Results 61 to 70 of about 27,651 (149)

Maml1 acts cooperatively with Gli proteins to regulate Sonic hedgheog signaling pathway [PDF]

, 2017
Sonic hedgehog (Shh) signaling is essential for proliferation of cerebellar granule cell progenitors (GCPs) and its misregulation is linked to various disorders, including cerebellar cancer medulloblastoma.
BELLAVIA, Diana, BUFALIERI, FRANCESCA, CHECQUOLO, Saula, DI MARCOTULLIO, LUCIA, FELLI, MARIA PIA, LAUER, DIETER MATTHIAS, NARDOZZA, FRANCESCA, PALERMO, ROCCO, PELULLO, MARIA, QUARANTA, ROBERTA, SCREPANTI, Isabella, TALORA, Claudio, VACCA, Alessandra, ZEMA, SABRINA   +13 more
core   +1 more source

Medulloblastoma with extensive nodularity (SHH medulloblastoma) [PDF]

Polish Journal of Pathology, 2017
Medulloblastoma is the most common CNS embryonal tumor and the most common malignant tumor of childhood. Its overall incidence is 1.8 cases per 1 million people, with a childhood incidence of 6 cases per 1 million. 77 percent of patients are less than 19 years old.
Iga Alicja, Fudyma, Nitin R, Wadhwani
openaire   +2 more sources

Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma [PDF]

, 2012
Basal cell carcinoma (BCC) of the skin is the most common type of cancer, and accounts for up to 40% of all cancers in the United States with a growing incidence rate in the last decades in all developed countries.
CUCCHI, DANILO, DE SMAELE, Enrico, GULINO, Alberto, OCCHIONE, MARIA ANNA   +3 more
core   +3 more sources

Posterior fossa medulloblastoma in an atypical extra-axial location: A case report

Radiology Case Reports, 2018
Medulloblastoma is the most common posterior fossa tumor of childhood typically within the fourth ventricle. However, extra-axial medulloblastoma in posterior fossa is an uncommon diagnosis.
Elizabeth Presutto, BS, Matthew Chappell, MD, Joseph Fullmer, MD, Sajeev Ezhapilli, MBBS, DNB, DABR   +3 more
doaj   +1 more source

Turning off the switch in medulloblastoma. The inhibitory acetylation of an oncogene [PDF]

, 2010
[No abstract ...
CANETTIERI, Gianluca, CONI, SONIA, DI MARCOTULLIO, LUCIA, GRECO, Azzura, GULINO, Alberto   +4 more
core   +1 more source

The long noncoding RNA linc-NeD125 controls the expression of medulloblastoma driver genes by microRNA sponge activity [PDF]

, 2017
Long noncoding RNAs (lncRNAs) are major regulators of physiological and disease-related gene expression, particularly in the central nervous system. Dysregulated lncRNA expression has been documented in several human cancers, and their tissue-specificity
Alfano, Vincenzo, Bevilacqua, Valeria, Bozzoni, Irene, Caffarelli, Elisa, Carai, Andrea, Carlo, Valerio Di, Favia, Annarita, Ferretti, Elisabetta, Laneve, Pietro, Legnini, Ivano, Locatelli, Franco, Mastronuzzi, Angela, Miele, Evelina, Po, Agnese, Rea, Jessica   +14 more
core   +1 more source

Chemotherapy reprograms miRNA expression profiles in apoptotic extracellular vesicles from medulloblastoma cells, regulating pro- and anti-proliferative effects on recipient drug-naïve cells

Cell Communication and Signaling
Background Extracellular vesicles (EVs) play a crucial role in intercellular communication. While the effects of EVs released from living or non-dying cancer cells are well characterized, the impact of EVs released from chemotherapy-treated or apoptotic ...
Rosa Mistica C. Ignacio, Helen Forgham, Zerong Ma, Anya Jensen, George Sharbeen, Juanfang Ruan, David S. Ziegler, Maria Tsoli, Phoebe A. Phillips, Chelsea Mayoh, Maria Kavallaris, Joshua McCarroll   +11 more
doaj   +1 more source

The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease. [PDF]

, 2016
Sonic hedgehog (Shh) signaling occurs concurrently with the many processes that constitute nervous system development. Although Shh is mostly known for its proliferative and morphogenic action through its effects on neural stem cells and progenitors, it ...
Belgacem, Yesser H, Borodinsky, Laura N, Hamilton, Andrew M, Shim, Sangwoo, Spencer, Kira A   +4 more
core   +2 more sources

Childhood Medulloblastoma

Journal of the Pakistan Medical Association, 2020
Medulloblastoma is the most common malignant brain tumour in children and is a major cause of mortality and morbidity, particularly in low- and middle-income countries. It has been risk-stratified on the basis of clinical (age, metastasis and extent of resection) and histological subtypes (classic, desmoplastic and anaplastic).
Naureen, Mushtaq, Shahzadi, Resham, Shahzad, Shamim, Bilal Mazhar, Qureshi, Quratulain, Riaz, Eric, Bouffet   +5 more
openaire   +3 more sources

Targeting H3K27me3 demethylase to inhibit Shh signaling and cholesterol metabolism in medulloblastoma growth

Frontiers in Oncology, 2022
Previously we uncovered the epigenetic regulation of medulloblastoma that low levels of H3K27me3 are required for Shh target gene expression and medulloblastoma growth.
Hongshi Deng, Xueli Guo, Na Feng, Yi Luo, Bei Liu, Shuzhen Liu, Jiang I. Wu, Xuanming Shi, Xuanming Shi   +8 more
doaj   +1 more source