Results 101 to 110 of about 445,217 (392)

Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications

Cerebellum, 2018
Time perception is an essential element of conscious and subconscious experience, coordinating our perception and interaction with the surrounding environment.
M. Bareš, R. Apps, L. Avanzino, Assaf Breska, E. D’Angelo, P. Filip, M. Gerwig, R. Ivry, C. Lawrenson, E. Louis, Nicholas A. Lusk, M. Manto, W. Meck, H. Mitoma, Elijah A. Petter   +14 more
semanticscholar   +1 more source

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

Norepinephrine release in the cerebellum contributes to aversive learning

Nature Communications, 2023
The modulation of dopamine release from midbrain projections to the striatum has long been demonstrated in reward-based learning, but the synaptic basis of aversive learning is far less characterized.
Adrien T. Stanley, Michael R. Post, Clay Lacefield, David Sulzer, Maria Concetta Miniaci   +4 more
doaj   +1 more source

The neurocognitive gains of diagnostic reasoning training using simulated interactive veterinary cases [PDF]

, 2019
The present longitudinal study ascertained training-associated transformations in the neural underpinnings of diagnostic reasoning, using a simulation game named “Equine Virtual Farm” (EVF).
Nassar, Maaly
core   +1 more source

Classical conditioning drives learned reward prediction signals in climbing fibers across the lateral cerebellum

bioRxiv, 2019
Classical models of cerebellar learning posit that climbing fibers operate according to a supervised learning rule to instruct changes in motor output by signaling the occurrence of movement errors.
W. Heffley, Court Hull
semanticscholar   +1 more source

ON TUMOURS OF THE CEREBELLUM. [PDF]

The Lancet, 1880
n ...
openaire   +2 more sources

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Mild Neonatal Brain Hypoxia-Ischemia in Very Immature Rats Causes Long-Term Behavioral and Cerebellar Abnormalities at Adulthood

Frontiers in Physiology, 2019
Systemic hypoxia-ischemia (HI) often occurs during preterm birth in human. HI induces injuries to hinder brain cells mainly in the ipsilateral forebrain structures.
Eduardo Farias Sanches, Yohan van de Looij, Yohan van de Looij, Audrey Toulotte, Stéphane Vladimir Sizonenko, Hongxia Lei   +5 more
doaj   +1 more source

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors [PDF]

, 2018
In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development.
Atsu Aiba, Cristina Zappulla, Ferdinando Nicoletti, Francesca Liberatore, Giada Mascio, Giorgio Carmignoto, Giuseppe Battaglia, Harumi Nakao, Marta Motolese, Masahiko Watanabe, Micaela Zonta, Michele Madonna, Milena Cannella, Pamela Scarselli, Roberto Gradini, Serena Notartomaso, Valeria Bruno   +16 more
core   +2 more sources

Synchrotron Radiation‐Based Tomography of an Entire Mouse Brain with Sub‐Micron Voxels: Augmenting Interactive Brain Atlases with Terabyte Data

Advanced Science, EarlyView.
Extended‐field acquisition enables sub‐micron X‐ray imaging of a full mouse brain. The 3.3‐teravoxel volume is reconstructed, registered to a reference atlas, and stored in hierarchical format to augment currently available atlases and improve resolution in the third dimension by an order of magnitude.
Mattia Humbel, Christine Tanner, Marta Girona Alarcón, Georg Schulz, Timm Weitkamp, Mario Scheel, Vartan Kurtcuoglu, Bert Müller, Griffin Rodgers   +8 more
wiley   +1 more source