Results 101 to 110 of about 164,310 (312)

Membrane Lipid-KIR2.x Channel Interactions Enable Hemodynamic Sensing in Cerebral Arteries

, 2019
Objective- Inward rectifying K+ (KIR) channels are present in cerebral arterial smooth muscle and endothelial cells, a tandem arrangement suggestive of a dynamic yet undiscovered role for this channel.
Hald, Bjorn O, Hald, Bjorn O., Poepping, Tamie L, Sandow, Shaun L., Sancho, Maria, Sandow, S. L., Poepping, T. L., Sandow, Shaun L, Sancho, M., Hald, Bjørn O., Sancho González, María, Welsh, Donald G., Hald, B. O., Fabris, Sergio, Fabris, S., Brett, Suzanne E., Welsh, D. G., Welsh, Donald G, Poepping, Tamie L., Brett, Suzanne E   +19 more
core   +1 more source

Optimization of Magnetic Milli‐Spinner for Robotic Endovascular Intervention

Advanced Robotics Research, EarlyView.
This work presents the design optimization of a multifunctional magnetic milli‐spinner for high‐speed propulsion and efficient clot debulking. The optimized design achieves an ultrafast swimming velocity of 55 cm/s (≈175 body lengths/s) in saline water, enabling stable upstream swimming against strong physiological flows and establishing magnetic milli‐
Lu Lu, Luca Higgins, Jack Bernardo, Ruike Renee Zhao   +3 more
wiley   +1 more source

Effect of Phenylephrine on Cerebrovascular Regulation: A Translational Perspective

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Phenylephrine is an alpha 1‐adrenergic receptor (α1R) agonist. Evidence indicates activation of α1Rs can initiate both vasoconstrictor and dilator signaling. How phenylephrine affects cerebrovascular regulation remains unclear.
Adam M. S. Luchkanych, Breanna Barlage, Gabriela Delgado, Jude S. Morton, Cameron J. Morse, Erika M. Boerman, Ryan L. Hoiland, Mypinder S. Sekhon, Michael M. Tymko, Jaume Padilla, Craig A. Emter, Corey R. Tomczak, M. Harold Laughlin, T. Dylan Olver   +13 more
doaj   +1 more source

THE PECULIARITIES OF CEREBRAL BLOOD FLOW IN PATIENTS WITH CHRONIC HEPATITIS

Рациональная фармакотерапия в кардиологии, 2015
Aim. To study extra- and intracranial hemodynamics in patients with chronic hepatitis of different activity.Material and methods. Ultrasonography of the cerebral blood flow was performed in 576 patients with chronic hepatitis.Results.
V. E. Kulikov, B. B. Fishman, A. V. Volkov, G. S. Malyutin, G. I. Shvartsman   +4 more
doaj   +1 more source

P2X purinoceptors in postmortem human cerebral arteries

, 1998
Pharmacological studies have demonstrated that various purinoceptors are involved in the control of the cerebral vascular tone in many species. In this study, the existence of P2X purinoceptors in the postmortem human cerebral arteries was investigated ...
Burnstock G., Nori SL, Bo X, Bardini M, Karoon P   +4 more
core   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Potassium channel activators protect the N-methyl-D-aspartate-induced cerebral vascular dilation after combined hypoxia and ischemia in piglets

, 1998
Background and Purpose-Cerebral arteriolar dilation to N-methyl-D-aspartate (NMDA) is a neuronally mediated multistep process that is sensitive to cerebral hypoxia and ischemia (H/I).
Domoki, Ferenc, Bari, Ferenc, Veltkamp, R.   +2 more
core  

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

The influence of occlusive-stenotic lesions of the arteries of the head and neck on the methods and results of surgical treatment of ruptured arterial aneurysms

Сучасні медичні технології
Aim: to analyze the results of surgical treatment of patients with ruptured arterial aneurysms in the presence of occlusive-stenotic lesions of cerebral arteries and to evaluate the impact of combined lesions on the choice of surgical treatment method.
V. P. Komarnytskyi, M. Yu. Orlov, O. Yu. Polkovnikov, O. Ye. Skobska, M. V. Yelieinyk   +4 more
doaj   +1 more source

MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid haemorrhage in rats.

PLoS ONE, 2019
Vascular pathophysiological changes after haemorrhagic stroke, such as phenotypic modulation of the cerebral arteries and cerebral vasospasms, are associated with delayed cerebral ischemia (DCI) and poor outcome.
Simon T Christensen, Sara E Johansson, Aneta Radziwon-Balicka, Karin Warfvinge, Kristian A Haanes, Lars Edvinsson   +5 more
doaj   +1 more source