Results 151 to 160 of about 1,173,497 (381)

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Nature Reviews Neuroscience, 2017
Kassandra Kisler, Amy R. Nelson, Axel Montagne, B. Zlokovic   +3 more
semanticscholar   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Cerebral Blood Flow in Mild Cognitive Impairment and Dementia: A Systematic Review and Meta- Analysis of Transcranial Doppler Studies

Cerebral Circulation - Cognition and Behavior
Introduction: Reduced cerebral blood flow has been associated with cognitive decline and incident dementia, with oxidative stress and reduced beta-amyloid clearance as possible mechanisms for neurodegeneration.
David Fresnais, Håkon Ihle-Hansen, Åsa Andersson, Erik Lundström, Brynjar Fure   +4 more
doaj   +1 more source

Cerebral Vasoreactivity During Acute and Recovery Phase Post-Concussion: A Pilot Study [PDF]

, 2016
The diagnosis of sports-related concussion is based mostly on clinical symptoms. Return-to-play decisions are made when the athletes are symptom free; however, some metabolic and physiological impairments may persist such as impairments in cerebral blood
Davis, Peter F, Maffuid, Kaitlyn, Murphy, Megan N, Purkayastha, Sushmita   +3 more
core   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Reduced cerebral blood flow in an α-synuclein transgenic mouse model of Parkinson’s disease [PDF]

, 2019
KC Biju, Qiang Shen, Enrique Torres Hernandez, Michael Mader, Robert A. Clark   +4 more
openalex   +1 more source

Regional Cerebral Blood Flow Changes in Healthy Ageing and Alzheimer’s Disease: A Narrative Review [PDF]

, 2022
Barnaby J. Graff, Stephanie L. Harrison, Stephen J. Payne, Wahbi K. El‐Bouri   +3 more
openalex   +1 more source

Perfusion-weighted magnetic resonance imaging of the brain: techniques and application in children [PDF]

, 2018
Perfusion-weighted magnetic resonance imaging (PWI) has been proposed as an attractive non-invasive tool for evaluating cerebral haemodynamics. Quantitative maps of cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to ...
Huisman, Thierry, Sorensen, A.
core  

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source