Results 71 to 80 of about 7,738 (248)

Negative pressure breathing: the response of human respiration and circulation to different levels of rarefaction during inspiration

Frontiers in Physiology
IntroductionNegative pressure breathing is breathing with decreased pressure in the respiratory tract without lowering pressure acting on the torso. We lowered pressure only during inspiration (NPBin). NPBin is used to increase venous return to the heart
Yury S. Semenov, Julia A. Popova, Petr V. Luzhnov, Artem V. Demin, Tatiana I. Moreva, Evgeny S. Kriushev, Igor A. Nichiporuk, Alexander I. Dyachenko   +7 more
doaj   +1 more source

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, EarlyView.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Perioperative Transfusion Trigger Score Versus Restrictive Transfusion in Older Non‐Cardiac Surgery Patients: A Multicenter Randomized Controlled Trial

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Restrictive transfusion (Hb < 7 g/dL) is recommended for most perioperative patients, but the optimal threshold for those with cardiovascular disease or Hb 7–10 g/dL remains uncertain. The Perioperative Transfusion Trigger Score (POTTS), which integrates adrenaline requirement, FiO2, temperature, and angina history, may standardize ...
Shucong Liang, Lijuan Bai, Guizhen Yang, Zhuo Chen, Yujia Wei, Yanxia Wei, Yuting Lv, Zehan Huang, Yanjuan Huang, Kejian Lu   +9 more
wiley   +1 more source

PFA Under Deep Sedation and Non‐Invasive Monitoring in Atrial Fibrillation Patients With Obstructive Sleep Apnea

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background Clinical data about pulsed field ablation (PFA) under deep sedation among patients with obstructive sleep apnea (OSA) are limited, while the optimal periprocedural monitoring is not established. We report our experience in PFA among patients with atrial fibrillation (AF) and OSA, using a continuous non‐invasive respiratory and ...
Dionyssios Leftheriotis, Konstantinos A. Papathanasiou, Efstratios Karamanolis, Areti Vlachodiamanti, Evangelia Stamatopoulou, Maria Polikandrioti, Panagiota Flevari   +6 more
wiley   +1 more source

Neurovascular Disorders in Pregnancy: Prevalence, Clinical Assessment and Management—A Review of the Literature

The Obstetrician &Gynaecologist, EarlyView.
ABSTRACT Key Content Neurovascular conditions in pregnancy are rare but are associated with poor maternal and fetal outcomes. This review covers the prevalence, clinical presentation, diagnosis and management of neurovascular disorders in pregnancy. The approach to clinical assessment and investigation of pregnant women with acute or changing chronic ...
Amy Newnham, Joshua Odendaal, Toby Keown, Wen‐Xern Chong, Krunal Patel, Vandana Dhingra   +5 more
wiley   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

Effects of the angle of head‐down tilt on dynamic cerebral autoregulation during combined exposure to cephalad fluid shift and mild hypercapnia

Experimental Physiology, EarlyView.
Abstract Astronauts experience combined exposure to a cephalad fluid shift and mild hypercapnia during space missions, potentially contributing to health problems. Such combined exposure may weaken dynamic cerebral autoregulation. The magnitude of cephalad fluid shift varies between individuals, and dynamic cerebral autoregulation may be affected more ...
Tomokazu Kato, Yojiro Ogawa, Ken‐ichi Iwasaki   +2 more
wiley   +1 more source

Regional changes in cerebral blood flow between the upright and supine posture and over 3 days of bed rest

Experimental Physiology, EarlyView.
Abstract A reduction in cerebral blood flow (CBF) has been observed during spaceflight and bed rest. We aimed to examine the magnitude and regional heterogeneity of the decrease in CBF during bed rest compared to posture changes on Earth. Seventeen participants (age, 29 ± 9 years, 7 females) were studied in the upright and supine posture and over 3 ...
Carmen Possnig, Kyohei Marume, Gautam Babu, Sylvan L. J. E. Janssen, Christopher M. Hearon Jr, Katrin A. Dias, Satyam Sarma, Justin S. Lawley, Benjamin D. Levine   +8 more
wiley   +1 more source

Cerebrovascular pulsatility following long duration spaceflight is associated with changes in pulse pressure and carotid artery stiffness

Experimental Physiology, EarlyView.
Abstract Central artery stiffening increases the haemodynamic pulsations transmitted downstream towards target organs, including the brain. While recent evidence suggests that long duration spaceflight is associated with reduced common carotid artery (CCA) distensibility, cerebrovascular pulsatility has not been extensively characterized in astronauts.
Roxanne Fournier, Danielle K. Greaves, J. Kevin Shoemaker, Philippe Arbeille, Richard L. Hughson, Andrew D. Robertson   +5 more
wiley   +1 more source

Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI

Experimental Physiology, EarlyView.
Abstract Human cerebrovasculature is finely tuned to enable local changes in blood flow to meet the brain's demands, whilst protecting the brain from systemic changes in blood pressure, both acutely during a heartbeat and chronically over time. This review summarises cerebrovascular structure and function, their role in disease and neurodegeneration ...
Ian D. Driver, Kevin Murphy
wiley   +1 more source