tobias, Wechsler-Reya, Robert J., Hashizume, Yoshinobu, Ali, Mohamad M., イトウ, ユカ, Tsubakihara, Yutaro, Micke, Patrick, 40454326, Heldin, Carl-Henrik, Ohata, Yae, 25036, Martín-Rubio, Paula, Sancho, Patricia, Golán-Cancela, Irene, Moustakas, Aristidis, 伊藤, 友香, Rosén, Gabriela, Voytyuk, Oleksandr, Yamamoto, Kouhei, Morén, Anita,, Ali, Mohamad M.,, Heldin, Carl-Henrik,, Tsubakihara, Yutaro,, Bergström, Tobias,, Voytyuk, Olesandr,, Ohata, Yae,, Itoh, Yuka,, Strell, Carina,, Moustakas, Aristidis,, Nakada, Ayana,, Micke, Patrick,, Caja, Laia,, Golán-Cancela, Irene,, Rosén, Gabriela,, Swartling, Fredrik J.,   +44 more
core   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Medulloblastoma in concurrence with metastatic gastrointestinal stromal tumor: what's the GIST? Illustrative case. [PDF]

J Neurosurg Case Lessons
Leoni JA, Glasser JS, Hundley KN.
europepmc   +2 more sources

Clinical, Radiologic and Cytologic Predictors of Malignancy in Pediatric Thyroid Nodules: Insights From a 26‐Year Cohort Study

Head &Neck, EarlyView.
ABSTRACT Introduction Thyroid nodules are less common but more often malignant in pediatric patients than in adults. Our objectives were to study the features of benign vs. malignant thyroid nodules in a large pediatric patient cohort. Methods Retrospective observational cohort study. Consecutive patients aged 0.01–17.9 years at evaluation between 1997–
Maxime Gest‐Laurent, Adrien Nguyen Quoc, Christine Lefevre, Laura González‐Briceño, Caroline Thalassinos, Isabelle Flechtner, Dulanjalee Kariyawasam, Yamina Dassa, Magali Viaud, Dinane Samara‐Boustani, Graziella Pinto, Hervé Monpeyssen, Sabine Sarnacki, Vincent Couloigner, Michel Polak, Athanasia Stoupa   +15 more
wiley   +1 more source

Research progress on the use of the optical coherence tomography system for the diagnosis and treatment of central nervous system tumors

Ibrain, Volume 11, Issue 1, Page 3-18, Spring 2025.
With the advantages of high‐resolution imaging, efficient image acquisition, intraoperative real‐time detection, and radiation‐free and noninvasive characteristics, optical coherence tomography (OCT) provides accurate diagnosis and effective intraoperative guidance for the minimally invasive diagnosis and treatment of central nervous system (CNS ...
Jiuhong Li, Ziba Ayi, Gonggong Lu, Haibo Rao, Feilong Yang, Jing Li, Jiachen Sun, Junlin Lu, Xulin Hu, Si Zhang, Xuhui Hui   +10 more
wiley   +1 more source

Medulloblastoma: optimizing care with a multidisciplinary approach

, 2019
Alice Thomas,1 Georges Noël1,2 1Radiotherapy Department, Centre Paul Strauss, UNICANCER, F-67065 Strasbourg, France; 2Radiobiology Lab, CNRS, IPHC UMR 7178, Centre Paul Strauss, UNICANCER, F-67000 Strasbourg, France Abstract: Medulloblastoma is a ...
Noël G, Thomas A
core  

High expression of DNA methyltransferases in primary human medulloblastoma

, 2016
Epigenetic alterations have been implicated in cancer development. DNA methylation modulates gene expression, which is catalyzed by DNA methyltransferases (DNMTs).
Eszter Turányi, Peter Hauser, Tímea Pócza, Zsuzsanna Jakab, János Csáthy, Tibor Krenács   +5 more
core   +1 more source