Results 101 to 110 of about 41,471 (240)

Tumor-associated macrophages correlate with better outcome in SHH medulloblastoma

Frontiers in Oncology
ObjectiveTumor-associated macrophages (TAMs) constitute a significant proportion of the immune cell population within brain tumors. The polarization of macrophages exerts an important influence on the tumor microenvironment (TME).
Jin Zhang, Shuting Li, Yuan Wang, Jingjing Liu, Yan Liu, Xiaojun Gong, Yanling Sun, Liming Sun, Zhigang Li, Tianyou Wang, Shuxu Du, Wanshui Wu   +11 more
doaj   +1 more source

Extracellular Vesicles in the Biology and Liquid Biopsy Diagnostics of Pediatric High‐Grade Glioma – Emerging Findings and Opportunities

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Liquid biopsy has emerged as an important diagnostic paradigm impacting care across multiple cancer indications. This is also an area of great interest in pediatric solid tumours, including those affecting the central nervous system (CNS). Of special concern are pediatric high‐grade gliomas (pHGGs) due to the associated diagnostic complexities,
Samia Jahouri, Laura Montermini, Nadim Tawil, Mahsa Jalali, Livia Garzia, Nada Jabado, Janusz Rak   +6 more
wiley   +1 more source

Distinctive MRI Features of Pediatric Medulloblastoma Subtypes

, 2013
OBJECTIVE: We hypothesized that the apparent diffusion coefficient (ADC) and other MRI features can be used to predict medulloblastoma histologic subtypes, as defined by the World Health Organization (WHO) in WHO Classification of Tumours of the Central ...
Andre, Jalal B., Partap, Sonia, Lober, Robert M., Vogel, Hannes, Yeom, Kristen W., Mobley, Bret C., Barnes, Patrick D   +6 more
core   +1 more source

Mapping naturally presented T cell antigens in medulloblastoma based on integrative multi-omics

Nature Communications
Medulloblastoma is the most frequent malignant primary brain tumor in children. Despite recent advances in integrated genomics, the prognosis in children with high-risk medulloblastoma remains devastating, and new tumor-specific therapeutic approaches ...
Julia Velz, Lena K. Freudenmann, Gioele Medici, Marissa Dubbelaar, Malte Mohme, David R. Ghasemi, Jonas Scheid, Daniel J. Kowalewski, Angelica B. Patterson, Anna M. Zeitlberger, Katrin Lamszus, Manfred Westphal, Matthias Eyrich, Martina Messing-Jünger, Andreas Röhrig, Harald Reinhard, Kévin Beccaria, Rogeiro B. Craveiro, Beat M. Frey, Martin Sill, Sven Nahnsen, Marie Gauder, Konstantina Kapolou, Manuela Silginer, Tobias Weiss, Hans-Georg Wirsching, Patrick Roth, Michael Grotzer, Niklaus Krayenbühl, Oliver Bozinov, Luca Regli, Hans-Georg Rammensee, Elisabeth J. Rushing, Felix Sahm, Juliane S. Walz, Michael Weller, Marian C. Neidert   +36 more
doaj   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Characterization of drug-resistant Medulloblastoma models: identification of relevant pathways.

, 2022
non
BOAROLO, GIULIA
core  

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

Ribosomal Proteins in Cell Biology and Cancer

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The functions of ribosomal proteins (RPs) extend beyond the conventional translation process, as they also regulate gene expression, stress responses, and disease progression. Dysregulation of RPs contributes to the onset and progression of various diseases, including cancer and ribosomopathies, underscoring their dual role as critical disease ...
Ao Zhang, Zeguang Sun, Xinyang Song, Xikun Zhou, Jing Li   +4 more
wiley   +1 more source

Inhibition of STAT3: A promising approach to enhancing the efficacy of chemotherapy in medulloblastoma

Translational Oncology
Medulloblastoma is a type of brain cancer that primarily affects children. While chemotherapy has been shown to be effective in treating medulloblastoma, the development of chemotherapy resistance remains a challenge.
Sachindra Kumar, Dube Aakash Arwind, Harish Kumar B, Samyak Pandey, Raksha Nayak, Megh Pravin Vithalkar, Nitesh Kumar, K Sreedhara Ranganath Pai   +7 more
doaj   +1 more source

Development and validation of a nutrition risk screening for patients with childhood cancer in Brazil (NUTRICCAN)

Nutrition in Clinical Practice, Volume 41, Issue 3, Page 768-778, June 2026.
Abstract Background Diagnosing malnutrition in patients with pediatric cancer is challenging because tumor masses can interfere with anthropometric measurements. STRONGkids considers cancer a general risk factor, whereas Screening Tool for Childhood Cancer (SCAN) classifies patients as at risk or not, potentially missing those who need nutrition ...
Cristiane Ferreira Marçon, Carolina Araújo dos Santos, Fernanda Luisa Ceragioli Oliveira   +2 more
wiley   +1 more source