Results 111 to 120 of about 41,471 (240)

Adult medulloblastoma

, 2016
Medulloblastoma is a highly malignant central nervous system (CNS) tumor that arises from the cerebellum. It is the most common primary malignant intracranial childhood neoplasm.
Rege, S. V., Narayan, Sharadendu, Patil, Harshad   +2 more
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Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma

, 2010
PTCH1 and SUFU are both regulators of the sonic hedgehog signalling pathway. Germline inactivating mutations in both genes are associated with multisystem phenotypes including medulloblastoma.
Hanks, Sandra, Walker, Lisa, Jenny Douglas, Murray, Anne, Ajith Kumar, Louise Izatt, Nazneen Rahman, Douglas, Jenny, Ingrid Slade, Charles Stiller, Anne Murray, Lisa Walker, Darren Hargrave, Kumar, Ajith, Hargrave, Darren, Rahman, Nazneen, Slade, Ingrid, Izatt, Louise, Sandra Hanks, Stiller, Charles   +19 more
core   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Expanding the Phenotypic Spectrum Associated With Loss‐of‐Function SMARCA4 Variants to Eye Developmental Anomalies

Clinical Genetics, Volume 109, Issue 6, Page 1064-1069, June 2026.
This study expands the clinical spectrum of SMARCA4 by describing a novel phenotype in three unrelated individuals with truncating variants. Distinct from Coffin–Siris syndrome and rhabdoid tumor predisposition, this new association is characterized by ocular malformations, specifically microphthalmia and coloboma.
Bertrand Chesneau, Marjolaine Willems, Abdelhakim Bouazzaoui, Léopoldine Lequeux, Julie Plaisancié, Salima El Chehadeh, Hélène Dollfus, Nicolas Chassaing   +7 more
wiley   +1 more source

Differences in the Prognostic Value of Tumor Extent of Resection among the Molecular Subgroups of Medulloblastoma: A Single Centre Study of 113 Cases

Brain Science Advances, 2017
Medulloblastoma (MB) is one of the most common pediatrics malignant tumors of the central nervous system. Studies in America and Europe have demonstrated significant differences in the prognostic value of medulloblastoma extent among molecular subgroups ...
Yuyuan Wang, Kay Kawai Li, Ji Xiong, Zhenyu Zhang, Yang Wang, Jian Xu, Yin Wang, Hokeung Ng, Ping Zhong   +8 more
doaj   +1 more source

Incidental Colorectal Adenomas in Adolescents: Clinical Management, Genetic Evaluation, and Surveillance

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1743-1750, June 2026.
Adolescents with incidental colorectal adenomas require age‐conscious management balancing referral for genetic counseling with evidence‐based surveillance. This narrative review proposes a pragmatic clinical algorithm integrating adenoma characteristics, hereditary risk assessment, and guideline‐concordant follow‐up to support individualized ...
Brett J. Hoskins, Shlomi Cohen, Colleen B. Flahive, Isabel Rojas, Aparajita Singh, Thomas M. Attard   +5 more
wiley   +1 more source

Meduloblastomas: esperiência de dez anos no Hospital Infantil Joana de Gusmão. [PDF]

, 2005
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Neves, João Arthur Lange Lins
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Medulloblastoma: From Myth to Molecular

, 2017
Current therapies for medulloblastoma were introduced primarily in the 1980s and consist of predominantly cytotoxic, nontargeted approaches. Mortality from medulloblastoma remains significant.
Michael D. Taylor, Vijay Ramaswamy
core   +1 more source

Nrf2-driven metabolic reprogramming sustains chemotherapy resistance in Medulloblastoma.

reservedMedulloblastoma is one of the most common and aggressive brain tumors in children and is characterized by its high invasiveness. Despite significant advantages in treatment, the resistance to chemotherapies remains an impediment to patient care ...
ZANOLLI, ARIANNA
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