Results 231 to 240 of about 354,424 (374)

Effects of Dictyophora polysaccharide on cerebellar Purkinje cell degeneration in a chronic alcohol mouse model

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In an ethanol (EtOH)‐treated mouse model, increases in the NLRP3 inflammasome proteins, PC degeneration, and motor coordination disorders were observed. DIP suppressed the NLRP3‐ASC‐caspase‐1 signaling pathway, and alleviated the motor deficits and cerebellar pathological changes in chronic EtOH‐treated mice.
Jian Zhang   +5 more
wiley   +1 more source

Eph and ephrin signaling in the development of the central auditory system

open access: yesDevelopmental Dynamics, Volume 252, Issue 1, Page 10-26, January 2023., 2023
Abstract Acoustic communication relies crucially on accurate interpretation of information about the intensity, frequency, timing, and location of diverse sound stimuli in the environment. To meet this demand, neurons along different levels of the auditory system form precisely organized neural circuits.
Jakub Krasewicz, Wei‐Ming Yu
wiley   +1 more source

Neuroimaging Predictors of Cognitive Resilience against Alzheimer's Disease Pathology

open access: yesAnnals of Neurology, EarlyView.
Objective Some individuals demonstrate greater cognitive resilience—the ability to maintain cognitive performance despite adverse brain‐related changes—through as yet unknown mechanisms. We examined whether cortical thickness in several brain regions confers resilience against cognitive decline in amyloid‐positive adults by moderating the effects of ...
McKenna E. Williams   +7 more
wiley   +1 more source

Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement. [PDF]

open access: yesMol Neurodegener
Grima N   +9 more
europepmc   +1 more source

Validating the Accuracy of Parkinson's Disease Clinical Diagnosis: A UK Brain Bank Case–Control Study

open access: yesAnnals of Neurology, EarlyView.
Objective Despite diagnostic criteria refinements, Parkinson's disease (PD) clinical diagnosis still suffers from a not satisfying accuracy, with the post‐mortem examination as the gold standard for diagnosis. Seminal clinicopathological series highlighted that a relevant number of patients alive‐diagnosed with idiopathic PD have an alternative post ...
Lazzaro di Biase   +2 more
wiley   +1 more source

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