Results 161 to 170 of about 927,175 (378)

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye   +5 more
wiley   +1 more source

Etiology of Ischemic cerebral infarction in individual that are under 55 years old in Ardabil Alavis' Hospital from 2004 to 2005 [PDF]

open access: yes
Introduction: Cerebral infarction is told to acute onset of focal Neurologic symptoms that last more than 24 hour and is due to cerebro vascular accident. According to recent "WHO" reports less than 10% of patients with CVA are under 55 years old.
امینی ثانی, نیره   +2 more
core  

Pharmacological evaluation of non‐nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Traumatic brain injury (TBI) is considered to be a leading cause of mortality and disability worldwide. After TBI, innate immunity is rapidly activated in response to damage‐associated molecular patterns, such as ATP release, recognised by P2X7 receptors.
Inés Valencia   +15 more
wiley   +1 more source

Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Abstract Antenatal destructive events affecting the central nervous system of the foetus lead to disruptive brain lesions that are often associated with impaired neurodevelopment. The pathogenesis of these lesions encompasses a range of causes, including haemorrhagic, embolic, or other vascular events; exposure to teratogens, such as drugs or substance
Ana Alarcón   +33 more
wiley   +1 more source

Eustachian Valve-Enhanced Paradoxical Cerebral Embolism: A Case Report. [PDF]

open access: yesCureus, 2023
Nozue K   +4 more
europepmc   +1 more source

Patient Characteristics, Healthcare Contacts and Drug Use in Polycythaemia Vera in Denmark

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Objective Patients with polycythaemia vera (PV) may experience symptoms and cardiovascular complications before receiving a diagnosis. Understanding the associated patterns of healthcare and drug utilisation may help detect patients who need diagnostic workup.
Karoline Mathilde Lundgaard   +4 more
wiley   +1 more source

An Unusual Source of Cerebral Embolism Caused by Lambl's Excrescences. [PDF]

open access: yesCureus, 2023
Hakobyan N   +4 more
europepmc   +1 more source

Transcription‐coupled repair: tangled up in convoluted repair

open access: yesThe FEBS Journal, EarlyView.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher   +3 more
wiley   +1 more source

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