Results 91 to 100 of about 33,884 (207)

The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics

Clinical Genetics, Volume 110, Issue 3, Page 389-401, September 2026.
The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree, Mark J. Arends, Joseph D. Khoury, Erika R. E. Denton, Anthony J. Gill, Alexander J. Lazar, Ian M. Frayling, Stefan M. Pfister, Mark A. Rubin, Katia R. M. Leite, Raymond Dalgleish, Elspeth A. Bruford, Sharon E. Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D. Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source

Exploiting Integrin-αVβ3 to Enhance Radiotherapy Efficacy in Medulloblastoma via Ferroptosis

Current Oncology
Medulloblastoma, a malignant pediatric brain tumor, has a poor prognosis upon relapse, highlighting a critical clinical need. Our previous research linked medulloblastoma cell radioresistance to integrin-αvβ3 expression.
Célia Gotorbe, Fabien Segui, William Echavidre, Jérôme Durivault, Thays Blanchard, Valérie Vial, Marina Pagnuzzi-Boncompagni, Rémy Villeneuve, Régis Amblard, Nicolas Garnier, Cécile Ortholan, Benjamin Serrano, Vincent Picco, Jacques Pouysségur, Milica Vucetic, Christopher Montemagno   +15 more
doaj   +1 more source

Structure‐Guided Optimization of a Molecular Glue Targeting the KBTBD4‐HDAC1/2 Complex

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Structure‐based optimization of the molecular glue degrader UM171 resulted in a near 20‐fold improvement of ternary complex stability but also revealed the challenges of glue discovery. Optimization of UM171, a molecular glue initiating the degradation of neosubstrate HDAC1/2–CoREST–LSD1 through a multiprotein complex formed with KBTBD4, was carried ...
Timea Balo, Zhuoyao Chen, Laurine Palluaud, Arpad Kiss, Tibor Novak, Andras Herner, Alex N. Bullock, Virginie Martiny, Andras Kotschy   +8 more
wiley   +1 more source

Medulloblastoma (?) [PDF]

Proceedings of the Royal Society of Medicine, 1931
C, Worster-Drought, W E, Dickson
openaire   +2 more sources

Identification of tumor rejection antigens and the immunologic landscape of medulloblastoma

Genome Medicine
Background The current standard of care treatments for medulloblastoma are insufficient as these do not take tumor heterogeneity into account. Newer, safer, patient-specific treatment approaches are required to treat high-risk medulloblastoma patients ...
Changlin Yang, Vrunda Trivedi, Kyle Dyson, Tongjun Gu, Kate M. Candelario, Oleg Yegorov, Duane A. Mitchell   +6 more
doaj   +1 more source

MYC in Oncogenesis and Therapeutic Implications

MedComm, Volume 7, Issue 8, August 2026.
The MYC oncogene family (c‐MYC, N‐MYC, L‐MYC) functions as a central transcriptional hub orchestrating cancer progression through multiple interconnected pathways. This graphical abstract illustrates MYC's role as a multidimensional regulator positioned at the nexus of tumor microenvironment remodeling, metabolic reprogramming, and therapeutic ...
Na Zhang, Li Wei, Cuiping Tang, Peilong Lai, Wenbin Zhong, Hua You   +5 more
wiley   +1 more source

Targeting protein synthesis pathways in MYC-amplified medulloblastoma

Discover Oncology
MYC is one of the most deregulated oncogenic transcription factors in human cancers. MYC amplification/or overexpression is most common in Group 3 medulloblastoma and is positively associated with poor prognosis.
Devendra Kumar, Ranjana Kanchan, Nagendra K. Chaturvedi   +2 more
doaj   +1 more source

Navigating the Psychosocial Journey: A Meta‐Ethnographic Review of the Psychosocial Needs and Experiences of Children and Adolescents (0–19 Years) Diagnosed With Cancer Across the Care Continuum

Psycho-Oncology, Volume 35, Issue 8, August 2026.
ABSTRACT Background Survival rates for childhood cancer have improved; however, psychosocial challenges remain across diagnosis, treatment, and survivorship. Existing qualitative studies typically examine a single phase of care, limiting understanding of how psychosocial needs persist and change over time.
Alyssa Ebert, Carolyn Ee, Oluwaseyifunmi Andi Agbejule, Michael Osborn, Murray Turner, Catherine Paterson   +5 more
wiley   +1 more source

Validity of the Translated Turkish Version of the Tool for Nutrition Risk Screening for Paediatric Cancer

International Journal of Nursing Practice, Volume 32, Issue 4, August 2026.
ABSTRACT Background Malnutrition in paediatric cancer patients increases adverse clinical outcomes; however, methods for assessing malnutrition risk remain unclear. This study aimed to assess the validity of the Nutrition Risk Screening for Pediatric Cancer (NRS‐PC).
Buket Meral, Melda Kangalgil, Erol Erduran   +2 more
wiley   +1 more source

Diagnostic Challenges in Choroid Plexus Tumours

Neuropathology and Applied Neurobiology, Volume 52, Issue 4, August 2026.
In this review, we summarise the diagnostic spectrum of choroid plexus tumours, highlight key age‐dependent differential diagnoses across infants, children/adolescents and adults, and outline how histopathology, immunohistochemistry and molecular profiling support accurate tumour classification.
Christian Thomas, Martin Hasselblatt
wiley   +1 more source