Results 61 to 70 of about 229,592 (307)

Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats [PDF]

, 2017
This protocol describes the use of in vitro television microscopy to evaluate vascular function in isolated cerebral resistance arteries (and other vessels), and describes techniques for evaluating tissue perfusion using Laser Doppler Flowmetry (LDF) and
Allen, L. Adrienne, Durand, Matthew J., Geurts, Aron M., Lombard, Julian H., Lukaszewicz, Kathleen M., Priestley, Jessica R. C., Schmidt, James R.   +6 more
core   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Lack of effect of pravastatin on cerebral blood flow or parenchymal volume loss in elderly at risk for vascular disease [PDF]

, 2005
<p><b>Background and Purpose:</b> Ageing is associated with a decline in cerebral blood flow. Animal studies have shown that cholesterol-lowering therapy with statins might preserve cerebral blood flow (CBF).
Blauw, G.J., Bollen, E.L.E.M., Box, F.M.A., de Craen, A.J.M., Murray, H.M., ten Dam, V.H., van Buchem, M.A., van den Heuvel, D.M.J., Westendorp, R.G.J.   +8 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Management considerations of massive hemoptysis while on extracorporeal membrane oxygenation. [PDF]

, 2016
BACKGROUND: Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is a life-saving procedure in patients with both respiratory and cardiac failure. Bleeding complications are common since patients must be maintained on anticoagulation.
Cavarocchi, Nicholas C., Cowan, Scott W., Harrison, Meredith A., Hirose, Hitoshi, Pitcher, Harrsion T., Shaw, Colette   +5 more
core   +2 more sources

Kv2.1 channels play opposing roles in regulating membrane potential, Ca2+ channel function, and myogenic tone in arterial smooth muscle. [PDF]

, 2020
The accepted role of the protein Kv2.1 in arterial smooth muscle cells is to form K+ channels in the sarcolemma. Opening of Kv2.1 channels causes membrane hyperpolarization, which decreases the activity of L-type CaV1.2 channels, lowering intracellular ...
Guarina, Laura, Klug, Nicholas R, Matsumoto, Collin, McKinnon, David, O'Dwyer, Samantha C, Palacio, Stephanie, Rosati, Barbara, Santana, L Fernando, Tajada, Sendoa, Trimmer, James S   +9 more
core   +3 more sources

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source

Sex differences in cerebral pulsatility and damping: A 4D flow MRI study

Experimental Physiology
Cerebral pulsatility is a potential marker of cerebrovascular health, yet little is understood about sex differences in cerebral pulsatility with age, especially within different cerebral arteries.
Sarean Harmoni A. Gaynor‐Metzinger, Alexander M. Norby, Brandon G. Fico, M. Erin Moir, Nicole A. Loggie, Kathleen B. Miller, Adam T. Corkery, Andrew G. Pearson, Anna J. Howery, Leonardo A. Rivera‐Rivera, Kevin M. Johnson, Sterling C. Johnson, Oliver Wieben, Ryan D. Zea, Jill N. Barnes   +14 more
doaj   +1 more source

Peripheral and Cerebral Resistance Arteries in the Spontaneously Hypertensive Heart Failure Rat: Effects of Stilbenoid Polyphenols

Molecules, 2017
Hypertension is associated with aberrant structure and mechanical properties of resistance arteries. We determined the effects of resveratrol, a non-flavonoid polyphenol found in foods such as red grapes, and structurally-similar analogues (pterostilbene
Danielle I. Lee, Crystal Acosta, Christopher M. Anderson, Hope D. Anderson   +3 more
doaj   +1 more source

Large conductance Ca2+-activated K+ channel (BKCa) α-subunit splice variants in resistance arteries from rat cerebral and skeletal muscle vasculature. [PDF]

PLoS ONE, 2014
Previous studies report functional differences in large conductance Ca2+ activated-K+ channels (BKCa) of smooth muscle cells (VSMC) from rat cerebral and cremaster muscle resistance arteries.
Zahra Nourian, Min Li, M Dennis Leo, Jonathan H Jaggar, Andrew P Braun, Michael A Hill   +5 more
doaj   +1 more source