Results 41 to 50 of about 632,936 (267)

Inter- and intra-individual variation in brain structural-cognition relationships in aging

NeuroImage, 2022
The sources of inter- and intra-individual variability in age-related cognitive decline remain poorly understood. We examined the association between 20-year trajectories of cognitive decline and multimodal brain structure and morphology in older age. We
Raihaan Patel, Clare E. Mackay, Michelle G. Jansen, Gabriel A. Devenyi, M. Clare O'Donoghue, Mika Kivimäki, Archana Singh-Manoux, Enikő Zsoldos, Klaus P. Ebmeier, M. Mallar Chakravarty, Sana Suri   +10 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Cerebrocortical beta activity in overweight humans responds to insulin detemir.

PLoS ONE, 2007
BackgroundInsulin stimulates cerebrocortical beta and theta activity in lean humans. This effect is reduced in obese individuals indicating cerebrocortical insulin resistance.
Otto Tschritter, Anita M Hennige, Hubert Preissl, Katarina Porubska, Silke A Schäfer, Werner Lutzenberger, Fausto Machicao, Niels Birbaumer, Andreas Fritsche, Hans-Ulrich Häring   +9 more
doaj   +1 more source

Describing Effectiveness of Performing International Classification of Function, Disability and Health on Children with Cerebral Palsy

Bezmiâlem Science, 2023
Objective:Aim of this study was to investigate the effectiveness of performing the International classification of functioning, disability and health: children and youth version (ICF-CY) on the description of functioning, disability and health in ...
Ahmed Hamood AL SAKKAF, Uğur CAVLAK, Erdoğan KAVLAK   +2 more
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Sympathetic nerve block as an add-on therapy for intervention and prevention of cerebral vasospasm after subarachnoid hemorrhage

Frontiers in Neurology
Cerebral vasospasm is a major complication after subarachnoid hemorrhage (SAH) and is an important factor leading to disability and mortality in patients.
Zhaoquan Wang, Jianqiang Li
doaj   +1 more source

Parkin-Dependent Mitophagy Is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats

Cells, 2019
Background: Nod-like receptor protein 3 (NLRP3) inflammasome is a crucial contributor in the inflammatory process during cerebral ischemia/reperfusion (I/R) injury.
Qi He, Zhenyu Li, Changchang Meng, Jingxian Wu, Yong Zhao, Jing Zhao   +5 more
doaj   +1 more source

Developmental defects and impaired network excitability in a cerebral organoid model of KCNJ11 p.V59M-related neonatal diabetes

Scientific Reports, 2021
The gene KCNJ11 encodes Kir6.2 a major subunit of the ATP-sensitive potassium channel (KATP) expressed in both the pancreas and brain. Heterozygous gain of function mutations in KCNJ11 can cause neonatal diabetes mellitus (NDM).
Gokhan Dalgin, Andrew K. Tryba, Ashley P. Cohen, Soo-Young Park, Louis H. Philipson, Siri Atma W. Greeley, Alfredo J. Garcia   +6 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Amyloid-β peptide absence in short term effects on kinase activity of energy metabolism in mice hippocampus and cerebral cortex

Anais da Academia Brasileira de Ciências, 2016
Considering that Alzheimer's disease is a prevalent neurodegenerative disease worldwide, we investigated the activities of three key kinases: creatine kinase, pyruvate kinase and adenylate kinase in the hippocampus and cerebral cortex in Alzheimer's ...
FRANCINE R. IANISKI, VIRGINIA C. RECH, VIVIAN S.K. NISHIHIRA, CATIANE B. ALVES, MATHEUS D. BALDISSERA, ETHEL A. WILHELM, CRISTIANE LUCHESE   +6 more
doaj   +1 more source