Results 31 to 40 of about 1,256,692 (266)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Tango for a dream: Narrative liminality and musical sensuality in Richard Linklater's Waking Life

Alphaville: Journal of Film and Screen Media, 2015
Richard Linklater’s Waking Life (2001) combines unapologetically cerebral content with a sensuous audiovisual style; fragmentariness in the narrative with an all-encompassing breadth of ideas.
Danijela Kulezic-Wilson
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Characterizing a new clinical phenotype: the co-existence of cerebral venous outflow and connective tissue disorders

Frontiers in Neurology
BackgroundThere is increasing recognition of connective tissue disorders and their influence on disease in the general population. A conserved clinical phenotype involving connective tissue disorders and idiopathic intracranial hypertension (IIH) and ...
Jackson P. Midtlien, Brian P. Curry, Emily Chang, Nicholas R. Kiritsis, Jennifer B. Aldridge, Kyle M. Fargen   +5 more
doaj   +1 more source

Intraarterial Transplantation of Mitochondria After Ischemic Stroke Reduces Cerebral Infarction

Stroke: Vascular and Interventional Neurology, 2023
Background Transplantation of autologous mitochondria into ischemic tissue may mitigate injury caused by ischemia and reperfusion. Methods Using murine stroke models of middle cerebral artery occlusion, we sought to evaluate feasibility of delivery of ...
Pedro Norat, Jennifer D. Sokolowski, Catherine M. Gorick, Sauson Soldozy, Jeyan S. Kumar, Youngrok Chae, Kaan Yagmurlu, Joelle Nilak, Khadijeh A. Sharifi, Melanie Walker, Michael R. Levitt, Alexander L. Klibanov, Zhen Yan, Richard J. Price, Petr Tvrdik, Mohammad Yashar S. Kalani   +15 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Brain proton magnetic resonance spectroscopy findings in a Beagle dog with genetically confirmed Lafora disease

Journal of Veterinary Internal Medicine, 2020
Cortical atrophy has been identified using magnetic resonance imaging (MRI) in humans and dogs with Lafora disease (LD). In humans, proton magnetic resonance spectroscopy (1HMRS) of the brain indicates decreased N‐acetyl‐aspartate (NAA) relative to other
Neringa Alisauskaite, Katrin Beckmann, Matthias Dennler, Niklaus Zölch   +3 more
doaj   +1 more source

Case report: Multiple brain intravascular papillary endothelial hyperplasia: incidence, diagnostic challenges, and management approach

Frontiers in Neurology, 2023
Multiple hemorrhagic brain lesions are mainly diagnosed based on clinico-radiological features integrated with histological data. Intravascular papillary endothelial hyperplasia (IPEH), or Masson's tumor, is a very rare entity, particularly when ...
Elena Anghileri, Bianca Pollo, Paolo Ferroli, Domenico Aquino, Greta Demichelis, Marco Schiariti, Francesco Ferrau, Luisa Chiapparini, Valeria Cuccarini   +8 more
doaj   +1 more source

CEREBRAL ABSCESS. [PDF]

Journal of the American Medical Association, 1908
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openaire   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source