Results 161 to 170 of about 7,738 (248)

Sympathetic Overactivation Drives Neurogenic Alveolar Epithelial Pyroptosis via the PIEZO2‐ER Stress Pathway in Acute Lung Injury Following Intracerebral Hemorrhage

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Following intracerebral hemorrhage, sympathetic overactivation drives acute lung injury via norepinephrine‐induced VPS35 upregulation. VPS35 promotes PIEZO2‐mediated calcium influx and impairs ATP2A2‐dependent ER calcium reuptake, triggering ER stress and NLRP3‐pyroptosis.
Shuai Han, Zirui Wang, Qiuyue Zheng, Feng Guo, Yinggang Xiao, Zi Wang, Tianfeng Huang, Yongxin Liang, Bingchun Yan, Ju Gao   +9 more
wiley   +1 more source

Beyond the Tipping Point: Advances in the Diagnosis and Management of Acute-on-Chronic Liver Failure and End-Stage Liver Disease. [PDF]

Diagnostics (Basel)
Soldera J.
europepmc   +1 more source

Admission Phenotype Clarifies the Apparent Prognostic Contrast Between TOAST Etiologic Subtypes in Large‐Core Anterior‐Circulation Large‐Vessel Occlusion

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
In large‐core anterior‐circulation LVO, the crude LAA–CE prognostic contrast was reduced by 96.2% after adjustment for measured admission phenotype in a model‐based decomposition. Adjusted EVT–outcome associations were similar across subtypes, arguing against modifying EVT selection solely by LAA versus CE etiology.
Chengsong Yue, Shihai Yang, Xiongxiong Hou, Jingfu Ma, Xu Xu, Xiaolei Shi, Linyu Li, Jie Yang, Changwei Guo, Jiaxing Song, Wenjie Zi, Rongzong Li   +11 more
wiley   +1 more source

Extracorporeal circulation management for stanford type a aortic dissection complicating pregnancy in a patient with marfan syndrome: a case report. [PDF]

J Cardiothorac Surg
Yang X, Kumar M, Jiang L, Shi H, Wang B.
europepmc   +1 more source

First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high‐quality data, expert consensus was additionally obtained through a modified Delphi process.
Giorgia Olivieri, Andrea Bordugo, Birute Burnyte, Alessandro Costetti, Maria‐Luz Couce, Luisa Diogo, Francois Feillet, D. Sean Froese, Benedetta Greco, Jean‐Louis Gueant, Luciana Hannibal, Friederike Hörster, Viktor Kožich, Giancarlo La Marca, Irini Manoli, Fanny Mochel, Lorenzo Orazi, Belén Pérez, Manuel Schiff, Bernd C. Schwahn, Ida Schwartz, Karolina M. Stepien, Jolanta Sykut‐Cegielska, Trine Tangeraas, Rolf H. Zetterström, Carlo Dionisi‐Vici, Martina Huemer   +26 more
wiley   +1 more source

Impact of Venoarterial Extracorporeal Membrane Oxygenation on Hemodynamics and Cardiac Mechanics: Insights From Pressure-Volume Loop Analysis. [PDF]

Int J Heart Fail
Otake M, Morita H, Sato K, Saku K.
europepmc   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Severe hypotension but not systemic inflammation or endothelial activation predicts encephalopathy in circulatory shock. [PDF]

Ann Intensive Care
Nguyen DN, Huyghens L, Nguyen TM, Schiettecatte J, Diltoer M, Cools W, De Cuyper H, Rhapsorski D, Smitz J, Zhang H.   +9 more
europepmc   +1 more source

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management

MedComm, Volume 7, Issue 7, July 2026.
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu, Xinyan Wu, Ting Yin, Feining Huang, Manqi Kong, Yu Yang, Zinan Liu, Jiabin Yu, Tianpeng Zhang   +8 more
wiley   +1 more source