Results 71 to 80 of about 484,844 (294)

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Towards a physics informed digital twin to predict cerebral blood flow and cerebral vascular regulation

npj Digital Medicine
Cerebral blood flow is essential for brain function and is governed by cerebral perfusion pressure and physiological mechanisms collectively referred to as cerebral vascular regulation (CVR).
Jennifer K. Briggs, J. N. Stroh, Soojin Park, Brandon Foreman, Michael M. Tymko, Jay Carr, Melike Sirlanci, Philip N. Ainslie, Richard K. P. Benninger, Tellen D. Bennett, David J. Albers   +10 more
doaj   +1 more source

A Combined Computational Fluid Dynamics and Arterial Spin Labeling MRI Modeling Strategy to Quantify Patient-Specific Cerebral Hemodynamics in Cerebrovascular Occlusive Disease

Frontiers in Bioengineering and Biotechnology, 2021
Cerebral hemodynamics in the presence of cerebrovascular occlusive disease (CVOD) are influenced by the anatomy of the intracranial arteries, the degree of stenosis, the patency of collateral pathways, and the condition of the cerebral microvasculature ...
Jonas Schollenberger, Nicholas H. Osborne, Luis Hernandez-Garcia, Luis Hernandez-Garcia, C. Alberto Figueroa, C. Alberto Figueroa   +5 more
doaj   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal

Advanced Science, EarlyView.
We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao, Yi Hou, Jie Zhang, Bo Wang, Minghui Guo, Hua Qu, Wei Rao, Jing Liu   +7 more
wiley   +1 more source

Cerebral Near-Infrared Spectroscopy and Electrical Cardiometry During Endotracheal Suction in Ventilated Infants Following Surgery: A Feasibility Study

Life
Background: Near-Infrared Spectroscopy (NIRS) and Electrical Cardiometry (EC) are promising non-invasive techniques for monitoring tissue oxygenation and hemodynamics, particularly in surgically ill infants who struggle to maintain cerebral oxygenation ...
Matthias Nissen, Ralf-Bodo Tröbs
doaj   +1 more source

Doppler inspection results of first year infants with hydrocephalic syndrome of hypoxic-ischemic genesis

Бюллетень сибирской медицины, 2008
Case monitoring of 105 infants from 1 to 12 months with 1, 2 degrees cerebral ischemia was realized. Clinical, clinical-neurovisual signs of hydrocephalic syndrome were observed in 57 patients of the first group.
A. V. Kovalenko, O. V. Karkashina, K. A. Kovalkov   +2 more
doaj   +1 more source

Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus indocyanine green injection and near-infrared spectroscopy [PDF]

, 2007
To investigate the accuracy of measuring cerebral blood flow (CBF) using a bolus injection of indocyanine green (ICG) detected by near infrared spectroscopy in adult human heads, simulations were performed using a two layered model, representing the ...
Tachtsidis, I, Tachtsidis, I., Delpy, D., Tisdall, M, Leung, T., Smith, M., Elwell, CE, Elwell, C., Delpy, DT, Tisdall, M., Leung, TS, Smith, M   +11 more
core  

A model of brain circulation and metabolism: NIRS signal changes during physiological challenges [PDF]

, 2008
We construct a model of brain circulation and energy metabolism. The model is designed to explain experimental data and predict the response of the circulation and metabolism to a variety of stimuli, in particular, changes in arterial blood pressure, CO2
Mallet, Alfred, Cooper, Chris E., Clare E Elwell, Cooper, CE, Cooper, Chris E, Chris E Cooper, Nicholls, Peter Pathai, Elwell, C., Banaji, Murad, Elwell, Clare E, Nicholls, Peter, Mallet, A., Mallet, A, Elwell, CE, Banaji, M, Alfred Mallet, Murad Banaji, Peter Nicholls, Nicholls, P   +18 more
core   +2 more sources

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source