Results 41 to 50 of about 17,546 (218)

Losing the dogmatic view of cerebral autoregulation

Physiological Reports, 2021
In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic review article entitled Cerebral Blood Flow and Oxygen Consumption in Man.
Patrice Brassard, Lawrence Labrecque, Jonathan D. Smirl, Michael M. Tymko, Hannah G. Caldwell, Ryan L. Hoiland, Samuel J. E. Lucas, André Y. Denault, Etienne J. Couture, Philip N. Ainslie   +9 more
doaj   +1 more source

Effects of desflurane on cerebral autoregulation [PDF]

British Journal of Anaesthesia, 2001
The aim of this study was to determine the effects of desflurane, at 1 and 1.5 MAC, on cerebral autoregulation. Data were analysed from eight patients undergoing non-neurosurgical procedure. The blood flow velocity in the middle cerebral artery was measured by transcranial Doppler ultrasound and cerebral autoregulation was assessed by the transient ...
N M, Bedforth, K J, Girling, H J, Skinner, R P, Mahajan   +3 more
openaire   +2 more sources

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Calibration‐Free Estimation of Cerebrovascular Reactivity From Resting‐State BOLD fMRI Using Reconstructed Respiratory Fluctuations

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Cerebrovascular reactivity (CVR) provides an important index of vascular health and is conventionally quantified using a hypercapnic gas or breath‐hold challenge in conjunction with blood‐oxygen‐level‐dependent functional magnetic resonance imaging (BOLD‐fMRI).
Abdoljalil Addeh, Ethan Church, Muhammad Mahajna, Karen Ardila, Pattarawut Charatpangoon, Alexander D. Cohen, Yang Wang, Rebecca J. Williams, G. Bruce Pike, M. Ethan MacDonald   +9 more
wiley   +1 more source

Impaired Dynamic Cerebral Autoregulation in Cerebral Venous Thrombosis

Frontiers in Neurology, 2020
Background: Cerebral autoregulation is crucial in traumatic brain injury, which might be used for determining the optimal intracranial pressure. Cerebral venous thrombosis (CVT) is a cerebral vascular disease with features of high intracranial pressure ...
Jie Chen, Jia Liu, Kehui Dong, Yilong Wang, Xingquan Zhao, Yongjun Wang, Xiping Gong   +6 more
doaj   +1 more source

Neuroimaging Findings and Risk Factors for Brain Injury in Foetuses Treated for Anaemia

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Characterize neuroimaging findings in foetuses with anaemia and identify associated risk factors. Methods Retrospective cohort study of pregnancies with foetal anaemia (defined as haemoglobin > 2 standard deviations below the gestational age mean) confirmed by foetal blood sampling (FBS) and treated with intrauterine transfusion (IUT)
Laurence Sophie Carmant, Carlos Robles, Seungwoo Lee, Prakesh S. Shah, Greg Ryan, Elka Miller, Shiri Shinar   +6 more
wiley   +1 more source

METHOD FOR DETERMINING THE UPPER LIMIT OF CEREBRAL AUTOREGULATION IN RATS

Фармация и фармакология (Пятигорск), 2018
The main objective of the phenomenon of cerebral autoregulation is to maintain a constant cerebral blood flow rate with changes in systemic arterial pressure in the range of 50 mmH up to 150 Mmhg.
A. V. Voronkov, A. S. Lysenko
doaj   +1 more source

Validation of Aortic Blood Flow Simulations During Extracorporeal Circulation Using Phase Contrast Magnetic Resonance Imaging

Artificial Organs, EarlyView.
This is the first study assessing in vivo blood flow profiles during extracorporeal circulation (ECC) scenarios. Magnetic resonance imaging data served for the calibration of computational fluid dynamics algorithms, enabling accurate replication of the hemodynamic conditions.
Anna Kathrin Assmann, Sinje Reimers, Jonah S. Schrauder, Lei Qu, Xiangge Yin, Amir Moussavi, Artur Lichtenberg, Susann Boretius, Michael Neidlin, Alexander Assmann   +9 more
wiley   +1 more source

Increased impairment of cerebral autoregulation in COVID-19 associated pulmonary failure requiring extracorporeal membrane oxygenation

Frontiers in Medicine
IntroductionCerebrovascular complications are feared but also commonly reported in patients with COVID-19 requiring extracorporeal membrane oxygenation (ECMO) support therapy.
Marcus Thudium, Jochen Kappler, Maximilian J. G. Oremek, Stefan Felix Ehrentraut, Evgeniya Kornilov, Milka Marinova, Christian Putensen, Martin Soehle, Jens-Christian Schewe, Jens-Christian Schewe   +9 more
doaj   +1 more source