Results 61 to 70 of about 16,861 (284)

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Collateral flow and pulsatility during large vessel occlusions: insights from a quantitative in vitro study

Frontiers in Bioengineering and Biotechnology
Acute ischemic stroke caused by large vessel occlusions is being increasingly treated with neurovascular interventions. The hemodynamics within the collateral system of the circle of Willis (CoW) hemodynamics play a fundamental role in therapy success ...
Claudio A. Luisi, Omid Nikoubashman, Ulrich Steinseifer, Martin Wiesmann, Michael Neidlin   +4 more
doaj   +1 more source

Neuroprotective Properties of Xenon. [PDF]

, 2020
Xenon is a rare noble gas that was introduced into clinical practice more than 70 years ago. Xenon's clinical properties are predicated by its ability to fit into preformed cavities of macromolecules thereby altering their biological functions.
Laitio, Timo, Maze, Mervyn
core  

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Changes in cerebral blood flow and psychometric indicators in veterans with early forms of chronic brain ischemia [PDF]

Саратовский научно-медицинский журнал, 2015
The goal is to study the cerebral blood flow and psychometric characteristics in veterans of Afghanistan with early forms of chronic brain ischemia. Material and Methods. The study included 74 veterans of the Afghan war aged from 45 to 55 years: group 1,
Vasilenko Т.М., Davydova E.V.
doaj  

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Studies on Cerebral Circulatory Hemodynamics Using Radioiodinated Human Serum Albumin (RISA)

RADIOISOTOPES, 1964
すでにわれわれはRISA体外計測法を用い, 頭部血量と平均脳循環時間測定値より頭部血流量を算出し, その測定法および成績について報告した。頭部血量の測定誤差は現在ほぼ7.5%以内にとどめ得るが, Loveらも指摘するごとく平均脳循環時間については方法いかんにより誤差介入の余地が大きく, 脳血流量計算値に及ぼす意義が大きい。よって, 今回かかる点を検討し頭部および頸部より同時記録した血管放射図の対比より, 頸動脈→頸静脈球循環時間 (T) , 頸動脈→脳底動脈環循環時間 (ta) , 静脈洞連合→頸静脈循環時間 (tv) を求め, これらの値より平均脳循環時間 (t) を求めた。本法によりtは正常者で平均6.7秒で再現性にすぐれ, 脳血管障害例では延長が明らかであった。
Jonosuke ATARASHI, Masaharu YOSHIMURA, Kazuo HARA, Akiro TERASHI, Tadashi MIYAZAKI, Masaji YAMATE, Hajime IWASAKI, Taro KIKUCHI, Takashi YAMANO   +8 more
openaire   +2 more sources

Acute myocardial infarction complicated by cardiogenic shock: an algorithm based ECMO program can improve clinical outcomes. [PDF]

, 2016
Objective: Extracorporeal membrane oxygenation (ECMO) in our institution resulted in near total mortality prior to the establishment of an algorithm-based program in July 2010. We hypothesized that an algorithm based ECMO program improves the outcome of
Cavarocchi, MD, Nicholas C., Hirose, MD, Hitoshi, Ruggiero, MD, Nicholas, Tanaka, MD, Daizo, Unai, MD, Shinya   +4 more
core   +1 more source