Results 21 to 30 of about 27,651 (149)

Gene expression analyses of the spatio-temporal relationships of human medulloblastoma subgroups during early human neurogenesis. [PDF]

PLoS ONE, 2014
Medulloblastoma is the most common form of malignant paediatric brain tumour and is the leading cause of childhood cancer related mortality. The four molecular subgroups of medulloblastoma that have been identified - WNT, SHH, Group 3 and Group 4 - have ...
Cornelia M Hooper, Susan M Hawes, Ursula R Kees, Nicholas G Gottardo, Peter B Dallas   +4 more
doaj   +1 more source

MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence. [PDF]

PLoS ONE, 2010
MicroRNAs (miRNAs) are a class of short non-coding RNAs that regulate cell homeostasis by inhibiting translation or degrading mRNA of target genes, and thereby can act as tumor suppressor genes or oncogenes.
Sujatha Venkataraman, Irina Alimova, Rong Fan, Peter Harris, Nicholas Foreman, Rajeev Vibhakar   +5 more
doaj   +1 more source

Anomalous vascularization in a Wnt medulloblastoma: A case report [PDF]

, 2016
BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children. To date only few cases of medulloblastoma with hemorrhages have been reported in the literature.
Cacchione, Antonella, Carai, Andrea, Colafati, Giovanna Stefania, Dell'Anna, Vito Andrea, Di Giannatale, Angela, Diomedi Camassei, Francesca, Ferretti, Elisabetta, Locatelli, Franco, Marrazzo, Antonio, Mastronuzzi, Angela, Miele, Evelina, Po, Agnese   +11 more
core   +2 more sources

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma [PDF]

, 2013
Medulloblastoma is the most common malignant brain tumor of childhood, and represents a significant clinical challenge in pediatric oncology, since overall survival currently remains under 70%.
Althof, Kristina, Beckers, Anneleen, Eggert, Angelika, El-Hindy, Nicolai, Fleischhack, Gudrun, Henssen, Anton, Heukamp, Lukas, Odersky, Andrea, Schramm, Alexander, Schulte, Johannes H, Schäfers, Simon, Speleman, Franki, Sure, Ulrich, Thor, Theresa   +13 more
core   +4 more sources

Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo

BMC Cancer, 2011
Background Medulloblastoma is the most common brain tumor in children, and its prognosis is worse than for many other common pediatric cancers. Survivors undergoing treatment suffer from serious therapy-related side effects.
Olson James M, Fawcett Paul T, Maduskuie Victoria, Krauthauser Candice, Lee Seung, Rajasekaran Sigrid A   +5 more
doaj   +1 more source

KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway

Analytical Cellular Pathology, 2022
Medulloblastoma is one of the most common malignant tumors of the central nervous system in children. Although KIF2B was reported as an oncogene in several malignant tumor types, its role in medulloblastoma has not been studied so far. The PCR results of
Yajun Liu, Xi Zhang, Ruihan Pan, Xiaolong Liang, Qichang Liu, Chao Yang, Xu Li   +6 more
doaj   +1 more source

Delta-catenin attenuates medulloblastoma cell invasion by targeting EMT pathway

Frontiers in Genetics, 2022
Background: Medulloblastoma is the most common pediatric malignant tumor in central nervous system. Although its prognosis has been improved enormously by the combination treatments with surgery, radiotherapy, and chemotherapy, it still could progress ...
Yuanjun Hu, Yuanjun Hu, Yuanjun Hu, Sihan Zhu, Sihan Zhu, Rizhen Xu, Manxia Wang, Furong Chen, Zeshun Zhang, Binghong Feng, Jian Wang, Zhongping Chen, Zhongping Chen, Jing Wang, Jing Wang   +14 more
doaj   +1 more source

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis [PDF]

, 2018
Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer.
Alfonsi, Romina, Bernardi, Flavia, Bufalieri, Francesca, Canettieri, Gianluca, Capalbo, Carlo, Coni, Sonia, De Smaele, Enrico, Di Marcotullio, Lucia, Faedda, Roberta, Ferretti, Elisabetta, Guardavaccaro, Daniele, Gulino, Alberto, Infante, Paola, Kool, Marcel, Lospinoso Severini, Ludovica, Maroder, Marella, Mazzà, Daniela, Mori, Mattia, Petroni, Marialaura, Pfister, Stefan M., Po, Agnese, Screpanti, Isabella, Siler, Mariangela   +22 more
core   +5 more sources

Medulloblastomas

Neurosurgery Clinics of North America, 1990
It is obvious that the past decade has witnessed considerable progress in the management of children with medulloblastoma. Better surgical technique has led to more aggressive surgery with less morbidity. The use of staging has led to reduction in radiation therapy doses in some patients and will, it is hoped, lead to better neuropsychological outcome.
L N, Sutton, R J, Packer, L, Schut
openaire   +2 more sources

Metastatic Medulloblastoma [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1974
SUMMARY:The incidence of metastatic medulloblastoma is probably greater than the thirteen documented patients. Case reports of metastatic medulloblastoma must be carefully analysed. We have added two cases which conform to Weiss’ criteria for metastatic disease. The direction and factors influencing spread have been discussed.
D, Parkinson, R T, Ross, C B, Shields
openaire   +2 more sources