Results 171 to 180 of about 1,638,797 (414)

Regional microstructural organization of the cerebral cortex is affected by preterm birth

open access: yesNeuroImage: Clinical, 2018
Objectives: To compare regional cerebral cortical microstructural organization between preterm infants at term-equivalent age (TEA) and healthy full-term newborns, and to examine the impact of clinical risk factors on cerebral cortical micro-organization
Marine Bouyssi-Kobar   +5 more
doaj  

Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats

open access: yesJournal of Biomedical Science, 2010
Curcumin, an active principle component in rhizome of Curcuma longa, has proved its merit for diabetes through its anti-oxidative and anti-inflammatory properties.
George Naijil   +4 more
doaj   +1 more source

Cerebral cortex inspired representation of neural field network [PDF]

open access: yesarXiv
Evolution and its intelligence element present thrill and challenges in its exploration. Yet, how species have memory, retrieve them and maintain continuity are the fundamental questions. Most of the phenomenon can only be hypothesised by researchers and validating them through experiments is a big challenge.
arxiv  

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

open access: yesAdvanced Science, EarlyView.
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro   +14 more
wiley   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

open access: yesAdvanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin   +21 more
wiley   +1 more source

Implementation of a Model of the Cortex Basal Ganglia Loop [PDF]

open access: yesarXiv
This article presents a simple model of the cortex-basal ganglia-thalamus loop, which is thought to serve for action selection and executions, and reports the results of its implementation. The model is based on the hypothesis that the cerebral cortex predicts actions, while the basal ganglia use reinforcement learning to decide whether to perform the ...
arxiv  

Modelling columnarity of pyramidal cells in the human cerebral cortex [PDF]

open access: yesarXiv, 2019
For modelling the location of pyramidal cells in the human cerebral cortex we suggest a hierarchical point process in $\mathbb{R}^3$ that exhibits anisotropy in the form of cylinders extending along the $z$-axis. The model consists first of a generalised shot noise Cox process for the $xy$-coordinates, providing cylindrical clusters, and next of a ...
arxiv  

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

open access: yesAdvanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li   +3 more
wiley   +1 more source

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