Results 241 to 250 of about 354,424 (374)

Frequency and Early Predictors of Cognitive Deterioration in Amyotrophic Lateral Sclerosis: A Longitudinal Population‐Based Study

open access: yesAnnals of Neurology, EarlyView.
Objective The objective is to evaluate cognitive and behavioral progression and identify early predictors of these changes in a cohort of amyotrophic lateral sclerosis (ALS) patients. Methods A total of 161 ALS patients were tested at diagnosis (T0), and 107 were re‐tested after 1 year (T1) using cognitive/behavioral tests. All patients underwent whole‐
Barbara Iazzolino   +13 more
wiley   +1 more source

New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain

open access: yesAngewandte Chemie, EarlyView.
We present a novel RNA aptamer targeting the transferrin receptor (TfR), conjugated with DSPE lipid, which achieves remarkably efficient brain uptake, reaching brain‐to‐serum ratios as high as 6.5. Through fluorescence imaging and polymerase‐chain reaction analyses, we verify that this new conjugate successfully delivers a substantial amount of DNA ...
Min‐sun Song   +8 more
wiley   +2 more sources

Regional Cerebral Atrophy Contributes to Personalized Survival Prediction in Amyotrophic Lateral Sclerosis: A Multicentre, Machine Learning, Deformation‐Based Morphometry Study

open access: yesAnnals of Neurology, EarlyView.
Objective Accurate personalized survival prediction in amyotrophic lateral sclerosis is essential for effective patient care planning. This study investigates whether grey and white matter changes measured by magnetic resonance imaging can improve individual survival predictions.
Isabelle Lajoie   +3 more
wiley   +1 more source

Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage

open access: yesEndocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Saturated fatty acids induce insulin resistance in neurons. Neuronal metabolism of palmitic acid alters mitochondrial function. Abstract Introduction Saturated fatty acids (FAs) are the main component of high‐fat diets (HFDs), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and ...
Karina Sánchez‐Alegría   +1 more
wiley   +1 more source

Brain Metabolic Features of FUS‐ALS: A 2‐[18F]FDG‐PET Study

open access: yesAnnals of Neurology, EarlyView.
Objective We aimed at evaluating the brain metabolic features of fused in sarcoma amyotrophic lateral sclerosis (FUS‐ALS) compared with sporadic ALS (sALS), using 2‐[fluorine‐18] fluoro‐2‐deoxy‐D‐glucose positron emission tomography (2‐[18F]FDG‐PET). Methods We employed the 2‐sample t‐test model of SPM12, implemented in MATLAB, to compare 12 FUS‐ALS ...
Antonio Canosa   +24 more
wiley   +1 more source

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