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Cerebral activating properties of indeloxazine hydrochloride

Neuropharmacology, 1987
The cerebral-activating properties of indeloxazine hydrochloride [(+/-)-2-[(inden-7-yloxy) methyl]morpholine hydrochloride, YM-08054] were examined in comparison with those of calcium hopantenate (a cerebral metabolic enhancer), dihydroergotoxine (a cerebral vasodilator), viloxazine and amitriptyline (antidepressants).
M, Yamamoto, M, Shimizu
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Active Cerebral Perfusion during Carotid Endarterectomy

Asian Cardiovascular and Thoracic Annals, 2006
A patient with critical stenoses in the bilateral internal carotid arteries (ICA) required multivessel coronary revascularization. The diameter of the left ICA was far greater than the right, which strongly suggested that the cerebral circulation was highly dependent on the left.
Kazuhito, Imanaka   +3 more
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Activation and Inhibition of Cerebral Prolidase

Journal of Neurochemistry, 1980
AbstractPurification of prolidase from calf brain (acetone and [NH4]2SO4 fractionation) separated this enzyme from proteases, leucine aminopeptidase, master dipeptidase, and Gly‐Gly dipeptidase. Prolidase was tested with peptidase and protease inhibitors, used at higher levels (35 times or more) than their ID50 for peptidases and proteases. Bacitracin,
K S, Hui, A, Lajtha
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Cerebral activating drugs

1980
The term ‘cerebral activating drugs’ is used for the title of this chapter as a convenient way to embrace a wide variety of drugs which have been used in attempts to improve cerebral function in old age. Such drugs include vasodilators, drugs influencing cerebral metabolism, stimulants and drugs which are claimed to improve the flow of blood in the ...
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Cerebral vasodilators potentiate the anti-anoxic activity of indeloxazine hydrochloride, a new cerebral activator

Neuropharmacology, 1989
Effects of some cerebrovasodilators on the anti-anoxic activity of indeloxazine hydrochloride [(+/-)-2[(inden-7-yloxy)methyl]morpholine hydrochloride, YM-08054] with cerebral metabolic enhancing activity, were observed in mice. Oral administration of both indeloxazine (10 mg/kg) and each of the cerebral vasodilators, such as nicardipine (10 mg/kg ...
M, Yamamoto, M, Shimizu, S, Kawabata
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Cerebral Metabolism and Visualization of Cerebral Activity

1996
The biochemical pathways of energy metabolism in the brain are in most respects the same as those in other tissues, but special conditions peculiar to the central nervous system in vivo limit their full expression. For example, in many tissues the results of in vitro experiments are almost directly transferable to in vivo conditions, and, indeed, in ...
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Fuelling Cerebral Activity in Exercising Man

Journal of Cerebral Blood Flow & Metabolism, 2006
The metabolic response to brain activation in exercise might be expressed as the cerebral metabolic ratio (MR; uptake O2/glucose + 1/2 lactate). At rest, brain energy is provided by a balanced oxidation of glucose as MR is close to 6, but activation provokes a ‘surplus’ uptake of glucose relative to that of O2.
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Cerebral Activity and Consciousness

1974
By consciousness I mean conscious experience, which each of us has privately for himself. It is the primary reality for each of us, as I have argued in my book (Eccles, 1970). I try to avoid the words ‘mind’ and ‘mental’ because they have been so indiscriminately misused that they now are devoid of precise meaning.
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Plasminogen Activator and Cerebral Infarction

Annals of Internal Medicine, 1988
Excerpt To THE EDITOR: In four series evaluating recombinant tissue plasminogen activator (rTPA) treatment in acute myocardial infarction, no major events of the central nervous system were reporte...
ROBERT E. CRANSTON   +4 more
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Aldehyde dehydrogenase activity in rat cerebral structures

Neuroscience and Behavioral Physiology, 1990
By means of the quantitative histochemical method aldehyde dehydrogenase (AldDG; acidic phosphatase 1.2.1.3.) activity has been studied in neuronal structures of all parts of the rat CNS. The greatest activity has been revealed in cytoplasm of receptor (nucleus of the mesencephalic tract trigeminal nerve-1,100 stipulated units) and effector (all motor ...
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