Results 141 to 150 of about 1,173,497 (381)

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39

Nature Communications
Microglia and the border-associated macrophages contribute to the modulation of cerebral blood flow, but the mechanisms have remained uncertain.
Zhongxiao Fu, Mallikarjunarao Ganesana, Philip Hwang, Xiao Tan, Melissa Marie Kinkaid, Yu-Yo Sun, Emily Bian, Aden Weybright, Hong-Ru Chen, Katia Sol-Church, Ukpong B. Eyo, Clare Pridans, Francisco J. Quintana, Simon C. Robson, Pankaj Kumar, B. Jill Venton, Anne Schaefer, Chia-Yi Kuan   +17 more
doaj   +1 more source

Cerebral blood flow characteristics following hemodialysis initiation in older adults: A prospective longitudinal pilot study using arterial spin labeling imaging

, 2020
Xiufeng Li, Yelena Slinin, Lin Zhang, Donald R. Dengel, David E. Tupper, Gregory J. Metzger, Anne M. Murray   +6 more
openalex   +1 more source

20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility

, 2021
Yedan Liu, Huawei Zhang, Celeste YC. Wu, Tina Yu, Xing Fang, Jane J Ryu, Baoying Zheng, Zongbo Chen, Richard J. Roman, Fan Fan   +9 more
openalex   +2 more sources

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Capillary pericytes regulate cerebral blood flow in health and disease

Nature, 2014
C. Hall, C. Reynell, Bodil Gesslein, N. Hamilton, Anusha Mishra, B. Sutherland, F. O'Farrell, A. Buchan, M. Lauritzen, D. Attwell   +9 more
semanticscholar   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

A System for Cerebral Blood Flow Measurement Using an H₂¹⁵O Autoradiographic Method and Positron Emission Tomography [PDF]

, 1987
Iwao Kanno, Hidehiro Iida, Shuichi Miura, M.T. Murakami, Kazuhiro Takahashi, Hiroshi Sasaki, A Inugami, F Shishido, Kazuki Uemura   +8 more
openalex   +1 more source

Treatment evaluation of Kami Guibi‐tang on participants with amnestic mild cognitive impairment using magnetic resonance imaging on brain metabolites, gamma‐aminobutyric acid, and cerebral blood flow

, 2021
Seung‐Yeon Cho, Sharonkyuhee Kwon, Hee-yeon Shin, Ha-ri Kim, Jeong‐Hwa Kim, Soonchan Park, Chang‐Woo Ryu, Jung‐Mi Park, Richard A.E. Edden, Geon‐Ho Jahng   +9 more
openalex   +1 more source