Results 71 to 80 of about 57,027 (223)

Clinical evaluation of the CrossNN DNA methylation classifier for central nervous system tumors

Brain Pathology, EarlyView.
CrossNN demonstrated non‐inferiority to the Heidelberg CNS Tumor Methylation Classifier. A dual‐classifier approach increased the number of clinically informative classifications with correct tumor type assignment while maintaining a low rate of incorrect predictions.
Jonas Dahnoun, Léon C. van Kempen, Senada Koljenović, Ken Op de Beeck, Tomas Menovsky, Bart Feyen, Melek Ahmed, Anne Sieben, Karen Zwaenepoel   +8 more
wiley   +1 more source

Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma

, 2010
PTCH1 and SUFU are both regulators of the sonic hedgehog signalling pathway. Germline inactivating mutations in both genes are associated with multisystem phenotypes including medulloblastoma.
Hanks, Sandra, Walker, Lisa, Jenny Douglas, Murray, Anne, Ajith Kumar, Louise Izatt, Nazneen Rahman, Douglas, Jenny, Ingrid Slade, Charles Stiller, Anne Murray, Lisa Walker, Darren Hargrave, Kumar, Ajith, Hargrave, Darren, Rahman, Nazneen, Slade, Ingrid, Izatt, Louise, Sandra Hanks, Stiller, Charles   +19 more
core   +1 more source

Preclinical Models of Craniospinal Irradiation for Medulloblastoma

, 2020
International audience: Medulloblastoma is an embryonal tumor that shows a predilection for distant metastatic spread and leptomeningeal seeding. For most patients, optimal management of medulloblastoma includes maximum safe resection followed by ...
Jennifer L. Stripay, Thomas E. Merchant, Christopher L. Tinkle, Merchant, Thomas E., Stripay, Jennifer L., Roussel, Martine F., Martine F. Roussel, Tinkle, Christopher L.   +7 more
core   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

From cells to cures : neural stem cells unveil the mechanisms and therapeutic vulnerabilities of SHH-medulloblastoma [Elektronisk resurs]

Cancer initiation and progression is an intricate and multifaceted process starting from normal cells exposed to oncogenic events, progressing to neoplastic clones, and ultimately becoming tumor cells.
Leilei Zhou (18673162), Zhou, L,
core   +1 more source

The relationship between psychosocial risk and neurocognitive functioning early after childhood central nervous system tumour diagnosis

Journal of Neuropsychology, EarlyView.
Abstract Neurocognitive impairments are common in paediatric central nervous system (CNS) tumours and can relate to clinical and demographic factors. The impact of social or environmental factors, such as family psychosocial risk, is less well understood.
Jessica Beamish, Riley M. Damiano, Josephine Drijver, Femke Aarsen, Martha Grootenhuis, Marita Partanen   +5 more
wiley   +1 more source

Genetic Testing Station Provides Increased Access to Germline Genetic Testing for Pediatric Oncology Patients

Journal of Genetic Counseling, Volume 35, Issue 6, December 2026.
ABSTRACT Germline genetic testing in the pediatric oncology population remains under‐utilized, despite evidence that 10%–15% of these patients have an underlying genetic cause. Identifying patients with a genetic predisposition can affect diagnosis, treatment, and future surveillance of the patient and family.
Camille Hamilton, Emily Duan, Mariana Niell‐Swiller, Franceska Bhansali, Alyssa Hoover, Stephanie Bottomley, Naghmeh Dorrani, Christina Palmer, Marisa Lewis, Kathy Woo, Bianca Russell, Julian A. Martinez‐Agosto, Beth Karlan, Noah Federman, Vivian Y. Chang   +14 more
wiley   +1 more source

Phase II treatment of medulloblastoma and pineoblastoma with melphalan: clinical therapy based on experimental models of human medulloblastoma.

, 1989
We conducted a phase II study of intravenous (IV) melphalan in the treatment of children with recurrent medulloblastoma and in the initial treatment of children with poor-prognosis medulloblastoma and pineoblastoma.
S C Schold, S H Bigner, O M Colvin, E C Halperin, N A Vick, M Borowitz, M S Mahaley, H S Friedman, W J Oakes, P C Burger   +9 more
core   +1 more source

Patient‐Derived Organoids and High‐Throughput Drug Screening: Advancing Functional Precision Medicine in Pediatric Cancer

Organ Medicine, EarlyView.
Yiyang Bao, Xingfei Chen, Jingyi Huang, Xiaoyu Lin, Yanlai Tang   +4 more
wiley   +1 more source

β‐Arrestin1 Promotes Prostate Cancer Progression via Modulating ESRP1‐Mediated Alternative Splicing of CD44

MedComm – Oncology, Volume 5, Issue 4, December 2026.
β‐arrestin1 promotes prostate cancer progression by suppressing epithelial splicing regulatory protein 1 (ESRP1) expression and shifting CD44 alternative splicing toward CD44s and away from CD44v2 and CD44v6. These changes accompany increased N‐cadherin, decreased E‐cadherin, and enhanced epithelial–mesenchymal transition.
Sicheng Dong, Minlian Pan, Zhiqing He, Cong Wang, Yuhao Zhou, Jiayin Du, Tianyu Huang, Xue Wang, Xiaofeng Zhou, Zhixiong Zhang, Di Gu, Xiaolu Duan, Mengping Zhang   +12 more
wiley   +1 more source