Results 61 to 70 of about 41,471 (240)
Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth
eLife, 2017 Treatment for medulloblastoma, the most common malignant brain tumor in children, remains limited to surgical resection, radiation, and traditional chemotherapy; with long-term survival as low as 50–60% for Sonic Hedgehog (Shh)-type medulloblastoma.
Tiemo J Klisch +3 more
doaj +1 more source
International Journal of Cancer, EarlyView.ABSTRACT The standard for assessing and recording the extent of the tumour, a necessity for most malignancies, is the Tumour Node Metastases (TNM) classification. The Union for International Cancer Control (UICC) TNM committee has defined this since the early 1950s.
James D. Brierley +8 more
wiley +1 more source
Identification of a novel inherited ALK variant M1199L in the WNT type of medulloblastoma
, 2016 Rearrangements involving the ALK gene were identified in a variety of cancers, including paediatric tumour neuroblastoma where presence of ALK expression is also associated with adverse prognosis.
Maria Łastowska +7 more
core +1 more source
A novel role of HLA class I in the pathology of medulloblastoma
Journal of Translational Medicine, 2009 Background MHC class I expression by cancer cells enables specific antigen recognition by the immune system and protection of the host. However, in some cancer types MHC class I expression is associated with an unfavorable outcome.
Rood Brian R +8 more
doaj +1 more source
Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Mass Spectrometry Reviews, EarlyView.Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
Clinical and magnetic resonance imaging findings of a cerebellar medulloblastoma in a heifer [PDF]
, 2019 Key Clinical Message Reports of medulloblastoma in cattle are scarce; however, this neoplasm should be included as a differential diagnosis in cases of cerebellar or central vestibular signs in young cattle.
Orr, Jayne +7 more
core +1 more source
Medulloblastoma – case presentation in an adult patient [PDF]
Romanian Journal of Neurology, 2015 The medulloblastoma is an infratentorial, rapidly growing embryonic tumor that arises in the posterior part of the cerebellar vermis and neuroepithelial roof of the fourth ventricle.
Adina Roceanu +2 more
doaj +1 more source
Central Nervous System Tumors in Xeroderma Pigmentosum: Five Cases and Review of the Literature
Movement Disorders, EarlyView.Abstract Background Xeroderma pigmentosum (XP) is a rare autosomal recessive DNA‐repair disorder characterized by extreme ultraviolet radiation (UVR) sensitivity, markedly increased cutaneous malignancy risk, and progressive neurological disease in approximately one‐third of patients.
Farrah S. Bakr +4 more
wiley +1 more source
FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts
Scientific Reports, 2018 Group 3 tumors account for 28% of medulloblastomas and have the worst prognosis. FTY720, an immunosuppressant currently approved for treatment of multiple sclerosis, has shown antitumor effects in several human cancer cell lines.
Evan F. Garner +8 more
doaj +1 more source
Cancer Medicine, 2023 Background Atypical teratoid rhabdoid tumor (AT/RT) occurs at a younger age and is associated with a worse prognosis than medulloblastoma; however, these two tumor entities are mostly indistinguishable on neuroimaging.
Hsin‐Wei Wu +7 more
doaj +1 more source