Results 31 to 40 of about 7,738 (248)

Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal

Advanced Science, EarlyView.
We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao, Yi Hou, Jie Zhang, Bo Wang, Minghui Guo, Hua Qu, Wei Rao, Jing Liu   +7 more
wiley   +1 more source

Studies on Cerebral Circulatory Hemodynamics Using Radioiodinated Human Serum Albumin (RISA)

RADIOISOTOPES, 1964
すでにわれわれはRISA体外計測法を用い, 頭部血量と平均脳循環時間測定値より頭部血流量を算出し, その測定法および成績について報告した。頭部血量の測定誤差は現在ほぼ7.5%以内にとどめ得るが, Loveらも指摘するごとく平均脳循環時間については方法いかんにより誤差介入の余地が大きく, 脳血流量計算値に及ぼす意義が大きい。よって, 今回かかる点を検討し頭部および頸部より同時記録した血管放射図の対比より, 頸動脈→頸静脈球循環時間 (T) , 頸動脈→脳底動脈環循環時間 (ta) , 静脈洞連合→頸静脈循環時間 (tv) を求め, これらの値より平均脳循環時間 (t) を求めた。本法によりtは正常者で平均6.7秒で再現性にすぐれ, 脳血管障害例では延長が明らかであった。
ATARASHI, Jonosuke, YOSHIMURA, Masaharu, HARA, Kazuo, TERASHI, Akiro, MIYAZAKI, Tadashi, YAMATE, Masaji, IWASAKI, Hajime, KIKUCHI, Taro, YAMANO, Takashi   +8 more
openaire   +3 more sources

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Standards in neurosonology. Part II

Journal of Ultrasonography, 2016
The paper presents standards related to ultrasound imaging of the cerebral vasculature and structures. The aim of this paper is to standardize both the performance and description of ultrasound imaging of the extracranial and intracranial cerebral ...
Joanna Wojczal, Tomasz Tomczyk, Piotr Luchowski, Grzegorz Kozera, Radosław Kaźmierski, Zbigniew Stelmasiak   +5 more
doaj   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Standards in neurosonology. Part I

Journal of Ultrasonography, 2015
The paper presents standards related to ultrasound imaging of the cerebral vasculature and structures. The aim of this paper is to standardize both the performance and description of ultrasound imaging of the extracranial and intracranial cerebral ...
Joanna Wojcza, Tomasz Tomczyk, Piotr Luchowski, Grzegorz Kozera, Radosław Kaźmierski, Zbigniew Stelmasiak   +5 more
doaj   +1 more source

Circulatory Effect of Cigarette Smoking, with Special Reference to the Effect on Cerebral Hemodynamics

Japanese Circulation Journal, 1969
The circulatory effect of cigarette smoking on cerebral hemodynamics, blood pressure and pulse rate were investigated in four normal young men and eight elderly patients with mild diseases, all habitual tobacco smokers (10-20 cigarettes daily). (1) Decrease in cerebral vascular resistance (dilatation of cerebral blood vessel) and increase in cerebral ...
openaire   +3 more sources

Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression

Annals of Neurology, EarlyView.
Objective Magnetic resonance imaging (MRI)‐visible enlarged perivascular spaces (PVS) are markers of cerebral small vessel disease (SVD) and aging, processes implicated in both neurodegenerative and cerebrovascular pathologies. However, longitudinal positron emission tomography (PET) studies examining PVS as a mechanism underlying Alzheimer's disease ...
Audrey Low, Jeffrey L. Gunter, Mingzhao Hu, Sheelakumari Raghavan, Scott A. Przybelski, Christopher G. Schwarz, Kejal Kantarci, Val J. Lowe, Ronald C. Petersen, Jonathan Graff‐Radford, Clifford R. Jack Jr, Prashanthi Vemuri   +11 more
wiley   +1 more source

Mecanismo de centralização: da insuficiência placentária à adaptação circulatória fetal Brain sparing effect: from placental insufficiency to fetal circulatory adaptation

Revista Brasileira de Ginecologia e Obstetrícia, 2008
A aplicação e o desenvolvimento da doplervelocimetria obstétrica apresentam base para conhecimento da insuficiência placentária e comprovam o comportamento dinâmico da circulação fetal em regime de hipóxia. Na prática clínica, tornou-se quase rotineira a
Juliana Marques Simões Villas-Bôas, Izildinha Maestá, Marcos Consonni   +2 more
doaj   +1 more source