Results 71 to 80 of about 7,097,396 (308)

Amyloid-β peptide absence in short term effects on kinase activity of energy metabolism in mice hippocampus and cerebral cortex

Anais da Academia Brasileira de Ciências, 2016
Considering that Alzheimer's disease is a prevalent neurodegenerative disease worldwide, we investigated the activities of three key kinases: creatine kinase, pyruvate kinase and adenylate kinase in the hippocampus and cerebral cortex in Alzheimer's ...
FRANCINE R. IANISKI, VIRGINIA C. RECH, VIVIAN S.K. NISHIHIRA, CATIANE B. ALVES, MATHEUS D. BALDISSERA, ETHEL A. WILHELM, CRISTIANE LUCHESE   +6 more
doaj   +1 more source

Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease. [PDF]

, 2009
Cerebral malaria is a life-threatening complication of malaria infection. The pathogenesis of cerebral malaria is poorly defined and progress in understanding the condition is severely hampered by the inability to study in detail, ante-mortem, the ...
KEVIN N. COUPER, Couper, Kevin N, Riley, Eleanor M, Hafalla, Julius CR, Brian De Souza, J., Hafalla, Julius C R, Couper, Kevin N., JULIUS C. R. HAFALLA, de Souza, J Brian, Riley, Eleanor M., ELEANOR M. RILEY, J. BRIAN de SOUZA   +11 more
core   +1 more source

Antioxidant Activity of Grapevine Leaf Extracts against Oxidative Stress Induced by Carbon Tetrachloride in Cerebral Cortex, Hippocampus and Cerebellum of Rats

Antioxidants, 2014
In recent years, it has become increasingly important to study the beneficial properties of derivatives of grapes and grapevine. The objective of this study was to determine the antioxidant activity of Vitis labrusca leaf extracts, comparing conventional
Mariane Wohlenberg, Daniela Almeida, Liane Bokowski, Niara Medeiros, Fabiana Agostini, Cláudia Funchal, Caroline Dani   +6 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Guía de orientación para familiares, amistades y personas que ejercen los cuidados de personas con daño cerebral adquirido [PDF]

Esta guía está dirigida a familiares, amigos y cuidadores de personas con daño cerebral. El texto ofrece indicaciones sencillas sobre las diferentes etapas en la evolución del daño cerebral desde los primeros momentos de la lesión y pretende servir de ...
Daño Cerebral Estatal
core  

Multivitamins and minerals modulate whole-body energy metabolism and cerebral blood-flow during cognitive task performance: a double-blind, randomised, placebo-controlled trial [PDF]

, 2016
Background: The brain is by far the most metabolically active organ in the body, with overall energy expenditure and local blood-supply closely related to neural activity.
Jackson, Philippa A., Sarah Dunn (3444305), Dunn, Sarah, Philippa Jackson (3444317), Philippa A. Jackson, Jackson, Philippa, Karl Wishart, Fiona L. Dodd, Gregor Bieri (3444302), Alexandra Carne (3444308), David O. Kennedy, Crystal F. Haskell-Ramsay, Stevenson, Emma J., Wishart, Karl, Emma J. Stevenson, Emma Stevenson (649191), Forster, Joanne, Fiona Dodd (3444311), Crystal Haskell-Ramsay (3444314), Sarah Dunn, Haskell, Crystal, Stevenson, Emma, Dodd, Fiona, Kennedy, David O., David Kennedy (91996), Kennedy, David, Luca Barella, Karl Wishart (2299858), Dodd, Fiona L., Luca Barella (3444299), Bieri, Gregor, Robertson, Bernadette, Haskell-Ramsay, Crystal F., Bernadette C. Robertson, Joanne Forster, Carne, Alexandra, Bernadette Robertson (3444323), Gregor Bieri, Barella, Luca, Alexandra Carne, Robertson, Bernadette C., Joanne Forster (3444320)   +41 more
core   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source