Results 71 to 80 of about 27,651 (149)
Cancer Cell, 2014 Medulloblastoma (MB) is the most common malignant brain tumor in children, where one-third of patients succumb to their disease. This SnapShot describes the classification of MB subgroups, historically by histopathology and currently based on genomic information.
Rusert, Jessica M. +4 more
openaire +2 more sources
Molecular and clinical correlates of medulloblastoma subgroups: A narrative review
Glioma, 2021 Medulloblastoma is a major cause of cancer-related morbidity and mortality in children, as a significant proportion of patients succumb to their disease and most survivors are left with life-long sequelae of therapy.
Hallie Coltin, Vijay Ramaswamy
doaj +1 more source
In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. [PDF]
, 2016 Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF-κB expression in 51 breast cancer (ductal carcinoma) tissues using immunohistochemistry ...
Bei, R. +13 more
core +1 more source
Analytical Cellular Pathology, 2018 Medulloblastoma is the most common malignant brain tumor of childhood, with great potential to metastasize. However, the mechanisms of how medulloblastoma develops and progresses remain to be elucidated.
Ran Gao +4 more
doaj +1 more source
Immune cell landscape and immunotherapy of medulloblastoma
Pediatric Investigation, 2021 Medulloblastoma is the most common primary pediatric malignancy of the central nervous system. Recurrent and refractory patients account for approximately 30% of them. Immune cells are an important component of the brain tumor microenvironment, including
Jin Zhang, Tianyou Wang
doaj +1 more source
Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth
eLife, 2017 Treatment for medulloblastoma, the most common malignant brain tumor in children, remains limited to surgical resection, radiation, and traditional chemotherapy; with long-term survival as low as 50–60% for Sonic Hedgehog (Shh)-type medulloblastoma.
Tiemo J Klisch +3 more
doaj +1 more source
CREB signaling activity correlates with differentiation and survival in medulloblastoma
Scientific Reports, 2021 While there has been significant progress in the molecular characterization of the childhood brain cancer medulloblastoma, the tumor proteome remains less explored.
Inna Armandari +12 more
doaj +1 more source
Tumor-Associated Macrophages Correlate With Prognosis in Medulloblastoma
Frontiers in Oncology, 2022 PurposeMacrophage polarization plays an essential role in the tumor microenvironment of brain tumors. However, the role of tumor-associated macrophages (TAMs) in medulloblastoma still remains controversial.
Jin Zhang +13 more
doaj +1 more source
Molecular subgroups of adult medulloblastoma: a long-term single-institution study [PDF]
, 2016 Background Recent transcriptomic approaches have demonstrated that there are at least 4 distinct subgroups in medulloblastoma (MB); however, survival studies of molecular subgroups in adult MB have been inconclusive because of small sample sizes. The aim
Ai, Lin +13 more
core +1 more source
A novel role of HLA class I in the pathology of medulloblastoma
Journal of Translational Medicine, 2009 Background MHC class I expression by cancer cells enables specific antigen recognition by the immune system and protection of the host. However, in some cancer types MHC class I expression is associated with an unfavorable outcome.
Rood Brian R +8 more
doaj +1 more source