Results 41 to 50 of about 551,373 (269)

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Dynamic Autoregulation is Impaired in Circulatory Shock.

, 2020
BACKGROUND:Circulatory shock is a life-threatening disorder that is associated with high mortality, with a state of systemic and tissue hypoperfusion that can lead to organ failure, including the brain, where altered mental state is often observed.
Paulo Benigno (8146701), Letícia S Sancho (8146692), Juliana R Caldas (8146656), Giacomo Bombonato (8146698), Fabio S Taccone (7068320), Suzete Farias (8146695), João Gabriel R Ramos (8146686), André Gobatto (6468110), Angela M Salinet (8146665), Clara Ramalho (8146689), Ronney B Panerai (7298984), Rogério H Passos (8146683)   +11 more
core   +4 more sources

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Estados alterados de la conciencia tras un daño cerebral [PDF]

, 2021
Las personas somos conscientes de nosotras mismas y de nuestro entorno a través de la conciencia. No obstante, los estados alterados de la conciencia son situaciones como el coma u otros estados clínicos en los que personas con un daño cerebral severo no
Federación Española de Daño Cerebral
core  

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Studies on Cerebral Circulatory Hemodynamics Using Radioiodinated Human Serum Albumin (RISA)

RADIOISOTOPES, 1964
すでにわれわれはRISA体外計測法を用い, 頭部血量と平均脳循環時間測定値より頭部血流量を算出し, その測定法および成績について報告した。頭部血量の測定誤差は現在ほぼ7.5%以内にとどめ得るが, Loveらも指摘するごとく平均脳循環時間については方法いかんにより誤差介入の余地が大きく, 脳血流量計算値に及ぼす意義が大きい。よって, 今回かかる点を検討し頭部および頸部より同時記録した血管放射図の対比より, 頸動脈→頸静脈球循環時間 (T) , 頸動脈→脳底動脈環循環時間 (ta) , 静脈洞連合→頸静脈循環時間 (tv) を求め, これらの値より平均脳循環時間 (t) を求めた。本法によりtは正常者で平均6.7秒で再現性にすぐれ, 脳血管障害例では延長が明らかであった。
ATARASHI, Jonosuke, YOSHIMURA, Masaharu, HARA, Kazuo, TERASHI, Akiro, MIYAZAKI, Tadashi, YAMATE, Masaji, IWASAKI, Hajime, KIKUCHI, Taro, YAMANO, Takashi   +8 more
openaire   +3 more sources

Hemodynamics, cerebral circulation, and oxygen saturation in Cheyne-Stokes respiration

, 1997
Franklin, Karl A., Erik Sandström, Göran Johansson, and Eva M. Bålfors. Hemodynamics, cerebral circulation, and oxygen saturation in Cheyne-Stokes respiration. J. Appl. Physiol.
Erik Sandström, Eva M. Bålfors, Karl A. Franklin, Göran Johansson, Johansson, Göran,, Bålfors, Eva,, Franklin, Karl,, Sandström, Erik,   +7 more
core   +1 more source

Cerebral hemodynamics in children with left ventricular false tendons [PDF]

, 2020
Connective tissue dysplasia can be a predictor of heart arrhythmia and acute cerebrovascular disease in the future. At the moment, the question of the condition of cerebral hemodynamics in children with dysplasia is open.
Medrazhevskaya, Ya. A., Kuleshov, A. V., Malуk, S. L.   +2 more
core   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source