Results 241 to 250 of about 229,592 (307)

Effects of descending aortic occlusion for massive obstetric hemorrhage: Nationwide analysis of maternal death in Japan

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate the effects of aortic occlusion (AO) on severe postpartum hemorrhage (PPH)—a leading cause of preventable maternal mortality—using a nationwide maternal death registry in Japan. Methods A nationwide retrospective observational study of hemorrhage‐related maternal deaths was conducted in Japan between 2010 and 2024 ...
Makoto Aoki, Soichiro Obata, Manabu Ogoyama, Koki Shimura, Yutaka Iwagoi, Makiko Kasahara, Yui Yoshida, Saya Yamashita, Akihiko Sekizawa, Koji Hashii, Masahiko Nakata, Takeshi Murakoshi, Shinji Katsuragi, Hiroaki Tanaka, Kayo Tanaka, Yoko Sagara, Tatsuya Arakaki, Junichi Hasegawa, on behalf of the Working group of Maternal Mortality 2025 in the Japan Association of Obstetricians and Gynecologists   +18 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

iNew Medicine, EarlyView.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang, Yinbo Xu, Yiting Zhao, Liuyi Li, Zhengyi Cheng, Zhongqi Zhang, Yuhang Luo, Qiaoling Liu, Chen Gong, Shichun Shen   +9 more
wiley   +1 more source

Advanced age and female sex protect cerebral arteries from mitochondrial depolarization and apoptosis during acute oxidative stress. [PDF]

Aging Cell
Norton CE, Shaw RL, Safa, Dockery B, Domeier TL, Segal SS.   +5 more
europepmc   +1 more source

Macrophage extracellular vesicles deliver Mef2d proteins to aggravate Bacteroides fragilis pathogenicity in type 2 diabetes arterial calcification

Interdisciplinary Medicine, EarlyView.
Bacteroides fragilis is associated with type 2 diabetes (T2D) arterial calcification and can be activated by macrophage‐derived extracellular vesicles (EVs). BF takes up EVs via receptor‐mediated endocytosis, and activation is induced by EV‐derived Mef2d, thereby inhibiting ArsR family transcriptional regulator transcription.
Cong Chen, Rong He, Jirong Luo, Zhengfeng Liang, Qunwen Pan, Shuangquan Liu, Jingsong Cao   +6 more
wiley   +1 more source

Paternal preconception alcohol consumption increased Angiotensin II-mediated vasoconstriction in male offspring cerebral arteries via oxidative stress-AT1R pathway. [PDF]

Addict Biol
Zhang Z, Zhang Y, Liu M, Su H, He Y, Zheng Q, Xu Z, Tang J.   +7 more
europepmc   +1 more source

A Comparative Study of Transcranial Color-Coded Doppler (TCCD) and Transcranial Doppler (TCD) Ultrasonography Techniques in Assessing the Intracranial Cerebral Arteries Haemodynamics. [PDF]

Diagnostics (Basel)
Gunda ST, Ng TKV, Liu TY, Chen Z, Han X, Chen X, Pang MY, Ying MT.   +7 more
europepmc   +1 more source

Impact of knockout of dual-specificity protein phosphatase 5 on structural and mechanical properties of rat middle cerebral arteries: implications for vascular aging. [PDF]

Geroscience
Tang C, Zhang H, Border JJ, Liu Y, Fang X, Jefferson JR, Gregory A, Johnson C, Lee TJ, Bai S, Sharma A, Shin SM, Yu H, Roman RJ, Fan F.   +14 more
europepmc   +1 more source