Results 61 to 70 of about 6,798,168 (311)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

THE PECULIARITIES OF CEREBRAL BLOOD FLOW IN PATIENTS WITH CHRONIC HEPATITIS

Рациональная фармакотерапия в кардиологии, 2015
Aim. To study extra- and intracranial hemodynamics in patients with chronic hepatitis of different activity.Material and methods. Ultrasonography of the cerebral blood flow was performed in 576 patients with chronic hepatitis.Results.
V. E. Kulikov, B. B. Fishman, A. V. Volkov, G. S. Malyutin, G. I. Shvartsman   +4 more
doaj   +1 more source

Cerebral oxygenation and bioelectrical activity in preterm infants during surfactant replacement therapy with porcine and bovine preparations

Archives of Medical Science, 2020
Introduction Surfactant replacement therapy (SRT) might cause acute changes in cerebral oxygenation and alteration of brain bioelectrical activity. Varying physiologic responses and clinical outcomes were observed when different surfactant preparations ...
Tomasz Szczapa, Łukasz Karpiński, Hanna Szczapa-Krenz, Beata Witosław, Aleksandra Adamczak, Jerzy Moczko, Izabela Miechowicz, Paweł Niedbalski, Marta Szymankiewicz-Bręborowicz, Jan Mazela   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Inter- and intra-individual variation in brain structural-cognition relationships in aging

NeuroImage, 2022
The sources of inter- and intra-individual variability in age-related cognitive decline remain poorly understood. We examined the association between 20-year trajectories of cognitive decline and multimodal brain structure and morphology in older age. We
Raihaan Patel, Clare E. Mackay, Michelle G. Jansen, Gabriel A. Devenyi, M. Clare O'Donoghue, Mika Kivimäki, Archana Singh-Manoux, Enikő Zsoldos, Klaus P. Ebmeier, M. Mallar Chakravarty, Sana Suri   +10 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Describing Effectiveness of Performing International Classification of Function, Disability and Health on Children with Cerebral Palsy

Bezmiâlem Science, 2023
Objective:Aim of this study was to investigate the effectiveness of performing the International classification of functioning, disability and health: children and youth version (ICF-CY) on the description of functioning, disability and health in ...
Ahmed Hamood AL SAKKAF, Uğur CAVLAK, Erdoğan KAVLAK   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Cerebrocortical beta activity in overweight humans responds to insulin detemir.

PLoS ONE, 2007
BackgroundInsulin stimulates cerebrocortical beta and theta activity in lean humans. This effect is reduced in obese individuals indicating cerebrocortical insulin resistance.
Otto Tschritter, Anita M Hennige, Hubert Preissl, Katarina Porubska, Silke A Schäfer, Werner Lutzenberger, Fausto Machicao, Niels Birbaumer, Andreas Fritsche, Hans-Ulrich Häring   +9 more
doaj   +1 more source