Results 161 to 170 of about 613,500 (197)

Cerebral Cavernous Malformations

New England Journal of Medicine, 1988
Daniele Rigamonti   +2 more
exaly   +6 more sources

Familial Cerebral Cavernous Malformations [PDF]

open access: yesStroke, 2019
Blaine Hart   +2 more
exaly   +3 more sources

Exceptional Aggressiveness of Cerebral Cavernous Malformation Disease Associated With PDCD10 Mutations [PDF]

open access: yesGenetics in Medicine, 2015
PurposeThe phenotypic manifestations of cerebral cavernous malformation disease caused by rare PDCD10 mutations have not been systematically examined, and a mechanistic link to Rho kinase-mediated hyperpermeability, a potential therapeutic target, has ...
Robert Shenkar, Murat Günel, Wang Min
exaly   +2 more sources

Pediatric Cerebral Cavernous Malformations

Pediatric Neurology, 2021
Cerebral cavernous malformations are the second most common vascular malformations in the central nervous system, and over one-third are found in children. Lesions may be solitary or multiple, be discovered incidentally, be sporadic, or be secondary to familial cavernomatosis or radiation therapy.
Michael Paddock   +4 more
openaire   +2 more sources

Cerebral Cavernous Malformations

New England Journal of Medicine, 2017
A 59-year-old man presented with a 1-year history of progressively worsening headaches. Imaging revealed multiple lesions, and genetic analysis confirmed a diagnosis of the familial cerebral cavernous malformation syndrome.
Ithamar, Ganmore, Anat, Achiron
openaire   +3 more sources

Evaluating Strategies for the Treatment of Cerebral Cavernous Malformations

open access: yesStroke, 2010
Cerebral cavernous malformations are common vascular lesions of the central nervous system that predispose to seizures, focal neurological deficits, and potentially fatal hemorrhagic stroke.
Kevin J Whitehead
exaly   +2 more sources

Genetics of cerebral cavernous malformations

Current Neurology and Neuroscience Reports, 2005
The past few years have seen rapid advances in our understanding of the genetics and molecular biology of cerebral cavernous malformations (CCM). This article summarizes the recent cloning of the CCM1, CCM2, and CCM3 genes, which are responsible for autosomal dominant CCM, and also describes current hypotheses for their roles in integrin and p38 ...
Nicholas W, Plummer   +2 more
openaire   +2 more sources

Cerebral cavernous malformations

Neurology, 2002
To find mutations in the recently identified additional exons of the Krit1 gene that causes CCM1, a disease characterized by the formation of cerebral cavernous malformations (CCM). To determine the relative frequency with which Krit1 mutations cause CCM as well as recharacterize the mutations reported in the literature.Twenty-seven families and 11 ...
D J, Verlaan   +5 more
openaire   +2 more sources

Cerebral Cavernous Malformations

Archives of Neurology, 1989
To the Editor. —In the February 1989 issue of theArchives, Allard et al 1 described several members of a family who had multiple lesions noted on magnetic resonance imaging that were termed arteriovenous malformations . These lesions, however, have the characteristic magnetic resonance imaging appearance of cavernous malformations (angiomas), another ...
K. S. Lee, R. F. Spetzler
openaire   +1 more source

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